ChemInform Abstract: Structures of the Bioxalomycins and Their Relationship to Naphthyridinomycin.

Zaccardi, J.; Alluri, Mahender R.; Ashcroft, Joseph; Bernan, Vernan S.; Korshalla, Joseph D.; Morton, George O.; Siegel, Marshall M.; Tsao, Rushung; Williams, D. R.; Maiese, William M.; Ellestad, George A.

doi:10.1002/chin.199504277

ChemInform

1995

DOI: 10.1002/chin.199504277

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ChemInform Abstract: Structures of the Bioxalomycins and Their Relationship to Naphthyridinomycin.

J. Zaccardi¹,

Mahender R. Alluri²,

Joseph Ashcroft³

et al.

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

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2001

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Bioxalomycins, new antibiotics produced by the marine Streptomyces sp. LL-31F508. Taxonomy and fermentation.

Bernan¹,

Montenegro²,

Korshalla³

et al. 1994

J. Antibiot.

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An actinomycete strain designated LL-3 1F508 was isolated from an intertidal sediment sample collected in Key West, Florida. Culture LL-31F508 was assigned to the Streptomyces genus based on the presence of LL-diaminopimelic acid (DAP)in the cell wall and observations of spiny spores using scanning electron microscopy (SEM). Excellent antimicrobial activity against Staphyloccoccus and Enterococcusspp. weredetected in both the supernatant and cell extract samples from fermentations of culture LL-31F508. Production of antibiotic activity peaked at 48~50 hours and closely paralleled cell growth, during which time glucose was more rapidly assimilated than dextrin. A series of new antibiotics called the bioxalomycins was identified as the antibacterial products from fermentations of this culture. Fermentation conditions for production of bioxalomycin a differed substantially from those required for production of a related compound, naphthyridinomycin, by the reference culture Streptomyces lusitanus NRRL8034.

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Bioxalomycins, new antibiotics produced by the marine Streptomyces sp. LL-31F508. Taxonomy and fermentation.

Bernan¹,

Montenegro²,

Korshalla³

et al. 1994

J. Antibiot.

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New Naphthyridinomycin-type Antibiotics, Aclidinomycins A and B, from Streptomyces halstedi.

Cang¹,

Ohta²,

Chiba³

et al. 2001

J. Antibiot.

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In a search for new antitumor substances as a rec-active antibiotic using a modified rec assay,1>2^we found that Streptomyces halstedi KB012 isolated from a sea sand sample collected from Yasuura seashore (Hiroshima) produced a rec-active antibiotic that exhibited more growth inhibition on a recombination-deficient (rec~) strain than a proficient (rec") strain of Bacillus subtilis. TLCof the crude-solvent extract from the culture broth revealed that the active entity consisted of at least six yellow spots. However, four of these components were quite labile, so that our efforts to isolate each pure component were unsuccessful.

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ChemInform Abstract: Structures of the Bioxalomycins and Their Relationship to Naphthyridinomycin.

Cited by 2 publications

References 1 publication

Bioxalomycins, new antibiotics produced by the marine Streptomyces sp. LL-31F508. Taxonomy and fermentation.

Bioxalomycins, new antibiotics produced by the marine Streptomyces sp. LL-31F508. Taxonomy and fermentation.

New Naphthyridinomycin-type Antibiotics, Aclidinomycins A and B, from Streptomyces halstedi.

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