Chemistry of Biologically Active Sulfur Compounds

Kharasch, Norman; Arora, Ajit S.

doi:10.1080/03086647608078930

Cited by 25 publications

(8 citation statements)

References 704 publications

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“…7,8 Dehydroascorbic acid, flavins, cytochromes oxidizes thiols to control the cellular redox potential and prevent oxidative damage in biological systems. [9][10][11] We report herein the synthesis and characterization of metal complexes containing bis(2-bromophenyl)disulfide as a ligand.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Bis(2-Bromophenyl)disulfide Complexes

Anacona

Gómez

2008

J. Chil. Chem. Soc.

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Section: Introductionmentioning

confidence: 99%

Transition Metal Bis(2-Bromophenyl)disulfide Complexes

Anacona

Gómez

2008

J. Chil. Chem. Soc.

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“…GSH can be either spontaneously or enzymatically oxidized to the disulfide form, GSSG, under culture conditions [19]. Since GSSG has been shown to be a potent inhibitor of protein synthesis [20], we tested the possibility that 2-ME might reverse the cumulative inhibitory effects of this compound in the cultures.…”

Section: Gssgmentioning

confidence: 99%

Enhancement of the primary antibody response by 2‐mercaptoethanol is mediated by its action on glutathione in the serum

Hoffeld

Oppenheim

1980

Eur J Immunol

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2-Mercaptoethanol (2-ME) is widely used in rodent lymphoid cell cultures as an enhancer of multiple cellular functions. We have confirmed that the action of 2-ME must be on a serum component(s), rather than a direct action on the cells. The serum component(s) is contained within the dialyzable fraction of fetal calf serum (FCS) since: (a) dialysis of FCS diminished the ability of FCS to support an antibody response even in the presence of 2-ME; and (b) FCS dialysate, pulsed with 2-ME, restored the ability of dialyzed FCS to support an antibody response. Diminution of the reduced glutathione content of FCS by heating reduced the capacity of FCS to support an antibody response, whereas addition of 2-ME-pulsed glutathione restored the supportive capacity of heated FCS. Conversely, oxidized glutathione inhibited the antibody response in the absence of 2-ME, but that inhibition was not seen in the presence of 2-ME. We have concluded that reduced glutathione is an essential component in FCS in order for 2-ME to produce its enhancing effect. The most plausible explanation for the enhancement of antibody responses, in vitro, by 2-ME, is the concomitant reversal of the inhibitory effect of oxidized glutathione and the increased availability of reduced glutathione which can scavenge oxygen-derived radicals, thus protecting macrophages and lymphocytes from the deleterious effects of oxygen-derived free radicals.

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“…1,2 Dehydroascorbic acid, flavins, and cytochromes oxidize thiols to control the cellular redox potential and prevent biological oxidative damage. [3][4][5] On the other hand, certain organic disulfides are used as additives for lubricating oils, since their presence increases the load-bearing properties of oil, especially at high pressures. 6 The formation of diphenyl disulfide 7,8 as well as dibenzyl disulfide 9 and their molecular structures are well characterized.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization, and Crystal Structure of Two Polymorphs of o,o’-Dichloro Dibenzyl Disulfide

Srivastava

Rastogi

Rajaram

et al. 2010

Phosphorus, Sulfur, and Silicon and the Related Elements

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2-Chlorophenyl methanethiol undergoes air oxidation catalyzed by different selenides andyields the corresponding disulfide 1 in two polymorphic forms, 1a and 1b. In the molecular structures of the two new polymorphs of o,o -dichloro dibenzyl disulfide, the dihedral angles between the dibenzyl groups are 82.0(1) • , (1a), and 73.7(4) • , (1b), respectively [(1a): P-1, a = 8.424(2) Å, b = 8.838(2) Å, c = 10.5823(19) Å, α = 90.122(18) • , β = 112.19(2) • , γ = 95.19(2) • , V = 725.9(3) Å 3 ; (1b): P2 1 /n, a = 10.5888(10) Å, b = 9.1590(6) Å, c = 15.2489(14) Å, β = 103.072(9) • , V = 1440.6(2) Å 3 ]. MOPAC computational studies yield dihedral angles of 89.6(5) • and 71.9(9) • . Crystal packing is stabilized by weak π -ring (C H· · ·Cg) intermolecular interactions in both 1a and 1b and by additional weak Cg · · · Cg intermolecular interactions in 1b, which influence the bond distances, bond angles, and torsion angles of the dibenzyl groups in each polymorph. Additional characterization of each polymorph has been carried out by TEM, IR, 1 H and 13 C NMR spectroscopy, microanalysis, and by FAB mass spectrometry. TEM studies of a sample of 1a show that it contains cigar-shaped crystallites.

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Chemistry of Biologically Active Sulfur Compounds

Cited by 25 publications

References 704 publications

Transition Metal Bis(2-Bromophenyl)disulfide Complexes

Transition Metal Bis(2-Bromophenyl)disulfide Complexes

Enhancement of the primary antibody response by 2‐mercaptoethanol is mediated by its action on glutathione in the serum

Synthesis, Spectral Characterization, and Crystal Structure of Two Polymorphs of o,o’-Dichloro Dibenzyl Disulfide

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