Chemical Constituents and Pharmacological Effects of Genus Patrinia: a Review

Meng, Lijun; Chen, Sitan; Zhou, Li; Liu, Zhenhua; Li, Shiming

doi:10.1007/s40495-020-00240-7

Cited by 12 publications

(7 citation statements)

References 103 publications

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“…Pharmacology researches showed that PS possessed good antibacterial activity in vitro. 10 The studies demonstrated that the extracts of PS had significant antibacterial activity against S. aureus, Staphylococcus albus, typhoid bacillus,Streptococcus B, pneumococcus,Escherichia coli, dysentery bacillus, and Pseudomonas aeruginosa. 10,11 However, the antibacterial mechanism of PS against MRSE is still unknown.…”

Section: Introductionmentioning

confidence: 98%

Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Liu¹,

An²,

Zhou³

et al. 2023

IDR

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Staphylococcus epidermidis has become one of the most common causes of septicemia. Meanwhile, S. epidermidis has acquired resistance to many antibiotics. Among these, methicillin-resistant S. epidermidis (MRSE) were frequently isolated. Similar to methicillin resistant Staphylococcus aureus (MRSA), they also exhibited multi-resistance, which presented a danger to human health. Patrinia scabiosaefolia as traditional Chinese medicine had strong antibacterial activity against MRSE. However, the mechanism of P. scabiosaefolia against MRSE is not clear. Methods: Here, the morphology of cell wall and cell membrane, production of β-lactamase and PBP2, energy metabolism, antioxidant system were systematically studied. Results: The data showed that P. scabiosaefolia damaged the cell wall and membrane. In addition, β-lactamase, energy metabolism and antioxidant system were involved in mechanisms of P. scabiosaefolia against MRSE. Conclusion: These observations provided new understanding of P. scabiosaefolia against MRSE to control MRSE infections.

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Section: Introductionmentioning

confidence: 98%

Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Liu¹,

An²,

Zhou³

et al. 2023

IDR

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“…It was the first record in “ Shen Nong's Herbal Classic ”, used to treat appendicitis, enteritis, hepatitis, etc. Since P. scabiosaefolia has strong putrid odor, it is named as “Baijiang Cao” in Chinese name, whose main chemical constituents is iridoids [ 16 ]. In our previous studies, two iridoids patrinoside and patrinoside A ( Figure 1 ) isolated from Patrinia scabiosaefolia , which could improve insulin resistance (IR) of adipocytes by activating PI3K/AKT signaling pathway [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Patrinoside and Patrinoside A from Patrinia scabiosaefolia Improve Insulin Resistance by Inhibiting NF-κB, MAPK Pathways and Oxidative Stress in RAW264.7 and 3 T3-L1 Cells

Liu

Wang

Liu

et al. 2023

Oxidative Medicine and Cellular Longevity

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Patrinia scabiosaefolia, as traditional food and medicine plant, was used to treat appendicitis, enteritis, and hepatitis for thousand years in China. Patrinoside and patrinoside A isolated from P. scabiosaefolia could significantly improve insulin resistance (IR) by activating PI-3 K/AKT signaling pathway in our previous study. Since IR is closely related to inflammation, their anti-inflammatory activities in RAW264.7 inflammatory model induced by LPS and in 3 T3-L1 IR inflammatory model induced by TNF-α were evaluated to identify whether the effects on improving IR related to anti-inflammatory activity. In RAW264.7 cells, patrinoside and patrinoside A significantly inhibited the transcription and secretion of inflammatory mediators NO, TNF-α, and IL-6. Western blot analysis showed that the significant inhibition of phosphorylation of IκB and P65 and P38, ERK and JNK suggested that the effects were exerted through NF-κB pathway and MAPK pathway. In 3 T3-L1 cells, patrinoside and patrinoside A also inhibited the activation of NF-κB and MAPK pathways through inhibiting the transcriptions of inflammatory cytokines IL-6 and chemokines MCP-1 and MIP-1α. These events resulted in the inhibition of macrophages migration to adipocytes. In addition, patrinoside and patrinoside A ameliorated oxidative stress by inhibiting ROS release in LPS-stimulated RAW264.7 cells. In conclusion, patrinoside and patrinoside A could active PI-3 K/AKT pathway, inhibit NF-κB pathway, MAPK pathway, and improve oxidative stress, which showed multipathways on improving IR. These results provided the scientific basis for material basis and mechanism on improving IR of P. scabiosaefolia.

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“…Patrinia scabra Bunge (family: Valerianaceae) is a perennial herb that has been used in traditional oriental medicine for the treatment of various inflammatory diseases, such as fever, malaria, dysentery, leukemia, and ulcers. 12 Phytochemical studies on P. scabra have indicated that its pharmacological effects are derived from its characteristic metabolites, such as iridoids, sesquiterpenes, triterpenes, lignans, and other phenolic compounds. 12 Notably, the volatile oil derived from P. scabra roots has shown significant cytotoxicity against human ovarian carcinoma and human hepatoma cells.…”

Section: Introductionmentioning

confidence: 99%

Patriniaterpenes A–D: unveiling the unique structure and antioxidant properties of monoterpene–sesquiterpene conjugates from Patrinia scabra

et al. 2023

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Chemical Constituents and Pharmacological Effects of Genus Patrinia: a Review

Cited by 12 publications

References 103 publications

Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Patrinoside and Patrinoside A from Patrinia scabiosaefolia Improve Insulin Resistance by Inhibiting NF-κB, MAPK Pathways and Oxidative Stress in RAW264.7 and 3 T3-L1 Cells

Patriniaterpenes A–D: unveiling the unique structure and antioxidant properties of monoterpene–sesquiterpene conjugates from Patrinia scabra

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