Chemistry, pharmacology and analysis of Pseudostellaria heterophylla: a mini-review

Hu, De Jin; Shakerian, Farid; Zhao, Jing; Li, Shao‐Ping

doi:10.1186/s13020-019-0243-z

Cited by 31 publications

(21 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some drugs, like naldemedine and candidates from Super Natural II (SN00017653) and TCM (pseudostellarin C), have not been identified in previous studies as potential inhibitors of SARS-CoV-2 main protease and are suggested here for the first time. Interestingly, pseudostellarin C, which is a compound found in the roots of a traditional Chinese plant (Pseudostellaria heterophylla), is known medicinally for its application in dry cough arising from "lung dryness" (Hu et al, 2019). Naturally occurring compounds are a rich resource for drug innovation and development.…”

Section: Discussionmentioning

confidence: 99%

Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2

et al. 2020

View full text Add to dashboard Cite

The rapidly developing pandemic, known as coronavirus disease 2019 (COVID-19) and caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently spread across 213 countries and territories. This pandemic is a dire public health threat—particularly for those suffering from hypertension, cardiovascular diseases, pulmonary diseases, or diabetes; without approved treatments, it is likely to persist or recur. To facilitate the rapid discovery of inhibitors with clinical potential, we have applied ligand- and structure-based computational approaches to develop a virtual screening methodology that allows us to predict potential inhibitors. In this work, virtual screening was performed against two natural products databases, Super Natural II and Traditional Chinese Medicine. Additionally, we have used an integrated drug repurposing approach to computationally identify potential inhibitors of the main protease of SARS-CoV-2 in databases of drugs (both approved and withdrawn). Roughly 360,000 compounds were screened using various molecular fingerprints and molecular docking methods; of these, 80 docked compounds were evaluated in detail, and the 12 best hits from four datasets were further inspected via molecular dynamics simulations. Finally, toxicity and cytochrome inhibition profiles were computationally analyzed for the selected candidate compounds.

show abstract

Section: Discussionmentioning

confidence: 99%

Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The activity might be due to the increased macrophage phagocytosis capacity and NK cell activity and the enhancements in T and Th cells, as well as IL-2, IL-6 and IL-12 secretion and IgA, IgG1 and IgG2b production. Pseudostellaria heterophylla (P. heterophylla) is often used for children as a substitute for ginseng because of its mild effects [33]. P. heterophylla polysaccharides have been proved to benefit chronic fatigue syndrome, and the underlying mechanisms of action involve neuroendocrine and immune systems [34].…”

Section: Biological Activities Of Biomacromolecules Based On Its Effimentioning

confidence: 99%

Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review

et al. 2020

View full text Add to dashboard Cite

Biomacromolecules, the first components of bioactive substances in traditional Chinese medicines (TCM) have wide bioactivity-related efficacy but have not yet been fully appreciated compared to small molecule components. The present review brings a novel and systemic point of view to deepen the understanding of the pharmacodynamic material basis of TCM based on biomacromolecules (polysaccharides, proteins and nucleic acids). Biomacromolecules have been, are and will have considerable roles in the efficacy of Chinese medicine, as evidenced by the number of biological activities related to traditional clinical efficacy. The direct and indirect mechanisms of biomacromolecules are further accounted for in a variety of neurotransmitters, hormones, and immune substances to maintain immune function in both sensitive and stable equilibrium. The biological functions of biomacromolecules have been elaborated on in regard to their roles in the process of plant growth and development to the relationship between primary metabolism and secondary metabolism and to the indispensable role of polysaccharides, proteins, and nucleic acids in the quality formation of TCM. Understanding the functional properties and mechanisms of biological macromolecules will help to demystify the drug properties and health benefits of TCM.

show abstract

“…The substitution of Phe residue with Gly improves the water solubility of antamanide as well as the flexibility. The activity of antamanide derivatives was compared to that of pseudostellarin A ( PS-A ), a cyclic peptide isolated from Pseudostellaria heterophylla able to inhibit the tyrosinase activity [ 20 ]. A computational approach as molecular docking was used to understand at a molecular level the interactions occurring between the enzyme catalytic site and peptide inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Antamanide Analogs as Potential Inhibitors of Tyrosinase

Honisch¹,

Gazziero²,

Dallocchio³

et al. 2022

IJMS

View full text Add to dashboard Cite

The tyrosinase enzyme, which catalyzes the hydroxylation of monophenols and the oxidation of o-diphenols, is typically involved in the synthesis of the dark product melanin starting from the amino acid tyrosine. Contributing to the browning of plant and fruit tissues and to the hyperpigmentation of the skin, leading to melasma or age spots, the research of possible tyrosinase inhibitors has attracted much interest in agri-food, cosmetic, and medicinal industries. In this study, we analyzed the capability of antamanide, a mushroom bioactive cyclic decapeptide, and some of its glycine derivatives, compared to that of pseudostellarin A, a known tyrosinase inhibitor, to hinder tyrosinase activity by using a spectrophotometric method. Additionally, computational docking studies were performed in order to elucidate the interactions occurring with the tyrosinase catalytic site. Our results show that antamanide did not exert any inhibitory activity. On the contrary, the three glycine derivatives AG9, AG6, and AOG9, which differ from each other by the position of a glycine that substitutes phenylalanine in the parent molecule, improving water solubility and flexibility, showed tyrosinase inhibition by spectrophotometric assays. Analytical data were confirmed by computational studies.

show abstract

Chemistry, pharmacology and analysis of Pseudostellaria heterophylla: a mini-review

Cited by 31 publications

References 55 publications

Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2

Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2

Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review

Antamanide Analogs as Potential Inhibitors of Tyrosinase

Contact Info

Product

Resources

About