Chemical constituents from the bark of the Cameroonian mahogany Trichilia emetica Vahl (Meliaceae)

Tsopgni, Willifred Dongmo Tekapi; Happi, Gervais Mouthé; Stammler, Hans‐Georg; Neumann, Beate; Mbobda, Alexis Sylvain W.; Kouam, Siméon F.; Frese, Marcel; Azebaze, Anatole Guy Blaise; Lenta, Bruno Ndjakou; Sewald, Norbert

doi:10.1016/j.phytol.2019.07.009

Cited by 21 publications

(7 citation statements)

References 15 publications

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“…In the structure of the ring-seco limonoids, in addition to the single ring, can be cracked; there are also cases where the two and even the three rings are cleaved at the same time, such as rings A,B-seco (B291-B402), 60,86,102,107,126,142,155,156,158,182,[192][193][194][195][196][197] rings B,D-seco (B403-B457), 56,85,90,97,135,188,190,[198][199][200][201][202][203][204][205][206][207][208][209][210] rings A,D-seco (B458-B481), 37,43,127,161,162,211,212 and rings A,B,D-seco (B482) 213 limonoids (Tables S1.8-S1.10 †). Different rotations of the C-9/C-10 single bonds of rings A,B-seco limonoids in steric crowding might cause broad or missing NMR signals, which can be solved by building new 1,n-oxygen bridges through biomimetic alkaline hydrolysis.…”

Section: Reviewmentioning

confidence: 99%

Research progress of meliaceous limonoids from 2011 to 2021

Luo

Sun

et al. 2022

Nat. Prod. Rep.

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Section: Reviewmentioning

confidence: 99%

Research progress of meliaceous limonoids from 2011 to 2021

Luo

Sun

et al. 2022

Nat. Prod. Rep.

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“…The nine isolated compounds have been identified as oxychelerythrine (1) (Fuchino et al, 2010), angoline (2) (Lee et al, 1998), arnottianamide (3) (Yang et al, 2009), hesperidin (4) (Tine et al, 2020), neohesperidin (5) (D.I. Hamdan et al, 2014), sesamin (6) (Yang et al, 2009), lupeol (7) (Jouwa et al, 2020;Tsopgni et al, 2019;Wouamba, Happi, Pouofo, et al, 2020), β-sitosterol (8) (Keugwa et al, 2021) and its derivative daucosterol (9) (Happi et al, 2020).…”

Section: Phytochemical Studymentioning

confidence: 99%

Benzo[c]phenanthridine alkaloids and glycosylated flavonoids from the roots of Zanthoxylum gilletii (Rutaceae)

Dzouemo¹,

Happi²,

Happi³

et al. 2022

NRFHH

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The roots of Zanthoxylum gilletii have been chemically investigated and led to the isolation and characterization of nine compounds including three benzo[c]phenanthridine alkaloids oxychelerythrine (1), angoline (2) and arnottianamide (3); two glycosylated flavonoids hesperidin (4) and its analogue neohesperidin (5) along with four common specialized metabolites including sesamin (6), lupeol (7), β-sitosterol (8) and its derivative daucosterol (9). Their structures were established based on their recorded 1D and 2D-NMR data. Some compounds (1, 2, 3, 6 and 7) did not display a cytotoxic activity until the highest concentration of 200 μM against the human cell lines MCF-7 and A549. The chemotaxonomic relevance of this study has been discussed. To the best of our knowledge, except for the five compounds 3, 6-9, all the four others have been for the first time isolated from Z. gilletii (Rutaceae).

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“…From seeds of T. dregeana , the limonoids include dregeana 1–4 [ 117 ]. Several limonoids from other South African Meliaceae were assigned in the stem bark of T. emetica , and previously undescribed compounds including trichirokin and trichilins A-G [ 24 , 118 ]. Then, in the genus Turraea several limonoids were also reported, such as turraflorins A–I and the floribundins A–F (names assigned in the current review, Table 3 ) from the root of T. floribunda , nilotin from the root and stem bark of T. nilotica [ 119 , 120 ] or prieurianins from seeds of T. obtusifolia [ 121 , 122 , 123 ].…”

Section: The Ethnobotany and Chemistry Of South African Meliaceaementioning

confidence: 99%

“…For example, the type, as well as common triterpenes β-amyrin, β-amyrone, oleanonic acid, lupeol, and other common sterols were reported from the wood and bark of E. pterophylla [ 108 ]. Ergosterols were isolated from twigs and leaves of P. mossambicensis [ 129 ], cycloarten-diol triterpenes from the leaves of T. dregeana [ 130 ], and sterols from the stem bark of T. emetica [ 24 ]. The common triterpene oleanolic acid and its derivatives from E. capensis demonstrated cytotoxicity against cancer cell lines and moderate antiplasmodial activity that may be related to the cytotoxic activity [ 31 ].…”

Section: The Ethnobotany and Chemistry Of South African Meliaceaementioning

confidence: 99%

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The Ethnobotany and Chemistry of South African Meliaceae: A Review

Oyedeji-Amusa

Sadgrove

Wyk

2021

Plants

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Meliaceae are widely distributed across the world in tropical or subtropical climates and are of considerable ethnobotanical importance as sources of traditional medicine and cosmetics. This comprehensive review summarizes the ethnobotanical uses and chemistry of 12 South African species, belonging to six genera: Ekebergia, Nymania, Entandrophragma, Pseudobersama, Trichilia, and Turraea. Eight of the species have ethnomedicinal records, classified into 17 major disease categories. The ethnomedicinal uses comprise 85 ailments dominated by gastrointestinal complaints, followed by gynaecological and obstetrics related problems. Chemical records were found for 10 species, which describe nine classes of compounds. In nearly all South African Meliaceae, limonoids are the predominant constituents while triterpenes, sterols, and coumarins are also common. The widest range of use-records and medicinal applications are found with the two most chemically diverse species, Ekebergiacapensis and Trichiliaemetica. Of the chemical compounds identified in the various plant organs of the 10 species of South African Meliaceae for which data are available, 42% was found in bark and 17% in seeds. Roots represent 35% and bark 33% of the organs that are used medicinally, and they are typically prepared as decoctions or infusions. Root and bark harvesting are destructive so that it may be important to examine the chemistry of plant parts such as wild-crafted leaves and fruits.

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Chemical constituents from the bark of the Cameroonian mahogany Trichilia emetica Vahl (Meliaceae)

Cited by 21 publications

References 15 publications

Research progress of meliaceous limonoids from 2011 to 2021

Research progress of meliaceous limonoids from 2011 to 2021

Benzo[<i>c</i>]phenanthridine alkaloids and glycosylated flavonoids from the roots of <i>Zanthoxylum gilletii</i> (Rutaceae)

The Ethnobotany and Chemistry of South African Meliaceae: A Review

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