Chemical Constituents from <i>Citrus changshan‐huyou</i> and Their Anti‐Inflammatory Activities

Hu, Yuhong; Liu, Jin; Li, Heng; Tang, Wei

doi:10.1002/cbdv.202000503

Cited by 14 publications

(9 citation statements)

References 26 publications

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“…NKT is one of the important bioactive integrands of the medicinal plant A. oxyphylla. It has also been isolated from the edible fruit, Citrus changshan-huyou [9,46]. It is abundantly present in fruits and peels and is easily extracted by ethanol [47,48].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

et al. 2021

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Nootkatone is one of the major active ingredients of Alpiniae oxyphyllae, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

et al. 2021

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“…Modern studies have indicated flavonoids are representative and dominant phenolic compounds isolated from CACH. Most of the flavonoids in it were in the form of flavanone glycosides, such as naringin (1), neohesperidin (4), narirutin (5), eriocitrin (7), neoeriocitrin (10), PMFs (11), and tangeretin (3) etc., (Hu et al, 2020;Zhou et al, 2021).…”

Section: Phenols and Their Derivativesmentioning

confidence: 99%

“…It grows rapidly, and its fruit expands mainly in June to July and September. Its expansion rate slows down after mid-September and harvested in November ( Hu et al, 2020 ). It has the characteristics of high yield, frost resistance, strong adaptability and storage resistance.…”

Section: Introductionmentioning

confidence: 99%

“…Qu Zhi Qiao (QZQ), the immature dry fruit of CACH, is a good source of flavonoids. Modern pharmacological studies had shown that QZQ also had effects of antioxidant ( Sun et al, 2005 ; Xu et al, 2010 ; Fang et al, 2018 ; Shi et al, 2020 ), anti-inflammatory ( Jiang et al, 2019 ; Hu et al, 2020 ), anti-tumor ( Bellocco et al, 2009 ), hypoglycemic ( Zhang et al, 2012 ), protection on organs ( Hwang and Yen, 2008 ; Vazhappilly et al, 2019 ), etc., It is a variety included in “The Processing Standards of Traditional Chinese Medicine of Zhejiang Province” (2015 Edition). In addition, it was listed as the new “Zhejiang Eight Flavors” and“Quzhou six Flavors”cultivars cultivation catalog of Zhejiang province in 2018.…”

Section: Introductionmentioning

confidence: 99%

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Citrus aurantium ‘Changshan-huyou’—An ethnopharmacological and phytochemical review

et al. 2022

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Citrus fruits are composed of oil cells layer, white membrane layer, pulp and seeds. The cultivar Citrus aurantium ‘Changshan-huyou’ (CACH) is a hybridization of Citrus grandis Osbeck and C. sinensis Osbeck. It is a rutaceae plant, and mainly grows in Changshan, Zhejiang, China. With the exploration of its high traditional values, it has been paid more and more attention by the scientific community in recent years. At present, one hundred and two chemical constituents have been identified from the pulp and peel of CACH, including volatile oils, terpenoids, phenols, limonins, sugars, etc., As the representative active component of CACH, phenols have been widely investigated. Studies have shown that CACH shows a variety of significant pharmacological activities, such as anti-inflammatory, antioxidant, hepatoprotective activity, respiratory system protection and intestinal regulation activity. This review mainly introduces the chemical constituents and pharmacological activities of CACH, and discusses its future research and development directions. It will provide theoretical basis for further research of its pharmacodynamic substances, functional mechanism and rational utilization.

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“…In addition, as authentic medicinal material, it was selected as the new "Zhejiang Eight Flavours". Citrus changshan-huyou has an excellent antiin ammatory effect, therefore, it is also commonly used in the clinical treatment of in ammatory bowel disease and enteropathy caused by NSAIDs (23). However, because of the strict processing requirements of Citrus changshan-huyou, its extract PTFC may have a better prospect for clinical promotion.…”

Section: Introductionmentioning

confidence: 99%

Pure Total Flavonoids From Citrus Ameliorate NSAIDs-Induced Intestinal Mucosal Injury via Regulation of Exosomal LncRNA H19 Expression

Chen

Liu

et al. 2023

Preprint

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Non-steroid anti-inflammatory drugs (NSAIDs) are widely used in the clinic because of their excellent antipyretic, anti-inflammatory, and analgesic effects. However, long-term use of NSAIDs will disrupt the intestinal mucosal barrier, causing erosion, ulcers, bleeding, and even perforation. How to balance the use and side effects of NSAIDs is an urgent clinical problem. Elucidating the mechanism related to disrupting the intestinal mucosal barrier caused by NSAIDs and achieving targeted drug prevention or treatment is the key. In the study, we investigated the mechanism of exosomal lncRNA H19 in the intestinal mucosal barrier injury associated with NSAIDs and the intervention of pure total flavonoids from Citrus (PTFC). Results showed that IEC-6 cells co-cultured with NSAIDs rats-derived exosomes possessed the lowest protective autophagy levels and intestinal mucosal mechanical barrier function disturbance. By contrast, though the IEC-6 cells co-cultured with the exosomes extracted from rats receiving early prevention with PTFC still exhibited a certain inhibition of autophagy and disturbance of intestinal mucosal mechanical barrier function, both were significantly better. The prevention effect was proportional to the concentration of PTFC administered. Exosomal lncRNA H19 is the critical RNA in the above mechanism, which regulates protective autophagy and intestinal mucosal mechanical barrier function.

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Chemical Constituents from Citrus changshan‐huyou and Their Anti‐Inflammatory Activities

Abstract: A systematically chemical investigation of Citrus changshan-huyou Y.B.Chang resulted in the isolation and structure determination of twelve known natural products, including limonoid,

Cited by 14 publications

References 26 publications

Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

Citrus aurantium ‘Changshan-huyou’—An ethnopharmacological and phytochemical review

Pure Total Flavonoids From Citrus Ameliorate NSAIDs-Induced Intestinal Mucosal Injury via Regulation of Exosomal LncRNA H19 Expression

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