Chemical compositions of <i>Commiphora opobalsamum</i> stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage

Farid, Mai M.; Naser, Asmaa F Aboul; Salem, Maha; Ahmed, Yomna R.; Emam, Mahmoud; Hamed, Manal A.

doi:10.1080/1354750x.2022.2099015

Cited by 10 publications

(7 citation statements)

References 75 publications

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“…DM is commonly associated with dyslipidemia that can lead to an increased predisposition toward development of non-alcoholic fatty liver disease and risk of heart diseases [ 42 , 43 ]. Dyslipidemia is characterized by elevated levels of bad fats, i.e., cholesterol, HDL, and TG, concurrent with a decrease in HDL level.…”

Section: Resultsmentioning

confidence: 99%

Comparative Insights into Four Major Legume Sprouts Efficacies for Diabetes Management and Its Complications: Untargeted versus Targeted NMR Biochemometrics Approach

et al. 2022

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Interest in the consumption of seed sprouts is gradually increasing as functional foods in the modern Western diet owing to their several nutritional and health benefits. The present study aims to investigate four major legume sprouts derived from faba bean (Vicia faba L.), lentil (Lens esculenta L.), chickpea (Cicer arietinum L.), and fenugreek (Trigonella foenum-greacum L.) for their antidiabetic activity and mitigation of associated complications, i.e., oxidative stress, liver dysfunction, and lipid metabolism, compared with glibenclamide. Biochemical results presented herein further showed that the four sprouts exhibited significant hypoglycemic effects (p < 0.05), with improvement in decreasing of blood glucose levels at different degrees and with faba bean sprout most active at 348% improvement, compared to 364.3% for glibenclamide. Further biochemometric analysis based on a comparison between targeted versus untargeted partial least square (PLS) and regression analyses revealed that faba bean sprouts’ richness in flavonoids was a determinant key factor for such efficacy. In addition, correlation with previously investigated NMR fingerprinting aided in pinpointing other active agents, such as betaine and L-DOPA. Furthermore, the effect on serum liver enzymes, including alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase; oxidative stress markers; and lipid profiles showed significant improvement, especially in the case of faba bean sprout. The study revealed the potential health benefits of legume sprouts in the treatment of diabetes and its associated complications, as well as the potential role of biochemometrics in active agents’ identification in such a complex matrix to be considered for other functional foods investigation.

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Section: Resultsmentioning

confidence: 99%

Comparative Insights into Four Major Legume Sprouts Efficacies for Diabetes Management and Its Complications: Untargeted versus Targeted NMR Biochemometrics Approach

et al. 2022

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“…[4,6,7,73,74] Flavonoid and its derivatives are the most prevalent form of polyphenol and the best scavengers of peroxyl radicals, making them a potent lipid peroxidation inhibitor. [7,74,75] Quercetin improves the histological characteristics of inflammation by inhibiting leucocyte recruitment, lowering chemokine levels, and slowing down the oxidation of lipids. [76] Additionally, [76] reported that isorhamnetin glycosides, when compared to indomethacin, modify the inflammatory response by lowering the level of IL-6 and TNF-α in rats with ear edema.…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoid and its derivatives are the most prevalent form of polyphenol and the best scavengers of peroxyl radicals, making them a potent lipid peroxidation inhibitor [7,74,75] . Quercetin improves the histological characteristics of inflammation by inhibiting leucocyte recruitment, lowering chemokine levels, and slowing down the oxidation of lipids [76] .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory mediators, oxidative stress and genetic disturbance in rheumatoid arthritis rats supported by alfalfa seeds metabolomic constituents via blocking interleukin‐1receptor.

Aboul Naser,

Ahmed,

Mohammed

et al. 2024

Chemistry & Biodiversity

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by aggressive cartilage and bone erosion. This work aimed to evaluate the metabolomic profile of Medicago sativa L. (MS) seeds and explore its therapeutic impact against RA in rats. Arthritis was induced by complete Freund’s adjuvant (CFA) and its severity was assessed by the arthritis index. Treatment with MS seeds butanol fraction and interlukin‐1 receptor antagonist (IL‐1RA) were evaluated through measuring interlukin‐1 receptor (IL‐1R) type 1 gene expression, interlukin‐1 beta (IL‐1β), oxidative stress markers, C‐reactive protein (CRP), tumor necrosis factor‐alpha (TNF‐α), prostaglandin E2 (PGE2), caspase‐3 (Cas‐3), intracellular adhesion molecule‐1 (ICAM‐1), DNA fragmentation, and chromosomal damage. Total phenolics/ flavonoids content in the ethyl acetate, butanol fraction and crude extract of MS seeds were estimated. The major identified compounds were Quercetin, Trans‐taxifolin, gallic acid, 7,4'‐Dihydroxyflavone, Cinnamic acid, Kudzusaponin SA4, Isorhamnetin 3‐O‐beta‐D‐2'',3'',4''‐triacetylglucopyranoside, Apigenin, 5,7,4'‐Trihydroxy‐3'‐methoxyflavone, Desmethylxanthohumol, Pantothenic acid, Soyasapogenol E, Malvidin, Helilandin B, Stigmasterol, and Wairol. Treatment with MS seeds butanol fraction and IL‐1RA enhanced all the biochemical parameters and the histopathological features of the ankle joint. In conclusion, Trans‐taxifolin was isolated for the first time from the genus Medicago. MS butanol fraction seeds extract and IL‐1 RA were considered as anti‐rheumatic agents.

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“…[13] Free radical production and removal from the body are balanced under normal circumstances, [14] while under illness condition; the antioxidant capacity is inadequate to eliminate these free radicals. [15,16] ACR toxicity resulted from the imbalance between the generations of reactive oxygen species (ROS) and the antioxidant capability that lead to increase oxidative stress condition. [17] Hence, any pathogenic processes including infertility are associated with excessive levels of oxidative stress, a significant reduction in glutathione, and catalase as well as a significant increment in MDA formation.…”

Section: Introductionmentioning

confidence: 99%

Mitigating Effect of Lepidium sativum Seeds Oil on Ovarian Oxidative Stress, DNA Abnormality and Hormonal Disturbances Induced by Acrylamide in Rats

Aboul Naser,

El‐Feky,

Hamed

2024

Chemistry & Biodiversity

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Acrylamide (ACR), an industrial compound, causes both male and female reproductive toxicity. Lepidium sativum seeds (L. sativum) (Garden cress) are known for their health benefits as antioxidant, antiasthmatic, anticoagulant, anti‐inflammatory, and analgesic agents. Therefore, this study aimed to investigate the phytochemistry and nutritional value of L. sativum seeds oil for attenuating the ovarian damage induced by acrylamide in rats. The phytochemical investigation of the seeds revealed the presence of vitamins, potassium, iron, sugar and amino acids. Twenty eight compounds from the unsaponifiable fraction and twenty three compounds from the saponifiable fraction were identified. Three sterols and two triterpenes were isolated and identified as β‐sitosterol (1), ∆5‐avenasterol (2), friedelanol (3), stigmasta‐4, 22‐dien‐3‐one (4), and ursolic acid (5). Treatment of acrylamide‐induced rats with L. sativum seeds oil ameliorated prolactin (PRL), progesterone (P4), estradiol (E2), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), nitric oxide (NO), interleukin‐6 (IL‐6), and tumor necrosis factor alpha (TNF‐ α) with variable degrees. The histopathological findings of ovaries supported these results. In conclusion, compounds (3‐5) were isolated for the first time from L. sativum seeds oil. The seeds oil attenuated the ovarian damage and could potentially be a new supplemental agent against female infertility.

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Chemical compositions of Commiphora opobalsamum stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage

Cited by 10 publications

References 75 publications

Comparative Insights into Four Major Legume Sprouts Efficacies for Diabetes Management and Its Complications: Untargeted versus Targeted NMR Biochemometrics Approach

Comparative Insights into Four Major Legume Sprouts Efficacies for Diabetes Management and Its Complications: Untargeted versus Targeted NMR Biochemometrics Approach

Inflammatory mediators, oxidative stress and genetic disturbance in rheumatoid arthritis rats supported by alfalfa seeds metabolomic constituents via blocking interleukin‐1receptor.

Mitigating Effect of Lepidium sativum Seeds Oil on Ovarian Oxidative Stress, DNA Abnormality and Hormonal Disturbances Induced by Acrylamide in Rats

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