ChemInform Abstract: Synthesis of Some New 4,6‐Disubstituted 1,2,4‐Triazin‐3,5(2H)‐diones and Related Compounds of Potential Antifungal Activity.

Abdel‐Rahman, Reda M.; Seada, M.; El-Gendy, Z.; Islam, I. E.; Mahmoud, Maha

doi:10.1002/chin.199412229

Cited by 4 publications

(4 citation statements)

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“…anti-protozoal [ 14 ], antitumor [ 15 ], antitubercular with antimycobacterial activity [ 16 ]. On the other hand, the 1,2,4-triazine moiety has also attracted the attention of chemists because many 1,2,4-triazines are biologically active [ 17 , 18 , 19 , 20 , 21 , 22 ] and are used in medicine, especially as anti AIDS, anticancer [ 23 , 24 ], and antitubercular agents [ 25 ], for their anti-anxiety and anti-inflammatory activities [ 26 , 27 ], as well as in agriculture [ 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Anticancer Activity of Some New S-Glycosyl and S-Alkyl 1,2,4-Triazinone Derivatives

Saad

Moustafa

2011

Molecules

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A series of S-glycosyl and S-alkyl derivatives of 4-amino-3-mercapto-6-(2-(2-thienyl)vinyl)-1,2,4-triazin-5(4H)-one (1)were synthesized using different halo compounds such as preacetylated sugar bromide, 4-bromobutylacetate, 2-acetoxyethoxy-methyl bromide, 3-chloropropanol, 1,3-dichloro-2-propanol, epichlorohydrin, allyl bromide, propargyl bromide, phthalic and succinic acids in POCl3. The structures of the synthesized compounds have been deduced from their elemental analysis and spectral (IR, 1H-NMR, and 13C-NMR) data. Some of the synthesized compounds were screened as anticancer agents. Significant anticancer activities were observed in vitro for some members of the series, and compounds 4-Amino-3-(3-hydroxypropylthio)-6-(2-(2-thienyl)vinyl)-1,2,4-triazin-5(4H)-one (12) and 3-(4-Oxo-3-(2-(2-thienyl)vinyl)-4H-[1,3,4]thiadiazolo-[2,3-c][1,2,4]tr-iazin-7-yl)propanoic acid (18) are active cytotoxic agents against different cancer cell lines.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Anticancer Activity of Some New S-Glycosyl and S-Alkyl 1,2,4-Triazinone Derivatives

Saad

Moustafa

2011

Molecules

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“…The biological activities of 1,2,4-triazines have attracted the attention of many chemists because numerous 1,2,4-triazines are biologically active [ 12 , 13 , 14 , 15 , 16 , 17 ] and are used in medicine, especially as anti AIDS agents, anticancer agents [ 18 , 19 ], antitubercular agents [ 20 ], potent CRF receptor antagonists [ 21 ], cathepsin K inhibitors [ 22 ], and for their anti-anxiety and anti-inflammatory activities [ 23 , 24 ], as well as in agriculture [ 25 , 26 , 27 , 28 ]. They also form complexes with metal ions which are used for metal determination.…”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity

2011

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Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4]triazinone and pyrazolo[5,1-c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS2/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, 1H-NMR, 13C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.

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“…The triazine moiety has also attracted the attention of chemists because many triazines are biologically active and are used in medicine, especially as anti-AIDS, anticancer, and antitubercular agents, for their anti-anxiety and anti-inflammatory activities, as well as used in agriculture [97][98][99].…”

Section: The Triazine Functional Groupmentioning

confidence: 99%

Current Research on Antiepileptic Compounds

2015

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Epilepsy affects about 1% of the world's population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.

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ChemInform Abstract: Synthesis of Some New 4,6‐Disubstituted 1,2,4‐Triazin‐3,5(2H)‐diones and Related Compounds of Potential Antifungal Activity.

Cited by 4 publications

References 0 publications

Synthesis and Anticancer Activity of Some New S-Glycosyl and S-Alkyl 1,2,4-Triazinone Derivatives

Synthesis and Anticancer Activity of Some New S-Glycosyl and S-Alkyl 1,2,4-Triazinone Derivatives

Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity

Current Research on Antiepileptic Compounds

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