ChemInform Abstract: A NEW GLYCOSIDE, KUSAGININ ISOLATED FROM CLERODENDRON TRICHOTOMUM

Sakurai, Atsushi; Kato, T.

doi:10.1002/chin.198335359

Cited by 4 publications

(4 citation statements)

References 1 publication

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“…Chemical studies on this species have reported the isolation of three flavonoids (clerodendrin, clerodendroside and acetin-7-β-D-glucurono-β-(1→2)-D-glucuronide) (Morita et al, 1977), four diterpenes (clerodendren A,B,D and I) (Kato et al, 1971;Kawai et al, 1999), two blue pigments (trichotomine and trichotomine G1) (Iwadare et al, 1974) and seven phenylpropanoid glycosides (Sakurai and Kato, 1983;Kim et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves

Kim

Jung

et al. 2009

Arch. Pharm. Res.

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The chromatographic separation of MeOH extract from Clerodendron trichotomum Thunberg leaves led to the isolation of three phenylpropanoid compounds. Using spectroscopic methods, the structures of these compounds were determined as beta-(3', 4'-dihydroxyphenyl)ethyl-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-(4-O-caffeoyl)-glucopyranoside, acteoside (verbascoside) (1), beta-(3', 4'-dihydroxyphenyl)ethyl-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-(6-O-caffeoyl)-glucopyranoside, isoacteoside (2), beta-(3', 4'-dihydroxyphenyl) ethyl-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-glucopyranoside, and decaffeoylacteoside (3). We measured the anti-inflammatory activity of these three phenylpropanoid compounds both in vitro (DPPH reduction assay, TBARS assay on Cu (2+)-induced oxidized LDL, PGE(2) assay) and in vivo (acetic acid induced vascular permeability in mice and carrageenan-induced hind paw edema in rats). 80% methanol fraction and acteoside had the activity.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves

Kim

Jung

et al. 2009

Arch. Pharm. Res.

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“…Among them, six phenylethanoid glycosides (1-6) and fi ve iridoid glycosides (13-17) were obtained from this plant for the fi rst time. By comparing their MS and NMR data as well as the physical properties with the literature, their structures were identifi ed as 4″′-O-acetylverbascoside (1) (Kanchanapoom et al, 2002), verbascoside (also named kusaginin) (2) (Sakurai and Kato, 1983), cistanoside E (3) (Wu et al, 2004), martynoside (4) (Sasaki et al, 1989 ), leucosceptoside A (5) (Miyase et al, 1982), and 6″-O-acetyl-verbascoside (6) (Kanchanapoom et al, 2002), catalpol (13) (Oshio and Inouye, 1981), dihydrocatalpol (14) (Boros and Stermitz, 1990), 5,9-epi-7,8-didehydro-penstemoside (15) (Dinda et al, 2007a(Dinda et al, , 2007b, 5-hydroxy-8-epideoxyloganin (16) (Damtoft et al,1992), geniposide (17) (Ono et al, 2005). The molecular weights and chemical formulae of compounds 1 and 2 were deduced from HR-ESIMS.…”

Section: Resultsmentioning

confidence: 99%

Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius

Zhao

Norman

et al. 2009

Phytotherapy Research

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Bioassay-guided fractionation of the antibacterial ethyl acetate-ethanol (50 : 50) extract obtained from the aerial parts of Penstemon centranthifolius led to the isolation of six phenylethanoid glycosides (1-6) and eleven iridoid glycosides (7-17). Their structures were determined on the basis of spectroscopic analysis and comparison with the literature. Among them, two phenylethanoid glycosides, 4'''-O-acetylverbascoside (1) and verbascoside (2), were found to show significant inhibition of the formation of bacterial biofilms by Escherichia coli UTI89. Compound 1 showed 77% biofilm inhibition at 2.5 microg/mL, and compound 2 showed 60% inhibition at 5 microg/mL.

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“…The dried leaf and stem of C. trichotomum, known as 'Chou Wu Tong', exhibits diverse pharmacological activities such as blood pressure reduction, sedation, soothing, and paralysis activity (Huang, 1993;Ahn, 1998). Several flavonoids (Okigawa et al, 1970;Morita et al, 1977), diterpenes (Kato et al, 1971;Kawai et al, 1998;, blue pigments (Iwadare et al, 1974), sterols (Kawano et al, 1967), and phenylpropanoid glycosides (Sakurai and Kato, 1983;Kim et al, 2001) have been isolated from C. trichotomum. Activity studies have revealed antihypertensive and antioxidant effects (Chae et al, 2005), as well as an inhibitory effect on human immunodeficiency virus (HIV)-1 integrase activity (Kim et al, 2001) by C. trichotomum.…”

Section: Various Pathogenic Bacteria Including Escherichia Coli Andmentioning

confidence: 99%

Antibacterial Activity of Triterpenoids from Clerodendron trichotomum

Choi¹,

Cho²,

Lee³

et al. 2012

Journal of Applied Biological Chemistry

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The aim of this research was to investigate the antibacterial activity of Clerodendron trichotomum. Antibacterial activities of the n-hexane, methylene chloride (MC), ethyl acetate, and n-butanol fractions from C. trichotomum were tested against Staphylococcus aureus, Escherichia coli, and Helicobacter pylori. The n-hexane and MC fractions showed antibacterial activity against H. pylori at a concentration of 1.7 mg/mL and showed inhibition zones of 10 and 11 mm in disc assay, respectively. Further testing of 22-dehydroclerosterol and β-amyrin (each 3.4 mg/mL) from the MC fraction of C. trichotomum revealed moderate antibacterial effects against E. coli, S. aureus, and H. pylori. In particular, β-amyrin showed clear zones of 12 and 13 mm against E. coli and H. pylori, respectively, suggesting its potential as an antibacterial agent. The active compounds from C. trichotomum might provide a promising therapeutic agent against infections by E. coli, S. aureus, and H. pylori.

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ChemInform Abstract: A NEW GLYCOSIDE, KUSAGININ ISOLATED FROM CLERODENDRON TRICHOTOMUM

Cited by 4 publications

References 1 publication

Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves

Anti-inflammatory phenylpropanoid glycosides from Clerodendron trichotomum leaves

Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius

Antibacterial Activity of Triterpenoids from Clerodendron trichotomum

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