Chemoprevention and cytotoxic effect of Bauhinia variegata against N-nitrosodiethylamine induced liver tumors and human cancer cell lines

Balasubramanian, Ravikumar; Jayakar, B.; Murugesh, N; Sakthisekaran, Dhanapal

doi:10.1016/j.jep.2005.08.074

Cited by 59 publications

(39 citation statements)

References 19 publications

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“…activities. [8][9][10][11] The present investigation is aimed at studying the immunomodulatory activity of the ethanolic extract of the stem bark of Bauhinia variegata Linn, in order to justify the traditional claims endowed upon this herbal drug as a rasayana.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the immunomodulatory activity of ethanolic extract of the stem bark ofBauhinia variegataLinn

Ghaisas¹,

Shaikh²,

Deshpande³

2009

Int J Green Pharm

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Section: Introductionmentioning

confidence: 99%

Evaluation of the immunomodulatory activity of ethanolic extract of the stem bark ofBauhinia variegataLinn

Ghaisas¹,

Shaikh²,

Deshpande³

2009

Int J Green Pharm

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“…Estudos realizados com extratos etanólicos de B. variegata revelam atividade quimiopreventiva e efeitos citotóxicos sobre tumores de fígado de rato e linhagens celulares cancerígenas humanas (Rajkapoor et al 2006). Contudo, é importante salientar que tal estudo foi realizado sobre amostras de B. variegata coletadas em Salem, Índia, onde a espécie é nativa e, portanto, está sob condições diferentes das brasileiras, podendo variar sua composição fitoquímica.…”

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Análise morfoanatômica comparativa da folha de Bauhinia forficata Link e B. variegata Linn. (Leguminosae, Caesalpinioideae)

Lusa

Bona

2009

Acta Bot. Bras.

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RESUMO -(Análise morfoanatômica comparativa da folha de Bauhinia forficata Link e B. variegata Linn. (Leguminosae, Caesalpinioideae)). Esse trabalho foi desenvolvido com o propósito de subsidiar o controle de qualidade das espécies medicinais Bauhinia forficata Link e B. variegata Linn. Essas foram coletadas em jardins e terrenos baldios de Curitiba, Paraná, Brasil. As amostras do limbo, pecíolo e pulvino foram fixadas em F.A.A. 50 e conservadas em etanol 70%. O seccionamento do material foi feito em micrótomo de rotação (material incluído em historresina) ou a mão livre e as lâminas foram montadas de forma permanente ou semipermanente. Foram realizadas análises em microscopia fotônica e eletrônica de varredura. A folha de B. forficata é alongada, com folíolos unidos em torno da metade do limbo, ápices agudos, superfície adaxial lisa e mucro entre os folíolos. Enquanto que, B. variegata possui folha mais larga que longa, com folíolos unidos na porção terminal do limbo e ápices obtusos. Nos pulvinos de B. variegata ocorrem camadas de colênquima, ausentes em B. forficata. O formato e a bainha de fibras dos pecíolos, em secção transversal, são distintos entre as espécies, assim como a distribuição dos estômatos e tricomas no limbo e a forma do bordo em secção transversal. B. variegata possui maior quantidade de idioblastos com drusas e compostos fenólicos. As características morfológicas e anatômicas de B. forficata e B. variegata contribuem para a identificação e diferenciação das espécies, sendo importantes para o controle de qualidade do material destinado à pesquisa e à indústria farmacêutica. Palavras-chave: Bauhinia, pata-de-vaca, plantas medicinais ABSTRACT -(Comparative morphogical and anatomycal analyses of Bauhinia forficata Link and B. variegata Linn. (Leguminosae, Caesalpinioideae) leaves). This work has been developed with the purpose of helping the quality control of the medicinal speciesBauhinia forficata Link and B. variegata Linn., which were collected in gardens and vacant lots in Curitiba, Paraná, Brazil. The samples of leaf blade, petiole and pulvinus were fixed in FAA 50 and preserved in alcohol 70. The sectioning of the material was made in rotational microtome (with the material included in historesine) or manually and the blades were mounted in permanent or semipermanent way. Analyses in photonic and scanning electronic microscopy were performed. The leaf of B. forficata is elongated, with the leaflets united around the middle of the leaf blade, acute apices, smooth adaxial surface and mucros between the leaflets. The B. variegata, on the other hand, possesses a broader than long leaf, with the leaflets united in the terminal portion of the blade and obtuse apices. In the pulvinus of B. variegata there are collenchyma layers, which are absent in B. forficata. The shape and the petiole fibers sheath, in cross section, are distinct in both species, as well as the distribution of the stomata and trichomes in the leaf blade and the shape of the border in transversal section. B. variegata possess...

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“…There are also a few reports of antitumor activity of B. variegata ethanolic extract against Dalton's ascetic lymphoma (DAL) in Swiss albino mice [42] and N-nitrosodiethylamine induced experimental liver tumors in rats and human cancer cell lines [43]. The present study evaluates the chemopreventive effect of the different parts and different doses of B. variegata on B16F10 melanoma tumor on C57BL mice.…”

Section: Introductionmentioning

confidence: 97%

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

Pandey

2017

Appl Cancer Res

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Background: Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since life on earth; more than 50% of existing cancer treatments is derived from plants. Bauhinia variegata is well-known medicinal plant used from the ancient era to till date for their medicinal values. Scientific literatures have not documented any evidence of the antitumour potential of Bauhinia variegata against B16F10 melanoma tumor model in C57BL mice. The present investigation was undertaken to explore the antitumour activity of Leaf, stem bark and flower extract of Bauhinia variegata against B16F10 melanoma tumour model in C57BL mice. Methods: Hydro-methanolic extract prepared from the leaf, stem bark and flower of Bauhinia variegata were assessed for their antitumor activity. The extracts at doses of 500 and 750 mg/kg b.wt. were given orally along with cyclophosphamide (chemotherapeutic drug) for 40 days for exploring antitumor activity against melanoma tumor (B16F10) in C57BL mice. Inhibition of tumor growth, increase in survival time of animal with treatment, histopathological studies and antioxidant parameter were determined. Results: The Present investigation showed significant effect of the B. variegata L. in preventing melanoma tumor by B16F10 cell line in C57BL/6 mice. As compared with the tumour control group, the remarkable results especially in the group which received B. variegata extract and cyclophosphamide together were obtained for all of the measured parameters. Dose dependent response was observed in tumor volume, inhibition rate, life span time and antioxidant parameter of extracts. Combination treatment of cyclophosphamide and B. variegata extracts showed more pronounced effect. Conclusions: These findings suggest that B. variegata hydromethanolic extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.

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Chemoprevention and cytotoxic effect of Bauhinia variegata against N-nitrosodiethylamine induced liver tumors and human cancer cell lines

Cited by 59 publications

References 19 publications

Evaluation of the immunomodulatory activity of ethanolic extract of the stem bark ofBauhinia variegataLinn

Evaluation of the immunomodulatory activity of ethanolic extract of the stem bark ofBauhinia variegataLinn

Análise morfoanatômica comparativa da folha de Bauhinia forficata Link e B. variegata Linn. (Leguminosae, Caesalpinioideae)

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

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