Chemical composition and antimicrobial activity of leave extract of Ocimum lamiifolium (Damakese) as a treatment for urinary tract infection

Sahalie, Nigus Aweke; Tolesa, Leta Deressa

doi:10.1080/23312009.2018.1440894

Cited by 21 publications

(17 citation statements)

References 15 publications

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“…Dama Kesse is a versatile aromatic genus that is particularly popular in Ethiopia, with anti-malarial, antipyretic, anti-oxidant, anti-spasmodic, and anti-bacterial properties (Kefe et al, 2016;Ahmed et al, 2018b;Sahalie et al, 2018). Despite its widespread use among pregnant women across Ethiopia (Adane et al, 2020), Dama Kesse is very poorly studied, with no clinical studies identified.…”

Section: Most Commonly Used Herbal Medicines During Pregnancy In Sub-saharan Africamentioning

confidence: 99%

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

Hajj

Holst

2020

Front. Pharmacol.

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Herbal medicine use has grown considerably worldwide among pregnant women, and is particularly widespread in sub-Saharan Africa. However, herbal medicines used across sub-Saharan Africa are associated with important research gaps and a lack of regulatory framework. This is particularly problematic, as herbal medicine use during pregnancy raises several concerns attributed to the herbal ingredient itself, conventional drug-herbal medicine interactions, and contamination or adulteration of herbal remedies. Moreover, several local herbal remedies used by sub-Saharan African pregnant women have never been botanically identified. In this review, an overview of the practice of herbal medicine, including the regulations, challenges and overall safety, is provided. Then, we discuss the prevalence of herbal medicine use during pregnancy across different sub-Saharan African countries, as well as the indications, adverse outcomes, and effectiveness of the most commonly used herbal medicines during pregnancy in that region.

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Section: Most Commonly Used Herbal Medicines During Pregnancy In Sub-saharan Africamentioning

confidence: 99%

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

Hajj

Holst

2020

Front. Pharmacol.

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“…All these plants are used for the preparation of traditional medicines and few of them for culinary purposes. A perusal of the literature indicated that the antimicrobial activities of these medicinal plants against bacteria have been extensively investigated by a number of researchers (Geyid et al, 2005;Naz et al, 2015;Lulekal et al, 2014;Mekonnen et al, 2016;Meressa, 2017;Sahalie et al, 2018). Nevertheless, studies on the effect of Ethiopian medicinal plants against biofilm-forming MRSA sourced from human immunodeficiency virus (HIV) infected patients are not done so far.…”

Section: Introductionmentioning

confidence: 99%

In vitro antibacterial activity of medicinal plants against biofilm-forming methicillin-resistant Staphylococcus aureus: efficacy of Moringa stenopetala and Rosmarinus officinalis extracts

Manilal

Sabu

Shewangizaw

et al. 2020

Heliyon

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The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) is slowly rising in Ethiopia for the past few decades. Therefore, novel classes of antibiotics are indispensable to combat the increased incidence of newly emerging multidrug-resistant bacteria like MRSA. Terrestrial flora is considered as a reservoir of novel bioactive secondary metabolites as they have provided us with the largest array of natural products. In this background, the present study is intended to evaluate the in-vitro antibacterial efficacy of five medicinal plants (Ocimum lamiifolium Hochst. ex Benth., Rosmarinus officinalis L, Catharanthus roseus Linn., Azadirachta indica A. Juss and Moringa stenopetala Bac) against a panel of seven biofilm-forming MRSA. The leaves of the plants were extracted in organic solvents of varying polarity and the resultant crude extracts of respective medicinal plants were inspected for their antimicrobial activity by well diffusion technique. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of the plant extracts against MRSA were determined by the broth dilution method. Besides, an anti-biofilm assay of the most potent plant extract was also performed, after which its chemical constituents were delineated by combined Gas Chromatographic and Mass Spectroscopic profiling (GC-MS). The results revealed that, of the five plants, three species including M. stenopetala, R. officinalis, and O. lamifolium exhibited significant antibacterial activity. Organic solvents with high and medium polarity were excellent in extracting antimicrobials compared to nonpolar solvents. The broadest and highest rank of activity was observed in the crude ethanolic extract of M. stenopetala. Based on the MIC/MBC ratio, the crude ethanolic extract of M. stenopetala was determined to be bacteriostatic. Anti-biofilm assay showed that the extract of M. stenopetala fairly inhibited the growth of MRSA in the preformed biofilm matrix. The GC-MS analysis of M. stenopetala revealed the presence of twelve compounds with antimicrobial activity. The present study provides new insight into the development of novel drug leads to the management of MRSA.

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“…The qualitative phytochemical investigation of the aqueous root extract of E racemosa was performed using standard tests with a slight modification [ [14] , [15] , [16] ].…”

Section: Methodsmentioning

confidence: 99%

Evaluations of the in vivo laxative effects of aqueous root extracts of Euclea racemosa L. in mice

2023

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Chemical composition and antimicrobial activity of leave extract of Ocimum lamiifolium (Damakese) as a treatment for urinary tract infection

Cited by 21 publications

References 15 publications

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

Herbal Medicine Use During Pregnancy: A Review of the Literature With a Special Focus on Sub-Saharan Africa

In vitro antibacterial activity of medicinal plants against biofilm-forming methicillin-resistant Staphylococcus aureus: efficacy of Moringa stenopetala and Rosmarinus officinalis extracts

Evaluations of the in vivo laxative effects of aqueous root extracts of Euclea racemosa L. in mice

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