Chemical constituents and chemotaxonomic study on the marine actinomycete Williamsia sp. MCCC 1A11233

Xie, Conghua; Niu, Siwen; Zhou, Tingting; Zhang, Gaiyun; Yang, Quan; Yang, Xiong‐Li

doi:10.1016/j.bse.2016.06.004

Cited by 5 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Effects of CDMW on Degranulation and Histamine Release in IgE-Sensitized RBL-2H3 cells. CDMW are obtained as described by Chunlan Xie, 23 numbered as CDMW-1∼CDMW-24. To determine the antiallergic activities of the CDMW, we examined their potential bioactivities in suppressing degranulation and histamine release in IgE-sensitized mast cells.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Strain MCCC 1A11233 was isolated from a sediment sample (depth 1654 m; E 49.81, S 37.86) from the southwestern Indian Ocean in February 2014. There are 24 kinds of compounds were obtained and numbered CDMW-1∼CDMW-24 as described by Xie et al 23 RBL-2H3 Assay. RBL-2H3 cells were obtained from the American Type Culture Collection (ATCC, Manassas, VA, U.S.A.).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…MCCC 1A11233 (CDMW). 23 However, the activities of these CDMW have not been explored. In this study, we assessed the antiallergic properties of these CDMW by investigating their effects on IgE-stimulated mast cells in vitro and mast cell-dependent passive cutaneous anaphylaxis (PCA) in vivo.…”

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibitory Activities of Compounds from the Marine Actinomycete Williamsia sp. MCCC 1A11233 Variant on IgE-Mediated Mast Cells and Passive Cutaneous Anaphylaxis

Gao

Liu

et al. 2017

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

The compounds of the deep-sea-derived marine Williamsia sp. MCCC 1A11233 (CDMW) were isolated, which are secondary metabolites of the actinomycetes. In this study, seven kinds of CDMW were found to decrease degranulation and histamine release in immunoglobulin E (IgE)-mediated rat basophilic leukemia (RBL)-2H3 cells. The production of cytokines (tumor necrosis factor-α, interleukin-4) was inhibited by these CDMW in RBL-2H3 cells, and their chemical structures were established mainly based on detailed analysis of their NMR spectra. CDMW-3, CDMW-5, and CDMW-15 were further demonstrated to block mast cell-dependent passive cutaneous anaphylaxis in IgE-sensitized mice. Bone marrow mononuclear cells (BMMCs) were established to clarify the effect of CDMW-3, CDMW-5, and CDMW-15 on mast cells. The seven kinds of CDMW decreased the degranulation and histamine release of BMMCs. Furthermore, flow cytometry results indicated that CDMW-3, CDMW-5, and CDMW-15 increased the annexin cell population of BMMCs. In conclusion, CDMW-3, CDMW-5, and CDMW-15 have obvious antiallergic activity due to induction of the apoptosis of mast cells.

show abstract

Section: ■ Resultsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Inhibitory Activities of Compounds from the Marine Actinomycete Williamsia sp. MCCC 1A11233 Variant on IgE-Mediated Mast Cells and Passive Cutaneous Anaphylaxis

Gao

Liu

et al. 2017

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…A threo isomer of 4 was previously isolated from a actinomycete Williamsia sp. MCCC 1A11233 (Figures S24-S28) [38]. The configuration of 4 was assigned upon careful comparison of the NMR data with those reported for the four synthetic stereoisomers, two threo (2S,3R and 2R,3S) and two erythro (2S,2S and 2R,3R) [26,37] (Table S5).…”

Section: Structure Elucidationmentioning

confidence: 99%

“…Based on the reported biogenesis of indole alkaloids from bacteria [11,13,[35][36][37][38], we proposed the biosynthesis pathways of compounds 1-4 (Figure 2). Inspection of the structure of legonimide 1 led us to speculate that it is biosynthesized from the condensation reaction between the phenyl-acetyl-CoA, a common intermediate, and the indole-3-acetamide 12, an oxidative product of l-tryptophan 6 catalysed by tryptophan 2-monooxygenase [39].…”

Section: Proposed Biosynthesis Pathway Of 1-4mentioning

confidence: 99%

Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37

et al. 2020

View full text Add to dashboard Cite

Four compounds (1–4) were isolated from the extracts of Streptomyces sp. CT37 using bioassay in conjunction with mass spectrometric molecular networking (MN) driven isolation. Their complete structures were established by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), and 1D and 2D nuclear magnetic resonance (NMR) data. Legonimide 1 was identified as a new alkaloid containing a rare linear imide motif in its structure, while compounds 2–4 were already known and their structures were elucidated as 1H-indole-3-carbaldehyde, actinopolymorphol B, (2R,3R)-1-phenylbutane-2,3-diol, respectively. The biosynthetic pathways of 1–4 were proposed based on the reported biogenesis of indole alkaloids in literature. Bioactivity tests for 1 and 2 revealed moderate growth inhibition activity against Candida albicans ATCC 10231 with MIC95 values of 21.54 µg/mL and 11.47 µg/mL, respectively.

show abstract

Marine natural products

et al. 2018

View full text Add to dashboard Cite

Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.

show abstract

Chemical constituents and chemotaxonomic study on the marine actinomycete Williamsia sp. MCCC 1A11233

Cited by 5 publications

References 33 publications

Inhibitory Activities of Compounds from the Marine Actinomycete Williamsia sp. MCCC 1A11233 Variant on IgE-Mediated Mast Cells and Passive Cutaneous Anaphylaxis

Inhibitory Activities of Compounds from the Marine Actinomycete Williamsia sp. MCCC 1A11233 Variant on IgE-Mediated Mast Cells and Passive Cutaneous Anaphylaxis

Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37

Marine natural products

Contact Info

Product

Resources

About