Chemical composition and antibacterial activity of Ruta graveolens L. (Rutaceae) volatile oils, from São Luís, Maranhão, Brazil

Orlanda, José Fábio França; Nascimento, Adenilde Ribeiro

doi:10.1016/j.sajb.2015.03.198

Cited by 55 publications

(35 citation statements)

References 26 publications

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“…A significant amount of undecan-2-one is present in the essential oils from the Rutaceae family [47]. Several reports on biological activities of the RGEO are available, such as on larvicidal and nematicidal activities [33], antibacterial and antifungal potential [30,31,34,36], and allelopathy activity [35], indicating that chemical composition is crucial for biological activity. However, the synergistic effect between all the essential oil components could account for the biological activity observed in several essential oils [48].…”

Section: Essential Oil Characterizationmentioning

confidence: 99%

“…Ruta graveolens (rue) essential oil has a potent antimicrobial activity due to its coumarins, flavonoids, furanocoumarins, and alkaloids content. Besides, skin pharmaceuticals preparations from rue extracts have been studied with impressive results [30][31][32][33][34][35][36][37][38]. Despite that, several authors demonstrated that the 5-and 8-methoxypsoralen were active against Rhizoctonia solanii, Fusarium spp., Pyrenochaeta lycopersici, Trichoderma viride, Penicillium spp., Thielaviopsis basicola, and Verticillium dahlia, fungi which are also present in RGEO [39][40][41].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Histological Evaluation of Chitosan-Ruta Graveolens Essential Oil Films

et al. 2020

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The development of new biocompatible materials for application in the replacement of deteriorated tissues (due to accidents and diseases) has gained a lot of attention due to the high demand around the world. Tissue engineering offers multiple options from biocompatible materials with easy resorption. Chitosan (CS) is a biopolymer derived from chitin, the second most abundant polysaccharide in nature, which has been highly used for cell regeneration applications. In this work, CS films and Ruta graveolens essential oil (RGEO) were incorporated to obtain porous and resorbable materials, which did not generate allergic reactions. An oil-free formulation (F1: CS) and three different formulations containing R. graveolens essential oil were prepared (F2: CS-RGEO 0.5%; F3: CS+RGEO 1.0%; and F4: CS+RGEO 1.5%) to evaluate the effect of the RGEO incorporation in the mechanical and thermal stability of the films. Infrared spectroscopy (FTIR) analyses demonstrated the presence of RGEO. In contrast, X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analysis showed that the crystalline structure and percentage of CS were slightly affected by the RGEO incorporation. Interesting saturation phenomena were observed for mechanical and water permeability tests when RGEO was incorporated at higher than 0.5% (v/v). The results of subdermal implantation after 30 days in Wistar rats showed that increasing the amount of RGEO resulted in greater resorption of the material, but also more significant inflammation of the tissue surrounding the materials. On the other hand, the thermal analysis showed that the RGEO incorporation almost did not affect thermal degradation. However, mechanical properties demonstrated an understandable loss of tensile strength and Young’s modulus for F3 and F4. However, given the volatility of the RGEO, it was possible to generate a slightly porous structure, as can be seen in the microstructure analysis of the surface and the cross-section of the films. The cytotoxicity analysis of the CS+RGEO compositions by the hemolysis technique agreed with in vivo results of the low toxicity observed. All these results demonstrate that films including crude essential oil have great application potential in the biomedical field.

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Section: Essential Oil Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Histological Evaluation of Chitosan-Ruta Graveolens Essential Oil Films

et al. 2020

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“…Three compounds known for their antibacterial effects of Commiphora myrrha: 2-fluorodiphenylmethane, tribenzo-1, 2,3,4,5,6anthracene and 2-bromo-1-(4-bromophenyl)ethanone [44]. Orlanda and Nascimento mention that Rutagraveolens could be used as a natural source for antibacterial compounds and possible applications in the pharmaceutical industry [45]. Several phenylethanoid glycosides isolated from Cistanche spp.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Properties of Methanolic and Aqueous Extracts of Some Plants against Some Enterobacteriaceae Species

Hamed¹,

EL-Kamali²

2016

OALib

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The extracts of six medicinal plants namely Terminalia chebula fruits, Commiphora myrrha gum, Solenostemma argel leaves, Rutagraveolens aerial parts, Cistanche phelypaea aerial parts and Striga hermonthica stem used in traditional Sudanese medicine for the treatment of gastrointestinal tract infections were selected to evaluate their potential antibacterial activity. The antibacterial activity of methanolic and aqueous extracts of these plants were determined by agar diffusion technique in vitro against 20 clinical isolates (2 were Salmonella typhi, 5 Proteus mirabilis, 4 Escherichia coli, 5 Pseudomonas aeruginosa, 3 Staphylococcus aureus, one was Salmonella paratyphi B) and 5 standard bacterial strains (Staphylococcus aureus ATCC 25923), Bacillus subtilis (NCTC 8236), Escherichia coli (ATCC 25922), Salmonella typhi (ATCC1319106) and Klebsiella pneumoniae (ATCC 35657) at a concentration of 100 mg/ml. Of all plants methanolic and aqueous extracts of T. chebula fruits were the most active with clinical isolates and standard bacterial strains showed relatively high antibacterial activity against most of the tested microorganisms with the diameter of inhibition zones ranging between 20 and 24 mm, whereas the methanolic extract of Commiphora myrrha showed high antibacterial activity against Proteus mirabilis and Escherichia coli clinical isolate (1Z = 20 mm). Solenostemma argel leaves was found moderately effective against S. aureus (ATCC 25923 ((1Z = 18 mm) but did not show any activity against all tested clinical isolates bacteria. Most susceptible Gram-negative clinical Isolates bacteria were Escherichia coli and Proteus mirabilis. Most susceptible Gram negative standard bacteria were Bacillus subtilis (NCTC 8236) and Escherichia coli (ATCC 25922) and least susceptible Gram negative bacterium was Klebsiella pneumoniae (ATCC35657). In Gram positive standard bacteria, most susceptible was S. aureus (ATCC 25923). Antibiotics was used as standards drug for antibacterial assay. The present study reveals potential use of these plants for developing new antibacterial compounds against gastrointestinal tract pathogenic microorganisms.

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“…The bioactivity of the EO of Houttuynia cordata Thunb, (medicinal plant) is caused by 2-undecanone [34]. South African R. graveolens EO had comparable ratios of nonanone and undecanone and activities against B. cereus and S. aureus [35].…”

Section: Discussionmentioning

confidence: 99%

Elevated Bioactivity of Ruta graveolens against Cancer Cells and Microbes Using Seaweeds

et al. 2020

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Human cancer and pathogenic microbes cause a significant number of deaths every year. Modulating current sources of natural products that control such diseases becomes essential. Natural algae, such as Ascophyllum nodosum and Ecklonia maxima, can modulate the metabolic processes as well the bioactivities of Ruta graveolens L. The R. graveolens plants were subjected to nine soil drenches of A. nodosum (7 mL L−1), E. maxima (7 mL L−1), or both extracts. Morphological performance, gas exchange parameters, and essential oils (EOs) composition (GC-MS) were studied and the bioactivity was assessed against several cancer cells and pathogenic bacteria or fungi. Treatment with A. nodosum + E. maxima seaweed extracts (SWE) led to the highest morphological performance and gas exchange parameters. The highest antiproliferative, apoptotic, and caspase-3/7 activities of EO were against HeLa in SWE mixture treated plants. The best EO antimicrobial activities were obtained against Staphylococcus aureus and Penicillium ochrochloron. SWE mixtures treated plants showed the best bioactivities against microbes and cancer cells. The highest abundance of 2-undecanone (62%) and 2-nonanone (18%) was found in plants treated with SWE mixtures and caused the best anticancer and antimicrobial effects. Seaweed mixtures act as natural elicitors of pharmaceutical industries and favored 2-undecanone and 2-nonanone in R. graveolens.

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Chemical composition and antibacterial activity of Ruta graveolens L. (Rutaceae) volatile oils, from São Luís, Maranhão, Brazil

Cited by 55 publications

References 26 publications

Synthesis, Characterization, and Histological Evaluation of Chitosan-Ruta Graveolens Essential Oil Films

Synthesis, Characterization, and Histological Evaluation of Chitosan-Ruta Graveolens Essential Oil Films

Antibacterial Properties of Methanolic and Aqueous Extracts of Some Plants against Some Enterobacteriaceae Species

Elevated Bioactivity of Ruta graveolens against Cancer Cells and Microbes Using Seaweeds

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