ChemInform Abstract: Methionine Derivatives with Liver Protecting Activity.

Abstract

320ChemInform Abstract The methionine derivatives (I) are prepared by common methods. Some of these compounds have liver protecting activity against carbon tetrachloride, paracetanol, allyl alcohol, or ethionine intoxication.

Synthesis and Structural Characterization of 1- and 2-Substituted Indazoles: Ester and Carboxylic Acid Derivatives

“…was added to a solution of indazole 1 (1 eq.) in THF at 0 o C. The reaction mixture was warmed to r.t., stirred over 1 h. and then recooled to 0 o C. After 15 min., excess X(CH 2 ) n CO 2 R was added and the reaction mixture was allowed to warm to r.t. and stirred for 0.5-4 h. The solvent was removed under reduced pressure and the residue was redissolved in EtOAc, washed successively with water and brine and dried over anhydrous MgSO 4 . After filtration, the solvent was evaporated in vacuo.…”

“…Following general procedure 2, reaction of indazole 1 (3.00 g, 25.4 mmol) in DMF (10 mL), K 2 CO 3 (10.53 g, 76.18 mmol) and Br(CH 2 ) 4 CO 2 Et (4.7 mL, 33.02 mmol) for 24 h. gave compounds 2e (3.67 g, 59%) and 3e (1.95 g, 31%) as pale yellow oils. …”

“…Indazoles constitute an important class of heterocycles that display interesting biological properties [1,2], such as anti-depressant [3], anti-inflammatory [4,5], analgesic and antipyretic [6], dopamine antagonistic [7], anti-tumor [8], anti-emetic [9] and anti-HIV activities [10]. The indazole ring system is also present in many other compounds such as herbicides, dyes or sweeteners like guanidine-1H-indazole [1,2,11].…”

Synthesis and characterization of some important indazolyl derivatives

“…Thiopyrimidines and its band at 1728 for O-C=O group and 1 H nmr spectra show a sharp singlet at around 2.5 δ for -CO-CH 3 . The ir spectra of compounds 4 show a strong and characteristic band for 1,3 diketone linkage at 1620-1599 cm -1 .…”

“…Indazole compounds are capable of mediating tyrosine kinase signal transduction and thereby inhibit unwanted cell proliferation [1][2]. Indazole derivatives are examined for analgesic and anti-inflammatory activities [3]. A ruthenium coordination complex (RuInd) is one of the most effective anticancer [4] ruthenium compounds; poisoning [5] of Topoisomerase II by indazole complex was analyzed.…”