Chemical constituents of leaves of Senna singueana (Del.) lock

Kolawole, Opeyemi Saheed; Ms, Isyaka; M, Dahiru; Am, Gani

doi:10.22271/phyto.2021.v10.i1b.13299

Cited by 2 publications

(4 citation statements)

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“…This concurs with a past study that showed the presence of such compounds in the roots, leaves, and seeds of S. singueana [ 21 ]. This is also in accordance with a study by Kolawole et al [ 31 ], which demonstrated the presence of phenols, terpenoids, steroids, and alkaloids in ethanolic leaf extract of S. singueana .…”

Section: Discussionsupporting

confidence: 93%

“…They interfere with bacterial oxygen uptake and oxidative phosphorylation which are two important essential processes in bacteria [ 67 ]. Squalene, a triterpenoid, which had the highest concentration in the studied plant extract, has been shown to exhibit antibacterial effects [ 31 ]. Phytol, a diterpenoid, also present in the extract has known antibacterial activity [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

“…A 7-octenal,3,7-dimethyl-monoterpenoid, present in S. singu eana extract has been known to have antioxidant effects [ 96 ]. Squalene, a triterpenoid, has also been shown to possess antioxidant effects [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown to have anticancer and antimalarial effects [25]. e plant has also been used traditionally to treat inflammatory conditions, convulsions, constipation, gonorrhea, and heartburn [31]. S. singueana leaves are used to treat a variety of poultry ailments in Zimbabwe, including coccidiosis, coughing, and flu-like illnesses [32].…”

Section: Introductionmentioning

confidence: 99%

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GC-MS Analysis, Antibacterial and Antioxidant Potential of Ethyl Acetate Leaf Extract of Senna singueana (Delile) Grown in Kenya

Nyalo

Omwenga

Ngugi

2022

Evidence-Based Complementary and Alternative Medicine

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Bacterial diseases are a leading cause of mortality and morbidity globally. During bacterial diseases, an elevation of host immune response occurs, which involves the production of free radicals in response to the bacterial infection. The overproduction of free radicals in excess of the antioxidants leads to oxidative stress. Conventional antibiotics are linked to side effects such as hypersensitivity reactions in addition to bacterial pathogens developing resistance against them. Artificial antioxidants are said to be carcinogenic. This study sought to confirm folklore use and validate the antibacterial and antioxidant potential of Senna singueana which has been widely used in the Mbeere community. The in vitro antibacterial potentials of the plant extract were investigated on Bacillus subtilis ATCC 21332, Escherichia coli ATCC 25922, Salmonella typhi ATCC 1408, and Staphylococcus aureus ATCC 25923. Ciprofloxacin (100 µg/ml) drug was used as a standard reference, whereas 5% DMSO was used as a negative reference. The antibacterial tests included disc diffusion and minimum inhibitory and bactericidal concentrations. S. singueana ethyl acetate extract showed broad-spectrum potential against tested bacterial microbes producing mean zones of inhibition (MZI) from 07.67 ± 0.33 to 17.67 ± 0.33 mm. The extract demonstrated a greater effect on Gram-positive than Gram-negative bacterial pathogens. Antibacterial properties of ciprofloxacin were significantly greater in comparison to plant extract in all the dilutions ( p < 0.05 ), while 5% DMSO was inactive against all the tested bacteria. MBC values were greater than MIC values. Antioxidant properties of the extract were determined through scavenging effects of DPPH and hydroxyl radicals (•OH) as well as ferric reducing antioxidant potential (FRAP) assay. S. singueana demonstrated effects against all radicals formed. Additionally, the extract exhibited ferric reducing abilities. The extract also contained various phytocompounds with known antibacterial and antioxidant properties. This study recommends the therapeutic use of S. singueana as an antibacterial as well as an antioxidant agent.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%