Chemistry and Biological Activity of Tetrahydrocannabinol and its Derivatives

Flemming, T.; Muntendam, Remco; Steup, C.; Kayser, Oliver

doi:10.1007/7081_2007_084

Cited by 22 publications

(32 citation statements)

References 133 publications

(162 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cannabis sativa L. (marijuana) is an annual herb which is the natural source of cannabinoids, a unique class of terpeno-phenolic compounds which accumulate mainly in the glandular trichomes of the plant (Flemming et al 2007). Besides its psychoactivity, the major biologically active compound, Δ 9 -tetrahydrocannabinol (Δ 9 -THC) commonly referred as THC possesses analgesic, anti-inflammatory, appetite stimulant and anti-emetic properties making this cannabinoid a very promising drug for therapeutic purposes, especially for cancer and AIDS patients (Sirikantaramas et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Temperature response of photosynthesis in different drug and fiber varieties of Cannabis sativa L.

Chandra

Lata

Khan

et al. 2011

Physiol Mol Biol Plants

View full text Add to dashboard Cite

The temperature response on gas and water vapour exchange characteristics of three medicinal drug type (HP Mexican, MX and W1) and four industrial fiber type (Felinq 34, Kompolty, Zolo 11 and Zolo 15) varieties of Cannabis sativa, originally from different agro-climatic zones worldwide, were studied. Among the drug type varieties, optimum temperature for photosynthesis (T opt ) was observed in the range of 30-35°C in high potency Mexican HPM whereas, it was in the range of 25-30°C in W1. A comparatively lower value (25°C) for T opt was observed in MX. Among fiber type varieties, T opt was around 30°C in Zolo 11 and Zolo 15 whereas, it was near 25°C in Felinq 34 and Kompolty. Varieties having higher maximum photosynthesis (P N max ) had higher chlorophyll content as compared to those having lower P N max . Differences in water use efficiency (WUE) were also observed within and among the drug and fiber type plants. However, differences became less pronounced at higher temperatures. Both stomatal and mesophyll components seem to be responsible for the temperature dependence of photosynthesis (P N ) in this species, however, their magnitude varied with the variety. In general, a two fold increase in dark respiration with increase in temperature (from 20°C to 40°C) was observed in all the varieties. However, a greater increase was associated with the variety having higher rate of photosynthesis, indicating a strong association between photosynthetic and respiratory rates. The results provide a valuable indication regarding variations in temperature dependence of P N in different varieties of Cannabis sativa L.

show abstract

Section: Introductionmentioning

confidence: 99%

Temperature response of photosynthesis in different drug and fiber varieties of Cannabis sativa L.

Chandra

Lata

Khan

et al. 2011

Physiol Mol Biol Plants

View full text Add to dashboard Cite

show abstract

“…The major secondary metabolites of C. sativa L. constitute cannabinoids, terpenoids, flavonoids, alkaloids, and lignans (Flores-Sanchez (Flemming et al 2007). However, these phytochemicals are more concentrated in a viscous resin that is produced in glandular trichomes.…”

Section: Overview Of Phytocannabinoidsmentioning

confidence: 99%

Recent Advances in Research on Cannabis sativa L. Endophytes and Their Prospect for the Pharmaceutical Industry

Kusari

Spiteller

Kayser

et al. 2014

Microbial Diversity and Biotechnology in Food Security

Self Cite

View full text Add to dashboard Cite

Endophytic microorganisms residing within plants are constantly communicating with them and the external environment by means of various interaction mechanisms and biochemical processes. Although plants have evolved their own defense mechanisms, sometimes they fail to defend themselves from the constant attack of devastating and emerging pathogens. Thus, research involving endophytes that aid the defense responses of their host plants can be useful in biocontrol and pest management strategies. Elucidating the chemistry of endophyte-plant interactions can provide new insights into the production of target and/or nontarget metabolites, thereby enabling a better understanding of the metabolic processes in planta and ex planta. In this chapter, we highlight the interactions of endophytes harbored in the medicinally important plant Cannabis sativa L. with the host plant as well as with the pathogens. The various endophyte-plant-pathogen defense-counter defense crosstalk would aid in exploring the biocontrol potential of endophytes in thwarting pathogens attacking the plants, and thus, effectively decrease the loss of such therapeutically relevant medicinal plants. Such interactions will further lead to the discovery of bioactive compounds, including the ones exclusive to the host plants. This chapter deals with the recent advances made

show abstract

“…These structures are present in cannabinoids, which are benzopyran derivatives obtained from Cannabis sativa . In particular, the psychoactive Δ 9 ‐tetrahydrocannabinol and their derivatives are important in biomedicine and pharmacy 2. The structurally related chromenones and pyranocoumarins are also found in various polycyclic compounds, which are widely distributed in nature and show a broad spectrum of biological activities including antibacterial, antimalarial, anticoagulant and anti‐HIV activities 3.…”

Section: Introductionmentioning

confidence: 99%