Chemical Factory‐Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer

Abstract

In the field of nanomedicine, there is a tendency of matching designed nanomaterials with a suitable type of orthotopic cancer model, not just a casual subcutaneous one. Under this condition, knowing the specific features of the chosen cancer model is the priority, then introducing a proper therapy strategy using designed nanomaterials. Here, the Fenton chemistry is combined with zinc peroxide nanoparticles in the treatment of orthotopic liver cancer which has a “chemical factory” including that liver is the main place for iron storage, metabolism, and also the main metabolic sites for the majority of ingested substances, guaranteeing customized and enhanced chemodynamic therapy and normal liver cells protection as well. The good results in vitro and in vivo can set an inspiring example for exploring and utilizing suitable nanomaterials in corresponding cancer models, ensuring well‐fitness of nanomaterials for disease and satisfactory therapeutic effect.

Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

“…In this nano era, more and more “top-down” and “bottom-up” techniques are developed for bioengineering and biotechnology, accompanied with a series of novel functional materials such as hydrogels and new types of polymers ( Li et al, 2022b ; Zhang et al, 2022b ; Wang et al, 2022c ; Wang et al, 2022d Song et al, 2022 ; Wang and Feng, 2022 ; Zhu et al, 2022 ) and even inorganic nanoparticles ( Tang et al, 2022b ; Chen et al, 2022c ; Wu et al, 2022 ). The present protocols showed a frontier, in which the combination of a top-down electrospinning and a bottom-up of molecular self-emulsifying was explored to fabricate biomedical materials for resolving one of the most difficult challenges, i.e.…”

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

“…By HSL conversion of the response color of 1–15 mmol/L, the color phase angle of each color was obtained, and its angle value was linearly fit, yielding R 2 = 0.96707 ( Figure 9 c), which already includes the human blood glucose concentration range (3.9–6.1 mmol/L), meeting the needs for simple testing of human blood glucose. Today, new kinds of polymers [ 80 , 81 , 89 ], organic and inorganic nanoparticles [ 90 , 91 ], and novel strategies for biomedical applications [ 92 , 93 , 94 , 95 , 96 , 97 ] are continuously reported. These achievements can be borrowed into the design and development of electrospun nanofibers, and thus promote new kinds of sensors and biomedical devices.…”

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

“…Electrospun porous nanofibers have become a research hotspot, so with the progress and development of electrospinning technology and the unremitting efforts of scientists and researchers, more excellent performances of electrospun porous nanofibers can be developed. The expansion of their applications can be further strengthened along with the fast developments in modern science and technology, such as encapsulating new functional ingredients [ 182 , 183 , 184 ] and additives [ 185 , 186 ], exploring new types of filament-forming polymeric matrices [ 187 , 188 ], being introduced to popular life-improving applications [ 189 , 190 , 191 , 192 , 193 , 194 ], taking advantage of new strategies of synthesizing materials [ 195 , 196 ], and drawing support from traditional techniques for production on a large scale [ 197 , 198 ].…”