Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?

Siemianowicz, Krzysztof; Likus, Wirginia; Dorecka, Mariola; Wilk, Renata; Dziubdziela, Włodzimierz; Markowski, Jarosław

doi:10.1155/2018/9051854

Cited by 14 publications

(10 citation statements)

References 112 publications

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“…[ 34 ] Previous studies also showed elevated levels of TBARS, LHPO, and CD within the circulation of oral cancer‐bearing animals. [ 35 ] The oral administration of Vicenin‐2 drastically reduced the degree of plasma and buccal mucosa membrane TBARS in DMBA‐brushed OSCC hamsters, which indicates that Vicenin‐2 has an anti‐lipid peroxidative capability against buccal carcinogenesis. Both the enzymatic/nonenzymatic antioxidants play imperative roles in ROS‐arbitrated oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Anticancer activity of Vicenin‐2 against 7,12 dimethylbenz[a]anthracene‐induced buccal pouch carcinoma in hamsters

Zheng

Wang³

2020

J Biochem & Molecular Tox

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Buccal mucosa carcinoma is a significant cause of death in developing nations. Vicenin‐2 is a significant bioactive compound found in Ocimum sanctum Linn or Tulsi that possesses several pharmacologic properties. Our focus is to understand the possible impact of Vicenin‐2 on 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced oral carcinogenesis in hamsters. Buccal carcinoma was induced by treatment with carcinogenic DMBA, three times a week for 14 weeks. We determined 100% tumor incidence, abnormal tumor volume, inclined tumor burden, and deduced body weight in DMBA‐induced oral squamous cell carcinoma (OSCC) hamsters. The upregulation of cytokine levels (interleukin [IL]‐6, IL‐1β, and tumor necrosis factor‐alpha [TNF‐α]) was observed in DMBA‐induced OSCC hamsters. Moreover, dysplastic, hyperplastic, and squamous cell carcinoma was identified in the DMBA‐induced OSCC hamsters. The diminished activities of lipid peroxidation and enzymatic/nonenzymatic antioxidants were observed in DMBA‐induced hamsters. Furthermore, the high expression of proliferating cell nuclear antigen (PCNA), Cyclin‐D1, and Bcl‐2, and attenuated Bax expression were observed in DMBA‐induced hamsters. Our study results explored that Vicenin‐2 (30 mg/kg) treated with DMBA‐brushed hamsters averted tumor incidence, improved the antioxidant status, and inhibited lipid peroxidation. Moreover, Vicenin‐2 inhibited the immunohistochemical expression of PCNA, Cyclin‐D1, and Bcl‐2, and significantly restored apoptotic Bax levels. The Vicenin‐2 treatment prevents the lesion formation in the oral epithelium of the DMBA‐induced hamsters. The Vicenin‐2 treatment potentially halts the proinflammatory cytokines (IL‐6, IL‐1β, and TNF‐α) production in OSCC hamsters. Thus, we proved that Vicenin‐2 prevents DMBA‐induced buccal carcinogenesis in hamsters via improving antioxidants by modulating apoptotic and cytokines signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Anticancer activity of Vicenin‐2 against 7,12 dimethylbenz[a]anthracene‐induced buccal pouch carcinoma in hamsters

Zheng

Wang³

2020

J Biochem & Molecular Tox

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“…Green tea (camellia sinensis) contains various cancer preventive catechins which are epigallocatechin gallate (EGCG), epigallocatechin (EGC) and epicatechin gallate (ECG). It was found that drinking over 10 cups (120 mL/cup) of green tea per day could prevent cancer recurrence in various organs in humans (12,13). In 1987, the cancer preventive activity of EGCG was first reported (14), and since then, the significance of EGCG and green tea in cancer prevention and treatment has become widely recognized (15).…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive Effect of Green Tea and Curcumin in Induced Oral Squamous Cell Carcinoma: An Experimental Study

Saleh

Darwish

Nouaem

et al. 2020

Alexandria Dental Journal

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INTRODUCTION: Oral squamous cell carcinoma (OSCC) has the highest mortality rates among all carcinomas and is the most common head and neck cancer. Several natural compounds and micronutrients have been under investigation for their efficacy in head and neck cancer chemoprevention. Green tea contains various cancer preventive catechins that have a role in preventing cancer recurrence in various organs in humans. Curcumin, a natural polyphenol, is one of the most investigated biomolecules from Mother Nature. Curcumin has been shown to exert significant growth inhibitory effect on oral precancerous and carcinoma cell lines, and the effect is synergistic with epigallocatechin gallate, the most abundant polyphenol in tea. OBJECTIVES: To assess the chemopreventive effects of green tea and curcumin through induction of hamster buccal pouch carcinoma by using an apoptotic marker and compare their effect each alone and in combination. MATERIALS AND METHODS: Squamous cell carcinoma was chemically induced in fifty Syrian golden hamsters divided into 5 groups (10 each). The first group was used as normal control group. The second group received the carcinogenic agent only. The other three groups received green tea, curcumin and combination of both, respectively. RESULTS: Normal control group (A) revealed neither pathological nor inflammatory changes in the buccal pouch with 1.72% of the cells underwent apoptosis while the cells of positive control group (B) resulted in 11.57% apoptosis. In the study groups, treatment of the cells with green tea (C), curcumin (D) and both of them (E) resulted in 82.22 %, 78.91%, 96.63% apoptosis respectively. The fluorescent image by confocal laser scanning in group B showed increase of the red fluorescence in the nucleus and cytoplasm of the squamous cell carcinoma cells indicating high proliferating cells while the fluorescent image of group C, D and E showed decrease of the red florescence in the nuclei of the squamous cell carcinoma cells indicating low proliferation. CONCLUSIONS: Green tea and curcumin have a significant chemopreventive effect against oral carcinogenesis and the combination of both agents has a better effect.

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“…Physiologic doses of retinoids also stimulate killer T-cell production and cell-mediated cytotoxicity, which may be crucial in the treatment of cancer. [ 14 15 ] The teratogenic action of retinoids has been the most serious adverse effect. [ 16 ] Vitamin C: Vitamin C is the most prevalent antioxidant component of fruits and vegetables, which could exert chemopreventive effects and can prevent oxidative stress–mediated chronic diseases without apparent toxicity at doses higher than the current recommended dietary allowance of 100–120mg/day for adults.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

Section: Aterials and M Ethodsmentioning

confidence: 99%

Chemopreventive agents in oral premalignancy: A medical management review

Suvarna

Chaitanya

Ameer

et al. 2020

J Int Soc Prevent Communit Dent

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A BSTRACT Aims and Objective: The term chemoprevention denotes the use of specific natural or synthetic chemical agents to prevent carcinogenesis. Chemoprevention may help delay the process of carcinogen activation and prevent the conversion of preneoplastic cells. These agents play an active role in the secondary level of prevention and reduce malignancy-associated morbidity and mortality. A new term, “prophylactic antioxidant therapy,” was coined and proposed. This review has assessed all major chemopreventive agents used for oral premalignancy and malignant conditions, which will reduce the economic burden on the patients. Materials and Methods: A systematic literature search was performed using PubMed, Medline, Embase, Cochrane Library, and EBSCO search, with language restriction to English. The search incorporated published literature from 1990 to 2018 using the medical subject heading terms. Literature search was performed using the following keywords: Chemoprevention, Premalignancy, and Oral Malignancy. Results: Of 99 publications related to the search strategy, 45 full articles relevant to the chemopreventive agents in premalignacy and oral malignancy were acquired for further inspection. Of the 45 articles, 30 met the inclusion criteria. Data were collected, and a brief summary of the studies regarding different chemopreventive agents that were most commonly used in oral premalignancy and malignancies was written. Conclusion: This review suggests administration of major chemopreventive agents for superior prognosis in individuals with an elevated risk of premalignancy and malignancy.

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Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?

Cited by 14 publications

References 112 publications

Anticancer activity of Vicenin‐2 against 7,12 dimethylbenz[a]anthracene‐induced buccal pouch carcinoma in hamsters

Anticancer activity of Vicenin‐2 against 7,12 dimethylbenz[a]anthracene‐induced buccal pouch carcinoma in hamsters

Chemopreventive Effect of Green Tea and Curcumin in Induced Oral Squamous Cell Carcinoma: An Experimental Study

Chemopreventive agents in oral premalignancy: A medical management review

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