Comprehensive Physiology 1986
DOI: 10.1002/cphy.cp030340
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Chemical Mediators of Immediate Hypersensitivity Reactions

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Cited by 8 publications
(6 citation statements)
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“…Indeed, higher doses significantly decreased a reaction of hypersensitivity in guinea pigs. 5,6 In 1980, we observed similar effects in the human. Various attempts have been made at treating difficult AR patients, who were opposed to immunotherapy and/or at risk for practicing steroid treatment.…”
Section: Introductionsupporting
confidence: 60%
“…Indeed, higher doses significantly decreased a reaction of hypersensitivity in guinea pigs. 5,6 In 1980, we observed similar effects in the human. Various attempts have been made at treating difficult AR patients, who were opposed to immunotherapy and/or at risk for practicing steroid treatment.…”
Section: Introductionsupporting
confidence: 60%
“…Thus the difference observed in the action of histamine on PI-P2 concentrations in ileal and tracheal smooth muscles might be due to different experimental procedures. However, it should be kept in mind that similar treatment with 5-HT (10-M) or with ACh (10-8 M) evoked the hydrolysis of PI-P2 resulting in the synthesis of Ins-P3, in the present experiments, It is known that airway smooth muscle cells contain H2-receptors which mediate airway relaxation, in addition to HI-receptors that mediate airway constriction (Okpako et al, 1978;Drazen et al, 1978;Maengwyn-Davies, 1980). However, the hydrolysis of PI-P2 in response to histamine was not observed in the presence of cimetidine (H2-antagonist).…”
Section: Discussionmentioning
confidence: 54%
“…The specific antigen/allergen binding to IgE on mast cells results in the release of a variety of mediators associated with allergic reactions [14]. Many of the mediators released from stimulated mast cells are bronchoactive [8].…”
Section: Discussionmentioning
confidence: 99%