Chemical Constituents of Plants from the Genus<i>Psychotria</i>

Yang, Hong-Mei; Zhang, Hongmei; Yang, Caiqiong; Chen, Ye‐Gao

doi:10.1002/cbdv.201500259

Cited by 17 publications

(9 citation statements)

References 69 publications

(215 reference statements)

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“…Steroids and terpenoids have also been reported for other Psychotria genus species (Calixto et al, 2016;Lopes et al, 2000;H. Yang et al, 2016), corroborating our findings.…”

Section: Phytochemicalssupporting

confidence: 92%

“…The majority classes of secondary metabolites in the extract, observed in the UV-visible spectra, showed maximum absorption between 220 and 420 nm, characteristics of phenolic compounds (280 nm), flavonoids (330 and 380 nm), and alkaloids (220 and 420 nm). This chemical profile is in accordance with the classes of secondary metabolites described for the Psychotria genus (Calixto et al, 2016;H. Yang et al, 2016), and even though HPLC was not used, our work is a pioneer not only for being the first to describe a whole chemical profile study with P. carthagenensis, but also to demonstrate the presence of alkaloids for this species.…”

Section: Phytochemicalssupporting

confidence: 88%

“…McKenna, 2004;Dennis J. McKenna, Towers, & Abbott, 1984;Rivier & Lindgren, 1972); for this last objective, as depurative and antirheumatic (Sanz-Biset, Campos-de-la-Cruz, Epiquién-Rivera, & Cañigueral, 2009). Additionally, the species has undergone scientific research demonstrating the efficacy of its extracts as antioxidant (Formagio et al, 2014), antifungal and antibacterial (Dias Souza et al, 2013), besides decreasing body temperature, which can be interpreted as an indication of central activity (Leal & Elisabetsky, 1996;H. Yang, Zhang, Yang, & Chen, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…As the toxic potential of a herbal remedy depends on the pharmacological characteristics and dose levels of its bioactive constituents (De Smet, 1995), the preliminary investigation of chemical constituents provides knowledge of extracts and indicates the nature of the substances present (Souza, Sena, Maranho, Oliveira, & Guimarães, 2008). For this reason, the interest in plants from the Psychotria genus has increased considerably in recent years, because it is well known for the biosynthesis of a number of bioactive alkaloids exhibiting interesting chemical traits and pharmacological activities (Calixto et al, 2016;Formagio et al, 2014;Magedans et al, 2019;Rivier & Lindgren, 1972;H. Yang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Acetylcholinesterase inhibitory potential and lack of toxicity of Psychotria carthagenensis infusions

Nascimento

Rivero-Wendt

Miranda-Vilela

et al. 2021

RSD

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We aimed to evaluate the phytochemical composition of the aqueous extract of leaves of Psychotria carthagenensis, and its possible toxicological effects at 200 µg/Kg on Rattus norvegicus. The aqueous extract was used for preliminary phytochemical analyses using standard procedures. After, male albino Wistar rats (N= 6/group) received by gavage for 15 consecutive days, infusions with fresh (FL) and dry leaf (DL) at 200 µg/kg; controls received filtered water (negative) or clonazepam solution at 0.5 mg/kg (positive). Hematological analyses, determination of serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, uric acid, total plasma protein (TPP), quantification of serum cholinesterase (AChE), and histological analyses of kidneys and liver were carried out. By the phytochemical analysis of the aqueous leaf extract, it was possible to detect the total phenols, flavonoids, tannins and alkaloids, the latter having been recorded for the species for the first time in this study. ALT and AST levels indicated an increase in these plasma enzymes, but histological analysis of kidneys and liver showed only slight changes. Inhibition of AChE levels was related mainly to alkaloids. The infusion showed the pharmacological potential of the plant as an alternative in the treatment of neurodegenerative diseases.

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“…Steroids and terpenoids have also been reported for other Psychotria genus species (Calixto et al, 2016;Lopes et al, 2000;H. Yang et al, 2016), corroborating our findings.…”

Section: Phytochemicalssupporting

confidence: 92%

Section: Phytochemicalssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acetylcholinesterase inhibitory potential and lack of toxicity of Psychotria carthagenensis infusions

Nascimento

Rivero-Wendt

Miranda-Vilela

et al. 2021

RSD

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“…Rivier and Lindgren 1972) and have proven to be a rich source of various classes of alkaloids (e.g. Calixto et al 2016;de Carvalho Junior et al 2017;Martins and Nunez 2015;Porto et al 2009;Yang et al 2016).…”

mentioning

confidence: 99%

A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

et al. 2021

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Tribes Palicoureeae and Psychotrieae (Rubiaceae, Gentianales) are complex and speciose sister groups with a pantropical distribution. Since the initial studies on ipecacuanha more than two centuries ago, species of the group have been subject to numerous phytochemical studies yielding diverse specialized ("secondary") metabolites, most of them alkaloids. However, the generic limits within the tribes have long been unclear and only recently, monophyletic genera have been delimited and segregated from a once broadly circumscribed Psychotria. Thus, a phylogeny-based and taxonomically updated review of phytochemical literature was performed which allowed assigning the bulk of phytochemical data previously reported for Psychotria to various segregate genera such as Carapichea, Eumachia and Palicourea. This review not only challenges the common perception of Psychotria as a monoterpene-indole alkaloid-rich genus. It also highlights that each of its relatives differs by accumulating specific groups of alkaloids, which is of major importance for understanding animal-plant interactions such as herbivory, as well as for drug discovery. The alkaloid complement of each of these genera is here enumerated and discussed, which should provide a framework for future studies addressing the biosynthesis, evolution, ecological and pharmacological significance of specialized metabolite differentiation in this abundant, ecologically and ethnopharmacologically important group.

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Immunological Modulation and Control of Parasitaemia by Ayahuasca Compounds: Therapeutic Potential for Chagas's Disease

Katchborian-Neto

Santos

Vilas-Boas

et al. 2022

Chemistry & Biodiversity

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Ayahuasca is a psychoactive and psychedelic decoct composed mainly of Banisteriopsis caapi and Psychotria viridis plant species. The beverage is rich in alkaloids and it is ritualistically used by several indigenous communities of South America as a natural medicine. There are also reports in the literature indicating the prophylaxis potential of Ayahuasca alkaloids against internal parasites. In the present study, Ayahuasca exhibited moderate in vitro activity against Trypanosoma cruzi trypomastigotes (IC 50 95.78 μg/mL) compared to the reference drug benznidazole (IC 50 2.03 μg/mL). The β-carboline alkaloid harmine (HRE), isolated from B. caapi, was considered active against the trypomastigotes forms (IC 50 6.37), and the tryptamine N, N-dimethyltryptamine (DMT), isolated from P. viridis was also moderately active with IC 50 of 21.02 μg/mL. Regarding the in vivo evaluations, no collateral effects were observed. The HRE alone demonstrated the highest trypanocidal activity in a dose-responsive manner (10 and 100 mg/kg). The Ayahuasca and the association between HRE and DMT worsened the parasitaemia, suggesting a modulation of the immunological response during the T. cruzi infection, especially by increasing total Immunoglobulin (IgG) and IgG1 antibody levels. The in silico molecular docking revealed HRE binding with low energy at two sites of the Trypanothione reductase enzyme (TR), which are absent in humans, and thus considered a promissory target for drug discovery. In conclusion, Ayahuasca compounds seem to not be toxic at the concentrations of the in vivo evaluations and can promote trypanocidal effect in multi targets, including control of parasitaemia, immunological modulation and TR enzymatic inhibition, which might benefit the treatments of patients with Chagas' disease. Moreover, the present study also provides scientific information to support the prophylactic potential of Ayahuasca against internal parasites.

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Chemical Constituents of Plants from the GenusPsychotria

Cited by 17 publications

References 69 publications

Acetylcholinesterase inhibitory potential and lack of toxicity of Psychotria carthagenensis infusions

Acetylcholinesterase inhibitory potential and lack of toxicity of Psychotria carthagenensis infusions

A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

Immunological Modulation and Control of Parasitaemia by Ayahuasca Compounds: Therapeutic Potential for Chagas's Disease

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