ChemInform Abstract: Solvent‐Free Synthesis of Dihydropyridines and Acridinediones via a Salicylic Acid‐Catalyzed Hantzsch Multicomponent Reaction.

Abstract

Solvent-Free Synthesis of Dihydropyridines and Acridinediones via a Salicylic Acid-Catalyzed Hantzsch Multicomponent Reaction. -Salicylic acid is found to be an extremely useful and highly efficient catalyst for the synthesis of the title compounds (III) and (VI) by three-component condensation of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate. -(KHODJA, I. A.; GHALEM, W.; DEHIMAT, Z. I.; BOULCINA, R.; CARBONI, B.; DEBACHE*, A.; Synth. Commun. 44 (2014) 7, 959-967, http://dx.

Salicylic Acid as a Bio-Based, Natural and Versatile Catalyst for Green, Solvent-Free and One-Pot Biginelli Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one/thione Derivatives

“…[12]. In recent decades, a number of methodologies for preparing these compounds have been reported that is including various catalysts [13][14][15][16][17][18][19][20][21][22][23], some of the limitations of these methodologies are low yields, toxic organic solvents and catalyst, harsh reaction conditions and expensive materials. In recent years, the design and development of bioactive heterocyclic compounds synthesis performed through multi-component reactions (MCRs) [24][25][26][27][28], involving three or more reactants in one-pot, have attracted considerable interest since such processes have improved atom economy, efficiency and convergence.…”

Phthalic Acid: A Green, Biodegradable and Environmentally Benign Nature Di-Functional Brønsted Acid Catalyst for the One-Pot Synthesis of 3, 4-Dihydropyrimidin-2- (1h)-One Derivatives and Substituted Dihydro-2-Oxypyrroles

“…Recently, because of their specially pharmaceutical and biological activities, compounds with pyrrole rings such as dihydro-2-oxypyrroles and Biginelli [5] reactions for the synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones derivatives have attracted much interest in the organic researches for example these compounds have been used as anticancer [6], calcium channel blockers, α-1a-antagonists [7], human cytomegalovirus ( HCMV) protease [8], they has been used as Pl-091 [9], many of number alkaloids with biological activities have pyrrole rings [10], And these rings have been used as UCS1025A [11]. In the recent years, several protocols for the preparation of these compounds that is including bronsted or lewis acid catalysts have been reported for example Cu(OAc) 2 [12], [Btto][p-TSA] [13], bakers , yeast [14], Calcium Fluoride [15], copper(II) tetrafluoroborate [16], hydrotalcite [17], TBAB [18], hexaaquaaluminium(III) tetrafluoroborate [19], copper(II)sulfamate [20], I 2 [21], AcOH [22], [n-Bu 4 3 [24], oxalic acid [25], ZrCl 4 [26], InCl 3 [27]. Some of limitation these methodologies are low yields, toxic catalyst, long time reactions, harsh reaction conditions, expensive materials.…”