Chemolytic Treatment of Patients with Urinary Tract Stones

Tiselius, Hans‐Göran

doi:10.1007/978-1-84800-362-0_52

Cited by 2 publications

(4 citation statements)

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“…First, although the widespread use of shockwave lithotripsy as the Wrst-choice treatment is accepted for a variety of urological clinics [3,8,12], we believe that joint shock wave action and chemolytic irrigation [4,6,7] should provide much more rapid removal of COM and especially, COM + COD stones from the human urinary tract. Second, for some patients, installation of nephrostomic catheters or stents into a kidney is required [6,12,14]. It gives additional possibility to destroy calcium oxalate concrements by irrigating the kidney interior with the chemolytic solutions proposed.…”

Section: Discussionmentioning

confidence: 99%

“…Abnormal biomineralization in the urinary tract aZicts patients worldwide [1][2][3][4][5][6][7][8]. From 3 to 14% of the population in Europe and the United States suVer from renal stones formation, most of which are composed of calcium oxalate hydrates [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Being attached to the epithelial tissue of a human kidney, such aggregates often pose signiWcant problems for modern little invasive removal techniques [3,[5][6][7]. Moreover, calcium oxalate renal stones are almost insoluble in well-established chemolytic solutions such as hemiacidrin or Suby G [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Chemolysis of calcium oxalate stones: study in vitro and possible clinical application

et al. 2011

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The flow cell modeling clinical conditions have been used to study the interaction between dilute chemolytic solutions and large calcium oxalate renal stones. The stone treatment with 5% disodium ethylenediaminetetraacetate aqueous solutions or citrate buffer are found not to provide notable disruption of the samples studied. The significant improvement is reached with the mixed compositions containing both natural and synthetic chelating reagents:citrate and ethylenediaminetetraacetate ions as well as an antibiotic. Description of the chemolytic irrigation, numerical results and their possible clinical application are the main topic of the present research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemolysis of calcium oxalate stones: study in vitro and possible clinical application

et al. 2011

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“…These 2 variables vary considerably during the 24-h period and the average levels tell extraordinarily little about specific risk periods [9]. Another important observation was that when 24-h or even 16-h urine was compared between normal subjects and stone-forming patients the overall differences were usually small [10‒12].…”

Section: Introductionmentioning

confidence: 99%

Composition of Urine Collected from Non-Stone-Forming Chinese Persons during Different Short-Term Periods of the Day

Chang

et al. 2021

Urol Int

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The purpose of this study in a small group of non-stone-forming Chinese persons was to measure the levels of supersaturation with calcium oxalate and calcium phosphate and pH with the aim of confirming if any of the different short-term urine samples were better for risk evaluation than a 24-h sample. Nine normal men and 1 woman collected urine during 4 periods of the day. Period 1 between 08 and 12 h, Period 2 between 12 and 18 h, Period 3 between 18 and 22 h, and Period 4 between 22 and 08 h. Each sample was analysed for calcium, oxalate, citrate, magnesium and phosphate, and estimates of supersaturation with calcium oxalate (CaOx) and calcium phosphate (CaP) were expressed in terms of AP(CaOx) and AP(CaP) index. An estimate of the solute load of CaOx was also calculated. Urine composition for 24-h urine (Period 24) was obtained mathematically from the analysed variables. Urine composition corresponding to 14-h urine portions 22–12 h (Period 14N) and 08–22 h (Period 14 D) were calculated. The lowest pH levels were recorded in Period 1 urine. The highest level of AP(CaOx) index was recorded during Period 1, and the product AP(CaOx) index × 107 × hydrogen ion concentration was significantly higher in Period 1 urine than in 24-h urine (p = 0.02). Also, the product SL(CaOx) × 107 × hydrogen ion concentration was significantly higher in Period 1 urine (p = 0.02). Low AP (CaP) index levels were recorded in Period 4, but also in all periods following dietary loads of calcium and phosphate. With the important reservation that the analytical results were obtained from non-stone-forming persons, the conclusion is that analysis of urine samples collected between 08 and 12 h might be an alternative to 24-h urine. The risk evaluation might advantageously be expressed either in terms of the product AP(CaOx) index × 107 × hydrogen ion concentration or the product SL(CaOx) × 107 × hydrogen ion concentration.

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Chemolytic Treatment of Patients with Urinary Tract Stones

Cited by 2 publications

References 33 publications

Chemolysis of calcium oxalate stones: study in vitro and possible clinical application

Chemolysis of calcium oxalate stones: study in vitro and possible clinical application

Composition of Urine Collected from Non-Stone-Forming Chinese Persons during Different Short-Term Periods of the Day

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