ChemInform Abstract: ESCA INVESTIGATIONS ON HEAVY METAL CHELATES OF SUBSTITUTED N‐ACYL‐THIO‐ AND SELENOUREAS

Salyn, J. V.; Zumadilov, E. K.; Nefedov, V. I.; Scheibe, R.; Leonhardt, G.; Beyer, L.; Hoyer, Eberhard

doi:10.1002/chin.197741032

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As part of our continuing investigations about metal complexes with ligands derived from thiourea [ 15 – 19 ] such as thiosemicarbazones, we report here the synthesis, characterization, and antitumor activity of palladium(II) bis-chelates Pd(L 1–3 ) 2 and platinum (II) tetranuclear complex Pt 4 (L 4 ) 4 with benzaldehyde thiosemicarbazone and 4-phenyl-1-benzaldehyde thiosemicarbazone ligands, R-PhCH=N-NH-C(=S)-NHR 1 , HL 1 (R, R 1 =H), HL 2 (R= m- CN, R 1 =H), HL 3 (R= o -NO 2 , R 1 =H), and HL 4 (R=H, R 1 =Ph).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium (II) and Platinum (II) Complexes against Various Human Tumor Cell Lines

Hernándeza

Paz

Vaisberg

et al. 2008

Bioinorganic Chemistry and Applications

View full text Add to dashboard Cite

The palladium (II) bis-chelate Pd (L1−3)2 and platinum (II) tetranuclear Pt4(L4)4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (1H, 13C) spectroscopy. The complex Pd(L2)2 [HL2 = m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a transarrangement, while the complex Pt4(L4)4 [HL4 = 4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium (II) and platinum (II) complexes are more cytotoxic than their ligands with IC50 values at the range of 0.07–3.67 μM. The tetranuclear complex Pt4(L4)4, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI50 = 0.07–0.12 μM) than the other tested palladium (II) complexes.

show abstract

Section: Introductionmentioning

confidence: 99%