Chemistry of Lipid Peroxidation Products and Their Use as Biomarkers in Early Detection of Diseases

Yoshida, Yasukazu; Umeno, Aya; Akazawa, Yoko; Shichiri, Mototada; Murotomi, Kazutoshi; Horie, Masanori

doi:10.5650/jos.ess14281

Cited by 39 publications

(20 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that the oxidation of fatty acids typically occurs in tissues submitted to oxidative stress, including sites of inflammation [ 23 , 24 ]. Indeed, in the present investigation, a number of the selected biomarkers were found to be potentially related to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Vaginal lipidomics of women with vulvovaginal candidiasis and cytolytic vaginosis: A non-targeted LC-MS pilot study

et al. 2018

View full text Add to dashboard Cite

ObjectiveTo characterize the lipid profile in vaginal discharge of women with vulvovaginal candidiasis, cytolytic vaginosis, or no vaginal infection or dysbiosis.DesignCross-sectional study.SettingGenital Infections Ambulatory, Department of Tocogynecology, University of Campinas, Campinas, São Paulo–Brazil.SampleTwenty-four women were included in this study: eight with vulvovaginal candidiasis, eight with cytolytic vaginosis and eight with no vaginal infections or dysbiosis (control group).MethodsThe lipid profile in vaginal discharge of the different study groups was determined by liquid chromatography-mass spectrometry and further analyzed with MetaboAnalyst 3.0 platform.Main outcome measuresVaginal lipids concentration and its correlation with vulvovaginal candidiasis and cytolytic vaginosis.ResultsPCA, PLS-DA and hierarchical clustering analyses indicated 38 potential lipid biomarkers for the different groups, correlating with oxidative stress, inflammation, apoptosis and integrity of the vaginal epithelial tissue. Among these, greater concentrations were found for Glycochenodeoxycholic acid-7-sulfate, O-adipoylcarnitine, 1-eicosyl-2-heptadecanoyl-glycero-3-phosphoserine, undecanoic acid, formyl dodecanoate and lipoic acid in the vulvovaginal candidiasis group; N–(tetradecanoyl)-sphinganine, DL-PPMP, 1-oleoyl-cyclic phosphatidic, palmitic acid and 5-aminopentanoic acid in the cytolytic vaginosis group; and 1-nonadecanoyl-glycero-3-phosphate, eicosadienoic acid, 1-stearoyl-cyclic-phosphatidic acid, 1-(9Z,12Z-heptadecadienoyl)-glycero-3-phosphate, formyl 9Z-tetradecenoate and 7Z,10Z-hexadecadienoic acid in the control group.ConclusionsLipids related to oxidative stress and apoptosis were found in higher concentrations in women with vulvovaginal candidiasis and cytolytic vaginosis, while lipids related to epithelial tissue integrity were more pronounced in the control group. Furthermore, in women with cytolytic vaginosis, we observed higher concentrations of lipids related to bacterial overgrowth.

show abstract

Section: Discussionmentioning

confidence: 99%

Vaginal lipidomics of women with vulvovaginal candidiasis and cytolytic vaginosis: A non-targeted LC-MS pilot study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Oxysterols are present in vivo in different forms, namely the esterified, sulfated, and conjugated forms, as well as free oxysterols [19]. We have recently presented LC-MS/MS and GC-MS methods for determining oxidation products of linoleates and cholesterol, respectively [20,21,22,23,24]. Briefly, physiological samples are mixed with saline solution and methanol containing the internal standards 8-iso-PGF2α-d4, 13-HODE-d4, and 7β-OHCh-d7.…”

Section: Evaluation Methods For Antioxidantsmentioning

confidence: 99%

Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones

et al. 2016

Self Cite

View full text Add to dashboard Cite

Many polyphenols that contain more than two phenolic hydroxyl groups are natural antioxidants and can provide health benefits to humans. These polyphenols include, for example, oleuropein, hydroxytyrosol, catechin, chlorogenic acids, hesperidin, nobiletin, and isoflavones. These have been studied widely because of their strong radical-scavenging and antioxidative effects. These effects may contribute to the prevention of diseases, such as diabetes. Insulin secretion, insulin resistance, and homeostasis are important factors in the onset of diabetes, a disease that is associated with dysfunction of pancreatic β-cells. Oxidative stress is thought to contribute to this dysfunction and the effects of antioxidants on the pathogenesis of diabetes have, therefore, been investigated. Here, we summarize the antioxidative effects of polyphenols from the perspective of their radical-scavenging activities as well as their effects on signal transduction pathways. We also describe the preventative effects of polyphenols on diabetes by referring to recent studies including those reported by us. Appropriate analytical approaches for evaluating antioxidants in studies on the prevention of diabetes are comprehensively reviewed.

show abstract

“…High levels of ROS and free radicals in erythrocytes can lead to damage of the antioxidant defense system. This leads to lipid peroxidation and increased cellular damage 11 .…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte Membrane Fatty Acid Composition in Premenopausal Patients with Iron Deficiency Anemia

et al. 2016

View full text Add to dashboard Cite

Chemistry of Lipid Peroxidation Products and Their Use as Biomarkers in Early Detection of Diseases

Cited by 39 publications

References 50 publications

Vaginal lipidomics of women with vulvovaginal candidiasis and cytolytic vaginosis: A non-targeted LC-MS pilot study

Vaginal lipidomics of women with vulvovaginal candidiasis and cytolytic vaginosis: A non-targeted LC-MS pilot study

Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones

Erythrocyte Membrane Fatty Acid Composition in Premenopausal Patients with Iron Deficiency Anemia

Contact Info

Product

Resources

About