Chemical constituents from Xylosma longifolia and their anti-tubercular activity

Truong, Bich Ngan; Pham, Van Cuong; Thi, Huong Doan; Nguyễn, Văn Hùng; Nguyen, Manh Cuong; Nguyên, Tiên Hiêp; Zhang, Hongjie; Fong, Harry H. S.; Franzblau, Scott G.; Soejarto, Djaja D.; Chau, Van Minh

doi:10.1016/j.phytol.2011.04.008

Cited by 12 publications

(16 citation statements)

References 14 publications

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“…In the 1 H NMR spectrum, two groups of aromatic protons signals at δ 7.49 (1H, dd, J = 1.9, 8.3 Hz), δ 7.45 (1H, d, J = 1.9 Hz), δ 6.90 (1H, d, J = 8.3 Hz), and δ 6.78 (1H, dd, J = 1.6, 8.2 Hz), δ 6.74 (1H, d, J = 8.2 Hz) and δ 6.91 (1H, d, J = 1.6 Hz) appeared as two ABX coupling systems, which belonged to two 1, 3, 4-tri-substituted aromatic rings. The 13 C NMR data of 2 were most close to those of 3-methoxy-4-hydroxyphenylpropane-7, 8-(6′-benzoyl-2′, 1′-O-β-glucopyranosyl)-7, 8, 9-triol (Truong et al, 2011), except the signals of C-3′′ and C-4′′ of 2, which are down-field by 18 and 17 ppm, respectively, indicating an ortho-dioxide substitution at 3′′ and 4′′ in 2. Their substitution position were further confirmed by the long-range correlations between δ 3.83(-OCH3) and δ 147.3(C-3′′), δ 9.03(-OH) and δ 151.7(C-4′′), and δ 7.49(H-6′′) and δ 151.7(C-4′′) in the HMBC experiment.…”

Section: Structural Elucidation Of Compoundsmentioning

confidence: 68%

Chemical constituents from the roots and stems of Stauntonia brachyanthera Hand-Mazz and their bioactivities

Zhao

Guo

Zhang³

et al. 2015

Journal of Functional Foods

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Section: Structural Elucidation Of Compoundsmentioning

confidence: 68%

Chemical constituents from the roots and stems of Stauntonia brachyanthera Hand-Mazz and their bioactivities

Zhao

Guo

Zhang³

et al. 2015

Journal of Functional Foods

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“…and Trichophyton sp. where the pathogens have developed resistance against the specific fungicides [24,26,83,84]. The development of natural antifungal agents would also help to decrease the negative impact of synthetic agents such as residues, resistance and environmental pollution.…”

Section: Discussionmentioning

confidence: 99%

“…The root extract of X. terrae-reginae , the fractions of the leaves and barks of the roots of X. ciliatifolium and methanol leaf extract X. congestum result antibacterial activity [20-23]. Two new glucosides, 3-methoxy-4-hydroxyphenylpropane-7, 8-(6′-benzoyl-2′, 1′-O-β-glucopyranosyl)-7, 8, 9-trio, and 2-hydroxyphenyl-4-caffeoyl-β-d-glucoside, together with seven known compounds are isolated from the stem bark of X. longifolia and 8-hydroxy-6-methoxy-pentylisocoumarin exhibits against Mycobacterium tuberculosis [24]. The methanolic extract of the leaves of X. longifolium isolate β-sitosterol, β-amyrin, friedelin, olean-12-en-3α-ol-28-oic acid 3α-D-glucopyranoside [25], flavonoid kaempferol-3-β-xylopyranoside-4’-α-rhamnoside [26].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-dermatophytic properties leaf and stem bark of Xylosma longifolium clos

Devi

Singh

2013

BMC Complement Altern Med

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BackgroundThe present study was carried out to assess the phytochemical and anti-dermatophytic effect of the leaf and bark extracts of Xylosma longifolium Clos. The leaf and stem bark are used by the indigenous people of Manipur, India for treatment of skin diseases.MethodsThe leaves and stem barks of Xylosma longifolium were extracted using petroleum ether, chloroform and methanol respectively. The different extracts of each plant parts were tested for antioxidant activity using DPPH assay. The phenolic content was assayed using Folin-Ciocalteu colorimetric method. Each extracts was further analysed by RP-HPLC to quantify some individual flavonoid components. The anti-dermatophytic activity was evaluated both by agar diffusion method and micro wells dilution method against the Microsporum boullardii MTCC 6059, M. canis (MTCC 2820 and MTCC 32700), M. gypseum MTCC 2819, Trichophyton ajelloi MTCC 4878, T. rubrum (MTCC 296 and MTCC 3272).ResultsThe free radical scavenging activity values were ranged from 0.7 to 1.41 mg/ml and 0.6 to 1.23 mg/ml, respectively for leaf and stem bark extracts. The amount of total phenolic contents of the extracts occurred in both leaf and bark in the range of 12 to 56.6 mg GAE/100 g and 16 to 58 mg GAE/100 g respectively. RP-HPLC analysis for flavonoids revealed the presence of two major flavonoid compounds, rutin and catechin. Kaempferol was in trace or absent. Methanol leaf extract showed significant low inhibitory effect against tested fungus Trichophyton ajelloi MTCC 4878 (0.140625 mg/ml) as the most sensitive. These finding suggest that the methanol leaf extract tested contain compounds with antimicrobial properties.ConclusionThe results of our study may partially justify the folkloric uses on the plant studied and further provide an evidence that the leaf extract of Xylosma longifolium might be indeed a potential sources of antimicrobial agents.

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“…The MIC is defined as the lowest concentration effecting a reduction in fluorescence or luminescence of 90% with respect to untreated controls. Accordingly, five of the most active plants selected from the evaluated 2066 plant extracts were carried out for bioassay-guided fractionation, which led to the isolation of 11 active compounds (Table 3 and Figure 3) including six new molecules [35,36,37,38].…”

Section: Active Agentsmentioning

confidence: 99%

Discovery of Bioactive Compounds by the UIC-ICBG Drug Discovery Program in the 18 Years Since 1998

Zhang

Fong

et al. 2016

Molecules

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Abstract:The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria. The bioassay-guided fractionation and separation of the bioactive plant leads resulted in the isolation of approximately 300 compounds of varying degrees of structural complexity and/or biological activity. The present paper summarizes the significant drug discovery achievements made by the UIC-ICBG team of multidisciplinary collaborators in the project over the period of 1998-2012 and the projects carried on in the subsequent years by involving the researchers in Hong Kong.

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Chemical constituents from Xylosma longifolia and their anti-tubercular activity

Cited by 12 publications

References 14 publications

Chemical constituents from the roots and stems of Stauntonia brachyanthera Hand-Mazz and their bioactivities

Chemical constituents from the roots and stems of Stauntonia brachyanthera Hand-Mazz and their bioactivities

Antioxidant and anti-dermatophytic properties leaf and stem bark of Xylosma longifolium clos

Discovery of Bioactive Compounds by the UIC-ICBG Drug Discovery Program in the 18 Years Since 1998

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