Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances

Li, Mengxia; Luo, Fangzhou; Tian, Xinyao; Yin, Shengyong; Zhou, Lin; Zheng, Shu-Sen

doi:10.3389/fonc.2020.595973

Cited by 13 publications

(11 citation statements)

References 98 publications

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“…In this study, we found that the expression of CMTM1 was higher in grade III glioma in the TCGA datasets. Previous studies indicated that CMTM2 is downregulated in liver cancer tissues, which is related to the outcome of liver cancer patients ( Li et al, 2020 ). However, no significant differences were found in the expression of various grades and genetic characteristics in LGG in our study.…”

Section: Discussionmentioning

confidence: 99%

CMTM Family Genes Affect Prognosis and Modulate Immunocytes Infiltration in Grade II/III Glioma Patients by Influencing the Tumor Immune Landscape and Activating Associated Immunosuppressing Pathways

Wang

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Lower-grade glioma (LGG) is one of the most common primary tumor types in adults. The chemokine-like factor (CKLF)-like Marvel transmembrane domain-containing (CMTM) family is widely expressed in the immune system and can modulate tumor progression. However, the role of the CMTM family in LGG remains unknown. A total of 508 LGG patients from The Cancer Genome Atlas (TCGA) database were used as a training cohort, and 155 LGG patients from the Chinese Glioma Genome Atlas (CGGA) array database, 142 LGG patients from the CGGA RNA-sequencing database, and 168 LGG patients from the GSE108474 database were used as the validation cohorts. Patients were subdivided into two groups using consensus clustering. The ENET algorithm was applied to build a scoring model based on the cluster model. Finally, ESTIMATE, CIBERSORT, and xCell algorithms were performed to define the tumor immune landscape. The expression levels of the CMTM family genes were associated with glioma grades and isocitrate dehydrogenase (IDH) status. Patients in cluster 2 and the high-risk score group exhibited a poor prognosis and were enriched with higher grade, wild-type IDH (IDH-WT), 1p19q non-codeletion, MGMT promoter unmethylation, and IDH-WT subtype. Patients in cluster 1 and low-risk score group were associated with high tumor purity and reduced immune cell infiltration. Enrichment pathways analysis indicated that several essential pathways involved in tumor progression were associated with the expression of CMTM family genes. Importantly, PD-1, PD-L1, and PD-L2 expression levels were increased in cluster 2 and high-risk groups. Therefore, the CMTM family contributes to LGG progression through modulating tumor immune landscape.

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Section: Discussionmentioning

confidence: 99%

CMTM Family Genes Affect Prognosis and Modulate Immunocytes Infiltration in Grade II/III Glioma Patients by Influencing the Tumor Immune Landscape and Activating Associated Immunosuppressing Pathways

Wang

Zhang

et al. 2022

Front. Cell Dev. Biol.

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“…Based on the Human Protein Atlas and bioinformatics analysis, a higher level of CMTM1 mRNA expression was associated with a lower survival probability in patients with HCC. 34 Although CMTM2 is not a prognostic index in HCC according to data from the Human Protein Atlas, several studies have revealed that CMTM2 expression is correlated with HCC pathological grades. 38 In addition, knockdown of CMTM2 promoted invasion and migration of HCC cells (Huh-7 and SMMC7721) by inducing the epithelial-mesenchymal transition (EMT) process.…”

Section: Cmtm Family Members In Digestive System Cancersmentioning

confidence: 99%

CMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review

Li¹,

Wang²,

Wang³

et al. 2022

CMAR

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“…While muscle specific ring finger protein 1-like, an E3 ubiquitin-protein ligase has been reported to be involved in proteasome-mediated degradation (74) which may be involved in degrading proteins originating from N. perurans in host defense. The inflammatory response to AGD is potentially dampened by the downregulated inflammatory mediated gene networks connected to the gene CKLF-like MARVEL transmembrane domain-containing protein 4 which exhibits similar expression in lung cancer, and matrix Gla protein which has been implicated in chronic inflammatory diseases as well as lung cancer (80)(81)(82). Two of the identified regulatory gene networks are associated with tissue repair including insulin-like growth factor 2b and catalase-like (77).…”

Section: Gene Candidates and Gene Network In Host Defense Against Agdmentioning

confidence: 99%

Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease

et al. 2021

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Marine farmed Atlantic salmon (Salmo salar) are susceptible to recurrent amoebic gill disease (AGD) caused by the ectoparasite Neoparamoeba perurans over the growout production cycle. The parasite elicits a highly localized response within the gill epithelium resulting in multifocal mucoid patches at the site of parasite attachment. This host-parasite response drives a complex immune reaction, which remains poorly understood. To generate a model for host-parasite interaction during pathogenesis of AGD in Atlantic salmon the local (gill) and systemic transcriptomic response in the host, and the parasite during AGD pathogenesis was explored. A dual RNA-seq approach together with differential gene expression and system-wide statistical analyses of gene and transcription factor networks was employed. A multi-tissue transcriptomic data set was generated from the gill (including both lesioned and non-lesioned tissue), head kidney and spleen tissues naïve and AGD-affected Atlantic salmon sourced from an in vivo AGD challenge trial. Differential gene expression of the salmon host indicates local and systemic upregulation of defense and immune responses. Two transcription factors, znfOZF-like and znf70-like, and their associated gene networks significantly altered with disease state. The majority of genes in these networks are candidates for mediators of the immune response, cellular proliferation and invasion. These include Aurora kinase B-like, rho guanine nucleotide exchange factor 25-like and protein NDNF-like inhibited. Analysis of the N. perurans transcriptome during AGD pathology compared to in vitro cultured N. perurans trophozoites, as a proxy for wild type trophozoites, identified multiple gene candidates for virulence and indicates a potential master regulatory gene system analogous to the two-component PhoP/Q system. Candidate genes identified are associated with invasion of host tissue, evasion of host defense mechanisms and formation of the mucoid lesion. We generated a novel model for host-parasite interaction during AGD pathogenesis through integration of host and parasite functional profiles. Collectively, this dual transcriptomic study provides novel molecular insights into the pathology of AGD and provides alternative theories for future research in a step towards improved management of AGD.

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Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances

Cited by 13 publications

References 98 publications

CMTM Family Genes Affect Prognosis and Modulate Immunocytes Infiltration in Grade II/III Glioma Patients by Influencing the Tumor Immune Landscape and Activating Associated Immunosuppressing Pathways

CMTM Family Genes Affect Prognosis and Modulate Immunocytes Infiltration in Grade II/III Glioma Patients by Influencing the Tumor Immune Landscape and Activating Associated Immunosuppressing Pathways

CMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review

Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease

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