ChemInform Abstract: L‐Phenylalanine Cyclohexylamide: A Simple and Convenient Auxiliary for the Synthesis of Optically Pure α,α‐Disubstituted (R)‐ and (S)‐Amino Acids.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis and Solid State Conformation of Tetrapeptide Amides Containing two Aib and two (αMe)Phe Residues – Use of Enantiomerically Pure 2‐Benzyl‐2‐methyl‐2H‐azirin‐3‐amines as (αMe)Phe‐Synthons

“…[33][34][35][36][37][38] In a series of studies of model peptides consisting of Aib and Iva residues [39,40] and of Iva homopeptides [41][42][43] it was shown that there is no unambiguous correlation between the configuration of Iva and the screw sense of the helical structure. Furthermore, α-methylphenylalanine ((αMe)Phe) has been studied intensely as a prototype of chiral α,α-disubstituted α-amino acids, [44][45][46][47][48][49][50][51][52] for example the influence of its configuration on the conformation of peptides. [53][54][55][56][57][58][59] For this reason, the synthesis of 3-amino-2H-azirines with two different substituents at C(2) and their use in peptide synthesis was an attractive challenge.…”