ChemInform Abstract: Synthesis of Novel Bis‐1,3,4‐thiadiazoles, Bis‐1,2,4‐triazoles and Their Antimicrobial Activity.

Abstract

Thiadiazole derivatives R 0300Synthesis of Novel Bis-1,3,4-thiadiazoles, Bis-1,2,4-triazoles and Their Antimicrobial Activity. -Some of the novel title compounds are highly active against E. coli, B. subtilis and S.

Synthesis, Characterization and Pharmacological Screening of Some Substituted 1,2,3- & 1,2,4-Triazoles

“…The infrared spectra of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) showed the characteristic absorption bands of >C=N and C-N of triazole ring at 1562-1598 cm -1 and 1313-1365 cm -1 respectively, which confirmed the formation of triazole ring.…”

“…The biological profile of triazoles derivatives is very extensive [1][2][3] . Compounds bearing a symmetrical triazole moiety are reported to show a broad spectrum of pharmacological activities such as antibacterial [4][5][6][7] , antifungal [8][9][10][11] , antimicrobial [12][13][14] , antimycobacterial [15][16] , antioxidant 17 , analgesic 18,19 , antipyretic 20 , anticancer [21][22] , anticonvulsant 23 and anti-inflammatory [24][25][26] activities.…”

A Green Methodology for the Synthesis of Some Regioselective 1, 4‐Disubstituted 1,2,3‐Triazoles via Laccase‐Mediated Click Reaction.

“…Synthesis of 1,2,3-triazole derivatives has always been an area of significant concern from both research and industrial point of view as they serve as vital intermediates in the manufacturing of most of the pharmaceutically important scaffolds and advanced materials. [1] Further curiosity for the synthesis of triazole derivatives stems from their biological activities such as antifungal, [2,3] antibacterial, [4][5] anti-HIV, [6][7] herbicidal, antioxidant, [8] and anti-inflammatory, [8] etc. They are also actively employed as catalysts and ligands in transition metal catalysis.…”