ChemInform Abstract: Studies on Synthesis and Antibacterial Activity of Some New Schiff Bases, 4‐Thiazolidinones and 2‐Azetidinones.

Pawar, Rajendra P.; Andurkar, N. M.; Vibhute, Yeshwant B.

doi:10.1002/chin.200019114

Cited by 9 publications

(10 citation statements)

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“…Kumar et al have synthesized 3-(3-chloro-2-oxo-4-substitutedaryl-azetidin-1-yl)-2-(5-pyridin-4-yl- [1,3,4]-oxadiazol-2-yl-sulfan ylmethyl)-substituted-3H quinazolin-4-ones derivatives [93] and evaluated for their anti-inflammatory activity. All the compounds exhibited anti-inflammatory activity at the dose 50 mg/kg p.o.…”

Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 99%

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2-Azetidinone – A new profile of various pharmacological activities

Mehta

Sengar

Pathak

2010

European Journal of Medicinal Chemistry

190

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Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 99%

“…Bhati has prepared various 3-chloro-4-aryl-1-{5-[{ [1,3,4]thiadiazino [6,5-b]indol-3-ylamino]methyl]-1,3,4-thiadiazol-2-yl}aze-tidin-2-one derivatives [92]. The structures of these newly synthesized compounds were confirmed by their analytical and spectral data.…”

Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 99%

2-Azetidinone – A new profile of various pharmacological activities

Mehta

Sengar

Pathak

2010

European Journal of Medicinal Chemistry

190

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“…Azetidines are widely used in the areas of fine chemicals and medical substrates. Azetidines principally possess anti-inflammatory, analgesic, 11,12 antibacterial, 13,14 antifungal, 15,16 antitumour 17,18 and antimalarial 19,20 activities. So far, several synthetic methods have been tabled for the synthesis of Schiff bases and azetidines.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in-vitro Antioxidant Activity of Novel Schiff Bases and Azetidines Derived from Phenyl Urea Derivatives

Nagavolu¹,

Velusamy²,

Chechugari³

et al. 2017

IJPER

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Objective: The Schiff bases and azetidines are important intermediates used in synthesis of several therapeutics and medicinally contributing molecules. This research was focused on synthesis of Schiff bases and azetidines, characterization and subsequent evaluation of their in-vitro antioxidant potentials. Methods: In this work, the Schiff bases and azetidines were derived from phenyl urea derivatives. They were tested qualitatively for melting point and characterized by TLC, FTIR, 1H-NMR, 13 C-NMR and GCMS for their chemical structures. The Schiff bases and azetidines were screened for in-vitro antioxidant activity by employing hydrogen peroxide free-radical inhibition method. Results: The compounds 1-[(1E)-2-(3-fluorophenyl) ethylidene]-3-(4-ethoxyphenyl) urea and3-chloro-2-(3-fluorophenyl)-N-(4-methoxyphenyl)-4-oxoazetidine-1-carboxamide were derived by nucleophilic addition and cycloaddition reactions and had displayed moderate to significant antioxidant effects compared to ascorbic acid. Thus, medicinally and chemically important Schiff bases and azetidines were synthesized successfully. Conclusion:The present research can be a base to explore further simple and easy means of other synthetic schemes in processing of complex and potent bulk chemicals as well as medicinal agents.

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“…Particularly, the role of β‐lactam ring is endowed with unique structure and potent antibacterial activity. The 2‐azetidinone (β‐lactam) ring system is the common structural feature of a number of broad spectrum β‐lactam antibiotics, including penicillins, cephalosporins, carbapenems, nocardicins, monobactams, clavulanic acid, sulbactams, and tazobactams, which have been widely used as chemotherapeutic agents to treat bacterial infections and microbial diseases . Most of the researches up to early 1990s focused on synthesis of 2‐azetidinones and study of their antibacterial property.…”

Section: Introductionmentioning

confidence: 99%