Chemical Composition of Five Commercial Gynostemma pentaphyllum Samples and Their Radical Scavenging, Antiproliferative, and Anti-inflammatory Properties

Xie, Zhuohong; Liu, Wei; Huang, Haiqiu; Slavin, Margaret; Zhao, Yang; Whent, Monica; Blackford, Jessica; Lutterodt, Herman; Zhou, Huiping; Chen, Pei; Wang, Thomas T.Y.; Wang, Shaoke; Yu, Liangli

doi:10.1021/jf1026372

Cited by 72 publications

(50 citation statements)

References 32 publications

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“…At present, it is not known if the polyploid complex of G. pentaphyllum is autopolyploid or allopolyploid, and the genetic signature and origin of populations with different ploidies are still unclear. As a traditional Chinese medicinal herb, G. pentaphyllum is useful in medical science because it can inhibit the reproduction of tumor cells, regulate lipid metabolism, decrease blood sugar, and enhance immunity (Xie et al, 2010). Thus, most studies of this species have focused on the extraction (Yin, Hu, & Pan, 2004), chemistry, and pharmacology (Razmovski-Naumovski et al, 2005;Tsai, Lin, & Chen, 2010) of its bioactive components.…”

Section: Introductionmentioning

confidence: 99%

Population genetic structure, migration, and polyploidy origin of a medicinal species Gynostemma pentaphyllum (Cucurbitaceae)

Zhang

Yang

et al. 2019

Ecology and Evolution

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Gynostemma pentaphyllum, a member of family Cucurbitaceae, is a perennial creeping herb used as a traditional medicinal plant in China. In this study, six polymorphic nSSR and four EST‐SSR primers were used to genotype 1,020 individuals in 72 wild populations of G. pentaphyllum. The genetic diversity and population structure were investigated, and ecological niche modeling was performed to reveal the evolution and demographic history of its natural populations. The results show that G. pentaphyllum has a low level of genetic diversity and high level of variation among populations because of pervasive asexual propagation, genetic drift, and long‐term habitat isolation. Results of the Mantel test demonstrate that the genetic distance and geographic distance are significantly correlated among G. pentaphyllum natural populations. The populations can be divided into two clusters on the basis of genetic structure. Asymmetrical patterns of historical gene flow were observed among the clusters. For the contemporary, almost all the bidirectional gene flow of the related pairs was symmetrical with slight differences. Recent bottlenecks were experienced by 34.72% of the studied populations. The geographic range of G. pentaphyllum continues to expand northward and eastward from Hengduan Mountains. The present distribution of G. pentaphyllum is a consequence of its complex evolution. Polyploidy in G. pentaphyllum is inferred to be polygenetic. Finally, G. pentaphyllum is a species in need of protection, so in situ and ex situ measures should be considered in the future.

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Section: Introductionmentioning

confidence: 99%

Population genetic structure, migration, and polyploidy origin of a medicinal species Gynostemma pentaphyllum (Cucurbitaceae)

Zhang

Yang

et al. 2019

Ecology and Evolution

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“…20 The results were reported as mg rutin equivalents (RNE) per gram of extract. 20 The results were reported as mg rutin equivalents (RNE) per gram of extract.…”

Section: Determination Of the Total Flavonoid Content (Tfc)mentioning

confidence: 99%

Nutrient values and bioactivities of the extracts from three fern species in China: a comparative assessment

Yang

Xiao

et al. 2015

Food Funct.

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Pteridium aquilinum, Osmunda cinnamomea Linn, and Athyrium multidentatum (Doll.) Ching are three fern species widely consumed as potherbs and traditional medicinal herbs in China. Nevertheless, no detailed comparative assessments of their nutrient values and bioactivities have been reported. In this paper, we examined the nutrient content of these ferns and the bioactivities of their extracts with a comparative method. The results indicated that they were nutrient dense for proteins, carbohydrates, fat and minerals. Compared with Pteridium aquilinum and Osmunda cinnamomea Linn, the extract from Athyrium multidentatum (Doll.) Ching was found to possess the strongest antioxidant activity, protective effects on biomolecules, cellular antioxidant activity, and antiproliferative effects owing to its highest total phenolic (476.52 ± 11.26 mg GAE per g extract) and total flavonoid (924.81 ± 4.25 mg RNE per g extract) contents. Further, Athyrium multidentatum (Doll.) Ching can lead to caspase-3 activation, poly ADP-ribose polymerase cleavage, mitochondrial membrane potential (MMP) reduction and inhibition of wound-healing in a dose-dependent manner in HepG2 cells. These results demonstrate the remarkable potential of Pteridium aquilinum, Osmunda cinnamomea Linn, and Athyrium multidentatum (Doll.) Ching as valuable sources of nutrients and natural antioxidants, and among which Athyrium multidentatum (Doll.) Ching has potential anticancer properties.

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“…Gynostemma pentaphyllum Makino, known as Jiaogulan , is a perennial liana plant and has been traditionally used in food, tea, and folk medicines in many east and southeast Asian countries due to its possible health properties, such as lowering cholesterol and high blood pressure, hypoglycemic, anti-inflammatory, and anticancer activities. [ 8 9 10 ]…”

Section: Introductionmentioning

confidence: 99%

Preparation and bioactivity of exopolysaccharide from an endophytic fungus Chaetomium sp. of the medicinal plant gynostemma pentaphylla

Zhang¹,

Wang²,

Li³

et al. 2017

Phcog Mag

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Background:Many exopolysaccharides from the endophytes in medicinal plants possess various potential bioactivities.Materials and Methods:The endophytic fungus JY25 was isolated from the leave of the Chinese medicinal plant Gynostemma pentaphylla and identified as Chaetomium sp. by its phylogenetic and physiological analysis. One exopolysaccharide (EPS) fraction was isolated from the fermentation broth by ethanol precipitation and purified by gel filtration chromatography on Sepharose CL-6B. The molecular characteristics were examined by GC-MS, FT-IR, and multiangle laser light scattering (MALLS).Results:The monosaccharide composition analysis indicated that the purified EPS was mainly composed of glucose, mannose, arabinose, and galactose with the molecular ratio of 78.29: 8.99: 8.64: 4.08. FT-IR spectral analysis of the purified EPS revealed prominent characteristic groups, such as carbonyl bond, pyranose ring, and so on. The weight-average molar mass and the polydispersity ratio of the EPS were revealed to be 1.961×104 g/mol and 1.838, respectively. Furthermore, thermo gravimetric analysis (TGA) indicated that the degradation temperature of the purified EPS was 305° C. The purified EPS from the endophytic fungus Chaetomium sp. displayed antioxidant and antiproliferative activities.Conclusion:The results demonstrated that the EPS could be used as a healthful food and material source in pharmaceutical industries.SUMMARY An exopolysaccharides (EPS) with antioxidant and antiproliferative activities from an endophytic fungus Chaetomium sp. was reported. Abbreviations used: ANOVA: Analysis of variance; DPPH: 2,2-diphenyl-1-picrylhydrazyl; EPS: Exopolysaccharide; FT-IR: Fourier transform infrared spectroscopy; GC-MS: Gas chromatography–mass spectrometry; Mw: Mass weight; MALLS: Multiangle laser light scattering; SEC: Size Exclusion Chomatography; SPSS: Statistical Package of the Social Science; TGA: Thermo gravimetric analysis; TFA: Trifluoroacetic acid.

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Chemical Composition of Five Commercial Gynostemma pentaphyllum Samples and Their Radical Scavenging, Antiproliferative, and Anti-inflammatory Properties

Cited by 72 publications

References 32 publications

Population genetic structure, migration, and polyploidy origin of a medicinal species Gynostemma pentaphyllum (Cucurbitaceae)

Population genetic structure, migration, and polyploidy origin of a medicinal species Gynostemma pentaphyllum (Cucurbitaceae)

Nutrient values and bioactivities of the extracts from three fern species in China: a comparative assessment

Preparation and bioactivity of exopolysaccharide from an endophytic fungus Chaetomium sp. of the medicinal plant gynostemma pentaphylla

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