ChemInform Abstract: An Investigation Leading to Preparation of Tetrahydro‐quinazoline Derivatives Involving Ureidoalkylation and α‐Amidoalkylation Reactions.

Abstract

Fused pyrimidine derivatives R 0515 An Investigation Leading to Preparation of Tetrahydro-quinazoline Derivatives Involving Ureidoalkylation and α-Amidoalkylation Reactions. -Multiple substituted quinazolines (VII) are synthesized and evaluated for their effect on cardiovascular (CVS) and central nervous system (CNS). -(PANDEY*, V. K.; MUKESH; KUMAR, A.; TRIVEDI, N.; Indian J.

Quinazolinone Analogs as Potential Therapeutic Agents

“…While all the test compounds exhibited significant antihypertensive activity 3-benzyl-2-methyl-3H-[1,2,4]-triazolo[5,1-b] quinazolin-9-one (126) exhibited antihypertensive activity more than the reference standard prazocin [181]. Novel derivatives of 4-aralkyl-7-arylamido-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines (127) were designed and evaluated for their effects on CNS and CVS by Pandey et al Results showed that nicotinamido substituted quinazolines are better antihypertensive agents than pthalimido and salicylamido substituted ones [182].…”

11-(2-Oxopyrrolidin-1-ylmethyl)-1,2,3,4,5,6,11,11a-octahydropyrido[2,1-b]quinazolin-6-one dihydrate

“…Amidomethylation (Pandey et al, 2008;Ibragimov et al, 2004) of 1,2-dihydro derivatives tricyclic quinazolin-4-ones allows to enter in molecule alkyl group and to get the series of the new compounds. For this purpose is realized amidomethylation of 5,6,7,8,9,14-hexahydropyrido[2,1-d]quinazolin-11-one with N-methylolpyrrolidin-2-one.…”

“…For chemical modifications of pyrido-quinazoline alkaloids, see: . For the amidomethylation reaction of quinazolinone derivatives, see: Pandey et al (2008); Ibragimov et al (2004). For bond-length data, see: Allen et al (1987).…”

“…Alkaloid pyrido-quinazoline derivatives are widespread compounds in plants (Fitzgerald et al, 1966), was elaborated simple and convenient method of synthesis (Shakhidoyatov 1983;Barakat 1998), was studied structure and modification of pyrido-quinazoline derivatives (Tashkhodzhaev et al, 1995;Turgunov et al, 2003;Shakhidoyatov et al, 2007;Tozhiboev et al, 2007). Amidomethylation (Pandey et al, 2008;Ibragimov et al, 2004) of 1,2-dihydro derivatives tricyclic quinazolin-4-ones allows to enter in molecule alkyl group and to get the series of the new compounds. For this purpose is realized amidomethylation of 5,6,7,8,9,14-hexahydropyrido[2,1-d]quinazolin-11-one with N-methylolpyrrolidin-2-one.…”

Bis{3-(2-amino-benzilimino)-pentan-2-on oksimato}kobalt(III) sakkarinat monohidrat kompleksinin sentezi, karakterizasyonu ve teermal özellikleri

“…Kinazolin türevlerinin pek çok ve çeşitli biyolojik özellikleri, bu bileşiklerin sentezi ve kullanım alanlarının araştırılmasını yıllardır ilgi odağı haline getirmiştir. Bu grubu içeren bileşikler diüretik, antihipertansif, antibiyotik, antiinflamatuar, antikonvülsan, antibakteriyel ve antitümör gibi pek çok farmakolojik aktivite gösterirler [4][5][6][7][8][9][10][11][12].…”