Chemistry and Biological Activity of Condamineeae Tribe: A Chemotaxonomic Contribution of Rubiaceae Family

Abstract

This study is a review of the Condamineeae tribe, through the acquisition of data from phytochemical studies and evaluation of genera activities that constitute the tribe, in order to contribute to chemotaxonomic classification of this tribe in the Rubiaceae family. This review also states the scarcity of phytochemical investigations of several genera and consequently a lot of species of family.

Natural Products from Endophytic Fungi Associated with Rubiaceae Species

“…-dihydroxybut-3-enyl)-5H-furan-2-one (21) and (2E,4R)-2,4dimethylnon-2-enoic acid (22); seven phenolic derivatives: p-hydroxyphenyllactic acid (23), phenyllactic acid (24), p-hydroxybenzoic acid (25), p-hydroxybenzaldehyde (26), n-butyl-3,4dihydroxybenzoate (27), n-hexyl-3,4-dihydroxybenzoate (28) and n-octyl-3,4-dihydroxybenzoate (29); and the known compound (2E,4S)-2,4-dimethyloct-2-enoic acid (30) ( Figure 5) [102]. Extracts of solid cultures of Sporormiella minimoides (Sporormiaceae), isolated as an endophytic fungus from leaves Hintonia latiflora collected in Mexico, yielded five polyketides, 3,6-dimethoxy-8methyl-1H,6Hbenzo[de]isochromene-1,9-dione (31), 3-hydroxy-1,6,10-trimethoxy-8-methyl-1H,3Hbenzo[de]isochromen-9-one (32), 5-hydroxy-2,7-dimethoxy-8-methylnaphthoquinone (33), minimoidiones A (34) and B (35), along with four known compounds: corymbiferone (36), ziganein (37), brocaenol B (38) and preussochromone C (39) [103][104][105]. Two other compounds, 9S,11R(+)-ascosalitoxin (40) and vermelhotin (41), were also produced by endophytes from this plant [105,106].…”

“…Metabolites produced by S. minimoides were evaluated as potential human calmodulin (hCaM) inhibitors, and two compounds, 5-hydroxy-2,7-dimethoxy-8-methylnaphthoquinone (33) and vermelhotin (41), quenched the extrinsic fluorescence of this biosensor significantly, with dissociation constant (Kd) values of 1.55 µM and 0.25 µM, respectively. The docking displayed studies to predict the interaction of 33 with hCaM and many hydrophobic interactions with Phe19, Phe68, Met51, Met71, Met72 and Ile52.…”

“…Diverse species of Rubiaceae have widespread use in folk medicine, and some of them showed anti-inflammatory, analgesic, antibacterial, mutagenic, antiviral, and antioxidant activities. Besides, an effect on vascular diseases and action on the central nervous system were observed [ 25 , 27 , 33 , 34 ].…”

Anticholinesterase Activity and Mass Spectral Analysis of Olea dioica Roxb., An in vitro Study

“…Phytochemical studies of the methanol leaf extract showed the presence of several flavonoids and phenolic compounds. The leaf extract also harboured other bioactive compounds such as tannins, sterols and saponins (Table 1) but protein was absent in the methanol leaf extract [31] . The UV-spectroscopy gives qualitative and quantitative measurements of plant secondary metabolites and helps characterise the detailed chemistry of the compound.…”

Angelocunhol: New Erythroxylane Diterpene and Other Compounds fromSimira sampaioana(Rubiaceae)

“…Many of these species have been used by diverse communities as coloring producers, antifebrile, tonic and purgative substances, and by the phototoxic activities presented by some of their chemical constituents. [1][2][3][4] Simira sampaioana (synonyms Sickingia sampaioana in the Atlantic Rainforest) is known by its common names "arariba", "canela-samambaia", "marfim" and "maiate", and economic interest is justified by use as timber and for the afforestation of streets. 1,5 As the first phytochemical study involving S. sampaioana, this article describes the isolation and structural characterization of the new diterpene 11β,12α-dihydroxy-2,4(18),15-eritroxilatrien-1-one, named Angelocunhol (1), together with 14 known compounds: simirane B (2), harman (3), maxonine (4), isomalindine (5), malindine (6), sitost-4-en-6-ol-3-one (7), estigmast-4,22-dien-6-ol-3-one (8), campest-4-en-6-ol-3-one (9), sitost-4-en-3-one (10), stigmast-4,22-dien-3-one (11), campest-4-en-3-one (12), β-sitosterol (13), stigmasterol (14), and stigmast-4,22-dien-3-ol (15) (Figure 1) from the wood of the plant.…”