Chemistry of Unprotected Amino Acids in Aqueous Solution: Direct Bromination of Aromatic Amino Acids with Bromoisocyanuric Acid Sodium Salt under Strong Acidic Condition.

Abstract

Acidic Condition. -Enantiopure brominated products such as (S)-(II), (S)-(III), (S)-(V) and (S)-(VI) are obtained without loss of optical activity. -(YOKOYAMA*, Y.; YAMAGUCHI, T.; SATO, M.; KOBAYASHI, E.; MURAKAMI, Y.; OKUNO, H.; Chem.

Detailed investigations into the Akabori–Momotani reaction for the synthesis of amphetamine type stimulants: Part 2

“…A c c e p t e d M a n u s c r i p t respectively [9,10]. However, the reports are a conference abstract only and no publication has appeared in literature.…”

Synthesis of Halogenated α‐Amino Acids

“…Direct monobromination of L-phenylalanine can be achieved using 1.1 equiv. bromoisocyanuric acid sodium salt (BICA-Na) in 60% sulfuric acid giving a mixture of o-and p-bromo-L-phenylalanines 88 and 89, which were separated by reverse-phase column chromatography (Scheme 10.21) [58].…”