Chemical Constituents of Plants from the Genus <i>Illicium</i>

Liu, Yun-Ning; Su, Xiaohui; Huo, Changhong; Zhang, Xiping; Shi, Qing; Gu, Yu‐Cheng

doi:10.1002/cbdv.200700433

Cited by 49 publications

(32 citation statements)

References 78 publications

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“…There has been only five cycloartane triterpenoids [10], two of which were 3,4- seco -cycloartane type triterpenoids [11], isolated from family Illiciaceae. These seco -cycloartane types of triterpenoids have been extensively isolated from family Schisandraceae, especially 46 compounds of 3,4- seco -cycloartane type out of 166 triterpenoids totally [22].…”

Section: Resultsmentioning

confidence: 99%

“…However, there have been limited studies that focus on the triterpenoids from I. difengpi and of the family Illiciaceae. Until now, only six cycloartanes [6, 10, 11] were reported to be isolated from family Illiciaceae, while from family Schisandraceae ( Schisandra and Kadsura, order Illiciales) more than 150 triterpenoids [12] have been isolated. In particular, they both contain seco -cycloartane triterpenoids.…”

Section: Introductionmentioning

confidence: 99%

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Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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A pair of new 3,4;9,10-seco-cycloartane type triterpenoid stereoisomerides: 24R,25-dihydroxy-3,4;9,10-seco-4(28)-cycloarten-10,3-olide (1) named Illiciumolide A and 24S,25-dihydroxy-3,4;9,10-seco-4(28)-cycloarten-10,3-olide (2) named Illiciumolide B were isolated from the stem bark of Illicium difengpi, as well as five known biogenetically related triterpenoids, including sootepin E (3), betulinic acid (4), lupeol (5), (all-Z)-1,5,9,13,17,21-hexamethyl-1,5,9,13,17,21-cyclotertracosahexaene (6), and (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (7). The structures of two new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR, and MS techniques. Two assays were conducted: inhibition of tumor necrosis factor-alpha (TNF-α) and inhibition of nuclear factor kappa B (NF-κB) in RAW264. 7 cells induced by lipopolysaccharide (LPS). It was observed that compounds 1, 2 and 7 showed significant inhibition of TNF-α production and NF-κB release. The molecule docking results showed that compounds 1 and 2 got high fitness scores with dual specificity mitogen-activated protein kinase kinase 1 (MPKK1), whose activation plays a pivotal role between TNF-α and activation of NF-κB. The anti-HIV-1 potency of compounds 1–5 was also discussed, in addition to the results of computer-aided screening for targets.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Previous chemical investigations of the genus Illicium have resulted in the isolation of prenylated C 6 -C 3 compounds, neolignans and seco-prezizaane-type sesquiterpenes, which are characteristic chemical markers of Illicium species (Liu et al 2009). Illicium jiadifengpi is a medium-sized tree that is primarily found in South China.…”

Section: Introductionmentioning

confidence: 98%

Two new sesquiterpene lactones from the fruits ofIllicium jiadifengpi

Liu

Zhang

et al. 2015

Natural Product Research

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Two new seco-prezizaane-type sesquiterpenes, 3,4-dehydroneomajucin (1) and 1,2,3,4-tetradehydroneomajucin (2), were isolated from the fruits of Illicium jiadifengpi. The structure of these compounds was determined using 1D and 2D NMR and ESI-MS. The isolates were evaluated for their anti-hepatitis B virus activities on the Hep G2.2.15 cell line. The inhibitory rates of compounds 1 and 2 on the HBeAg and HBsAg expression were 30.08 ± 3.09% and 11.43 ± 1.92% at a concentrations of 68.00 μM and 7.88 ± 1.21% and 16.96 ± 4.24% at a concentration of 68.50 μM, respectively.

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“…The genus was previously classified as the only member of the Illiciaceae family; but later, the Angiosperm Phylogeny Group (APG) III system of 2009 included Illicium in the Schisandraceae without recognizing Illiciaceae as a distinct family 2 . Represented by evergreen trees and shrubs disjunctively distributed in North America, Mexico, Peru, the West Indies and Eastern Asia, with the highest concentration of species in Northern Myanmar and Southern China, the genus is known to contain unique secondary metabolites, such as terpenoids, phenylpropanoids, lignans and benzoquinones 3 . The fruit part of several Illicium species is particularly rich in sesquiterpenes of the secoprezizaane, anislactone, and allocedrane types 3 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical study of Illicium angustisepalum and its biological activities

Szymulanska-Ramamurthy

Zhao

Tao

2017

Acta Pharmaceutica Sinica B

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Sixteen compounds, including two new natural products (1 and 2), were obtained from the twigs of Illicium angustisepalum. The structures were elucidated based on NMR, MS, IR data and optical rotation values. Compounds 4, 5, 6 and 8 displayed moderate antibacterial activities against clinical isolates; compounds 4, 5, 8, 9 and 15 protected neural cells against oxidative stress; and compounds 10 and 14 exhibited anti-acetylcholinesterase activity.

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Chemical Constituents of Plants from the Genus Illicium

Cited by 49 publications

References 78 publications

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids fromIllicium difengpiand Their Anti-Inflammatory Activities

Two new sesquiterpene lactones from the fruits ofIllicium jiadifengpi

Phytochemical study of Illicium angustisepalum and its biological activities

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