ChemInform Abstract: Pharmacology and Chemotaxonomy of Diospyros

Mallavadhani, Uppuluri Venkata; Panda, Anita; Rao, Y. R.

doi:10.1002/chin.199906268

Cited by 48 publications

(71 citation statements)

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“…However, saponins were present in small amounts and also triterpenoids but only in the AE of rainy season (Table S2). The presence of all of these compounds with the exception of saponins and other metabolites like steroids and naphthoquinones has been reported in leaves of Diospyros species reviewed by Mallavadhani et al [7]. In addition, the antifungal activity of flavonoids, triterpenoids, and saponins against crop pathogens has recently been reported [39][40][41].…”

Section: Resultsmentioning

confidence: 97%

“…Although the fungicidal effect of plant extracts obtained using different solvents is variable; aqueous extracts from plants have been more effective than methanolic and ethanolic extracts at combating fungal crop pathogens [3][4][5][6]. On the other hand, the pharmacological applications and the chemical compounds of the genus Diospyros (Ebenaceae family) have been well documented [7]. For example, aqueous extracts of Diospyros ebenaster leaves have been shown to inhibit 100% of the sporulation of Colletotrichum gloeosporioides in in vitro conditions, and the extracts have further reduced Colletotrichum gloeosporioides infections in mango, Mangifera indica, by 80% [8].…”

Section: Introductionmentioning

confidence: 99%

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Diospyros cuneata Inhibition of Fusarium oxysporum: Aqueous Extract and its Encapsulation by Ionic Gelation

Jc¹,

Peraza-Echeverrı́a²,

Rm³

et al. 2016

J Plant Pathol Microbiol

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Diospyros cuneata Inhibition of Fusarium oxysporum: Aqueous Extract and its Encapsulation by Ionic Gelation

Jc¹,

Peraza-Echeverrı́a²,

Rm³

et al. 2016

J Plant Pathol Microbiol

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“…Más de 130 especies de Diospyros se han estudiado, en las que se ha demostrado la amplia presencia de naftoquinonas (27), entre las que se destacan las O-naftoquinonas, como la α-lapachona, β-lapachona y sus análogos, y las mansononas, como sustancias citotóxicas e inhibidoras del crecimiento de tripanosomátidos (28). En este estudio se reporta por primera vez actividad tripanocida y gran citotoxicidad en el extracto en hexano de Diospyros arthantifolia.…”

Section: Muy Activosunclassified

Actividad tripanocida y citotóxica de extractos de plantas colombianas

et al. 2011

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Introducción. El tratamiento de la enfermedad de Chagas está basado en sólo dos medicamentos de eficacia limitada y con importantes efectos colaterales. La gran biodiversidad de la flora colombiana hace de la bioprospección una alternativa potencial en la búsqueda de nuevos antiparasitarios. Objetivo. Evaluar in vitro el potencial tripanocida y la citotoxicidad de extractos obtenidos de 23 plantas colombianas. Materiales y métodos. Se obtuvieron extractos de hojas, de tallos o de la planta entera, en solventes de diferente polaridad. La actividad contra epimastigotes y la citotoxicidad se evaluaron por el micrométodo enzimático con MTT. Los extractos activos contra epimastigotes y con baja citotoxicidad se evaluaron también en tripomastigotes y amastigotes intracelulares. Resultados. Se reporta la actividad tripanocida de 13 plantas colombianas y se confirma el efecto biológico de cuatro especies previamente evaluadas. Cuatro extractos activos en epimastigotes también fueron activos en tripomastigotes y, uno de ellos, en amastigotes. Este extracto fue aislado de la planta Hieronyma antioquensis, y presentó CI 50 de 3,125, 11,48 y 2,85 μg/ml, e índices de selectividad de 25, 7 y 27, para epimastigotes, tripomastigotes y amastigotes, respectivamente. Los resultados sugieren que este extracto es un candidato promisorio para el tratamiento de la enfermedad de Chagas. Conclusión. La flora colombiana es una fuente potencial de nuevas sustancias para la quimioterapia contra la enfermedad de Chagas. El micrométodo enzimático con MTT es una herramienta útil para la tamización de la actividad biológica en epimastigotes y posterior selección para ensayos con otros estadios del parásito. Palabras clave: Trypanosoma cruzi, enfermedad de Chagas, extractos vegetales. Trypanocidal and cytotoxic activity of extracts of Colombian plantsIntroduction. The treatment of Chagas disease is based on only two drugs with limited efficacy and significant side effects. The rich biodiversity of the Colombian flora makes bio-prospecting a potential alternative in the search for new antiparasitic drugs. Objective. Potential trypanocidal activity and cytotoxicity was assessed in extracts from 23 Colombian plants. Materials and methods. Extracts of leaves, stems, or of the whole plants were obtained in solvents of a range of polarities. The activity against Trypanosoma cruzi epimastigotes and the cytotoxicity were evaluated by the MTT enzymatic micro-method. Extracts active against epimastigotes and with low cytotoxicity were also tested on trypomastigotes and intracellular amastigotes. Results. Among the extracts, biological activity was confirmed in 4 species. The extracts were active on epimastigotes and trypomastigotes; one was active also against amastigotes. The latter extract was isolated from the plant Hieronyma antioquensis and presented IC 50 of 3.1 mg/ml for epimastigotes, 11.5 mg/ml for trypomastigotes and 2.9 mg/ml for amastigotes. The selectivity indexes were 25, 7, and 27 respectively.

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“…Flavonoids found in grape extract and citrus peels are known to exert health-promoting effects in humans and animals (Lien et al, 2007). Persimmon also contains many medicinally bioactive compounds, such as carotenoids, tannins and flavonoids (Mallavadhani et al, 1998). The concentrations of carotenoids and polyphenols are higher in the peels than in the pulp (Kawase et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of Fruit By-product Extracts Supplementation on Growth Performance and Nutrient Digestibility in Growing Pigs

Park¹,

Lee²,

Park³

et al. 2013

Journal of Animal Science and Technology

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A total of 96 pigs [(Landrace × Yorkshire) × Duroc] with an initial BW of 27.94 ± 0.92 kg were used in a 6-week experiment to determine the effects of dietary supplementation with fruit by-product extracts on growth performance and nutrient digestibility in growing pigs. Pigs were randomly allotted to four treatments : 1) CON (basal diet), 2) PRO (CON + 0.5% procyanidin), 3) HES (CON + 0.5% hesperidin), 4) TAN (CON + 0.5% tannin). There were six replications per treatment with four pigs per pen. Supplementation had no effect (p>0.05) on average daily gain, average daily feed intake, and G/F. The apparent total tract digestibility (ATTD) of dry matter and nitrogen was increased (p<0.05) in the HES treatment relative to the PRO treatment. Pigs fed the HES and TAN diets had greater (p<0.05) ATTD of energy than pigs fed PRO diet. The ATTD of ash was greatest (p<0.05) in HES treatments. In addition, the ATTD of calcium was greater (p<0.05) in HES treatments than in CON and PRO treatments. Overall, the results of this study indicated that dietary supplementation with 0.5% fruit by-products did not affect growth performance, but inclusion of 0.5% hesperidin increased nutrient digestibility in growing pigs.

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ChemInform Abstract: Pharmacology and Chemotaxonomy of Diospyros

Cited by 48 publications

References 1 publication

Diospyros cuneata Inhibition of Fusarium oxysporum: Aqueous Extract and its Encapsulation by Ionic Gelation

Diospyros cuneata Inhibition of Fusarium oxysporum: Aqueous Extract and its Encapsulation by Ionic Gelation

Actividad tripanocida y citotóxica de extractos de plantas colombianas

Effects of Fruit By-product Extracts Supplementation on Growth Performance and Nutrient Digestibility in Growing Pigs

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