Chemical Constituents, Antioxidant, Anticholinesterase and Antiproliferative Effects of Algerian Pistacia atlantica Desf. Extracts

Achili, Imene; Amrani, Amel; Bensouici, Chawki; Gül, Fatih; Altun, Muhammed; Demirtaş, İbrahim; Zama, Djamila; Benayache, Fadila

doi:10.2174/2212798411666200207101502

Cited by 17 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although it is generally thought that the flavonoids and phenols contained in the leaves are responsible for the antioxidant activity of the plant, studies have been carried out to determine the compounds responsible for the effect with further instrumental analysis techniques (HPLC and LC-MS) (Benhammou et al, 2008). As a result of these analyzes, the presence of phenolic compounds such as gallic acid, digallic, cichoric, quinic, gentisic, vanillic, protocatechuic, rosmarinic, galloylquinic, digalloylquinic, trigalloylquinic, tetragalloylquinic, galloylshikimic acids, trigalloylglucose, tetragalloylglucose, rutin catechin, quercetin, methyl gallate, and glucogallin in the leaves of the plant was determined (Benhammou et al, 2008;Ahmed et al, 2016;Toul et al, 2017;Benamar et al, 2018;Achili et al, 2020). On the other hand, Peksel et al (2010) evaluated the antioxidant potential of methanol and ethyl acetate extracts of P. atlantica leaves collected from Istanbul.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Pekacar

Orhan

2022

Front. Pharmacol.

View full text Add to dashboard Cite

In this study, the antidiabetic, antiobesity, antioxidant, and antihyperlipidemic effects potential of Pistacia atlantica Desf. leaves were evaluated by in vitro methods. The effects of the leaves of the plant on pancreatic lipase, pancreatic cholesterol esterase, and PTP1B enzymes were investigated for the first time and it was observed that leaf methanol extract (IC50: 123.67 ± 0.40 μg/ml) and n-hexane sub-extract (IC50: 61.03 ± 0.11 μg/ml) had much stronger effects on pancreatic cholesterol esterase enzyme than simvastatin (IC50: 142.30 ± 5.67 μg/ml). The methanolic extract of P. atlantica leaves exerted strong inhibitory effect on the enzymes (α-amylase and α-glucosidase) effective on carbohydrate digestion. It was thought that the methanol extract could provide significant benefits against oxidative stress in diabetes mellitus since it showed antioxidant activities (DPPH radical scavenging activity and reducing power) as strong as reference compounds (ascorbic acid and quercetin). Qualitative and quantitative analyzes of rutin (0.328 ± 0.000 g/100 g dry extract), methyl gallate (5.245 ± 0.014 g/100 g dry extract), quercetin-3-O-glucoside (0.231 ± 0.000 g/100 g dry extract), and gallic acid (0.528 ± 0.127 g/100 g dry extract) in methanol extract were performed by RP-HPLC. The phytochemical content of the active sub-fraction obtained from the leaf methanol extract by activity-guided fractionation and column chromatography studies was characterized by LC-QTOF-MS. The presence of trigalloylglucose, digalloylglucose, and methyl gallate in the G6 coded sub-fraction obtained by chromatographic techniques from the ethyl acetate sub-extract, which has the highest inhibitory effect on α-amylase and α-glucosidase enzymes, was determined by LC-QTOF-MS. In addition to the G5 coded subfraction, a strong α-glucosidase enzyme inhibitory activity was also observed in the G6 coded sub-fraction, and methyl gallate, methyl digallate, 2″-O-galloyl-quercetin-3-O-hexoside, and myricetin-3-O-hexoside were identified in this sub-fraction. This study displayed that the methanol extract of P. atlantica leaves could be a potential source for bioactive compounds with antidiabetic effects by showing inhibitory effects on enzymes involved in carbohydrate digestion.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Pekacar

Orhan

2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Recently, Achili et al. (2020) have evaluated the effect of different extracts from leaf and stem of P. atlantica Desf.…”

Section: Anticancer and Cytotoxicity Activitiesmentioning

confidence: 99%

Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Ahmed

Yousfi

Viaene

et al. 2021

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…pruinosa (Vogel) Fortunato & Wunderlin, Davallia cylindrica Ching, Pistacia atlantica Desf., Zingiber officinale Roscoe, etc. [ 85 - 92 ].…”

Section: Che Inhibitory Effect Of Quercetinunclassified

Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer’s Disease - A Promising Natural Molecule or Fashion of the Day? - A Narrowed Review

Orhan

2021

View full text Add to dashboard Cite

: Natural substances are known to have strong protective effects against neurodegenerative diseases. Among them, phenolic compounds, especially flavonoids, come to the fore with their neuroprotective effects. Since quercetin, which is found in many medicinal plants and foods, is also taken through diet, its physiological effects on humans are imperative. Many studies have been published up to date on the neuroprotective properties of quercetin, a flavanol derivative. However, there is no review published so far summarizing the effect of quercetin on the cholinesterase (ChE) enzymes related to the cholinergic hypothesis, which is one of the pathological mechanisms of Alzheimer's disease (AD). However, ChE inhibitors regardless of natural or synthetic play a vital role in the treatment of AD. Although the number of studies on the ChE inhibitory effect of quercetin is limited, it deserves to be discussed in a review article. With this sensitivity, the neuroprotective effect of quercetin against AD through ChE inhibition was scrutinized in the current review study. In addition, studies on the bioavailability of quercetin and its capacity to cross the blood-brain barrier and how this capacity and bioavailability can be increased were given. Generally, studies containing data published in recent years were obtained from search engines such as PubMed, Scopus, and Medline and included herein. Consequently, quercetin should not be considered as a fashionable natural compound and should be identified as a promising compound, especially with increased bioavailability, for the treatment of AD.

show abstract

Chemical Constituents, Antioxidant, Anticholinesterase and Antiproliferative Effects of Algerian Pistacia atlantica Desf. Extracts

Cited by 17 publications

References 28 publications

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Investigation of Antidiabetic Effect of Pistacia atlantica Leaves by Activity-Guided Fractionation and Phytochemical Content Analysis by LC-QTOF-MS

Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer’s Disease - A Promising Natural Molecule or Fashion of the Day? - A Narrowed Review

Contact Info

Product

Resources

About