Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disorder directed against antigens secreted by the basal cell layer, with an incidence of 0.02-0.22% in Indian population and showing female predilection. Stress is considered one of the etiological factors in the causation, progression, and recurrence of this disease. To evaluate the levels of serum cortisol, anxiety, and depression in patients with symptomatic OLP and to correlate the levels of serum cortisol with anxiety and depression. Sixty subjects were categorized into two groups. Group A: 30 adults with no history of OLP and no psychological history of anxiety and depression. Group B: 30 patients with clinically and histopathologically diagnosed symptomatic OLP. The subjects in both groups were evaluated for anxiety and depression levels using the Hospital Anxiety and Depression Scale (HADS) questionnaire and serum cortisol levels (8-9 am sample) using the chemiluminiscence method. Higher Serological and psychological assessment of patients with OLP
Background: Lichen planus is a T-cell-mediated autoimmune disease, in which CD8+ T-cells releases the cytokines such as tumor necrosis factor-alpha and interleukin-12 disrupting basement membrane integrity. Treatment modalities were directed toward the relief in signs and symptoms and preventing recurrences. Zinc activates caspase-3 and DNA fragmentation, resulting in the apoptosis of keratinocytes. Prevention of matrix metalloproteinases1 (MMP1) activation, inhibits the Tcell accumulation in oral lichen planus (OLP) and by inhibiting MMP9, prevents the cleavage of collagen resulting in maintaining the integrity of the basement membrane. Objectives: The main objective of the study is to compare the efficacy of oral zinc 50 mg and 0.1% triamcinolone Orabase with 0.1% triamcinolone Orabase alone on the healing process of symptomatic OLP. Materials and Methods: A total of forty participants were randomly categorized into two groups: Group A and Group B with 20 patients with OLP and having symptoms of burning sensation. Group A patients had received 0.1% triamcinolone Orabase twice daily application. Group B patients had provided with oral zinc 50 mg and 0.1% triamcinolone Orabase twice daily for 8 weeks. The follow-up period for both the groups was 6 months. Lesional size was measured by Thongprasom scale and burning sensation was assessed by visual analog scale at each visit till the cessation of treatment. Results: There was decrease in the burning sensation and lesional size from the first visit to follow-up period which was statistically significant in both groups (P = 0.000). Conclusion: Oral zinc therapy was adjunctive in reducing the burning sensation and lesional size in the symptomatic OLP.
A BSTRACT Aims and Objective: The term chemoprevention denotes the use of specific natural or synthetic chemical agents to prevent carcinogenesis. Chemoprevention may help delay the process of carcinogen activation and prevent the conversion of preneoplastic cells. These agents play an active role in the secondary level of prevention and reduce malignancy-associated morbidity and mortality. A new term, “prophylactic antioxidant therapy,” was coined and proposed. This review has assessed all major chemopreventive agents used for oral premalignancy and malignant conditions, which will reduce the economic burden on the patients. Materials and Methods: A systematic literature search was performed using PubMed, Medline, Embase, Cochrane Library, and EBSCO search, with language restriction to English. The search incorporated published literature from 1990 to 2018 using the medical subject heading terms. Literature search was performed using the following keywords: Chemoprevention, Premalignancy, and Oral Malignancy. Results: Of 99 publications related to the search strategy, 45 full articles relevant to the chemopreventive agents in premalignacy and oral malignancy were acquired for further inspection. Of the 45 articles, 30 met the inclusion criteria. Data were collected, and a brief summary of the studies regarding different chemopreventive agents that were most commonly used in oral premalignancy and malignancies was written. Conclusion: This review suggests administration of major chemopreventive agents for superior prognosis in individuals with an elevated risk of premalignancy and malignancy.
Background: Data show that the prevalence of depression, anxiety, and stress is more among medical students compared to general population and thus proving that the community of the medical students is a vulnerable group or high-risk group, where we need to take adequate measures to counter this issue among this particular community. Objective: The objective of the study was to study the prevalence of depression, anxiety, and stress among one of the private Medical college students. Materials and Methods: An institution-based cross-sectional study was conducted in a private medical college among 450 medical students of 1st, 2nd, 3rd, and 4th year and interns and postgraduate (PG) students for 6 months. “Depression Anxiety Stress Scale 21” which was already validated and standardized was used for the present study. “The internal consistency, i.e., Cronbach's alpha value was 0.87 that was suggestive of high reliability.” Data collection was done in batches for undergraduates and for interns and PGs, whenever they were free and available. Anonymity was maintained. Results: Prevalence of depression, anxiety, and stress among medical students was 58.2%, 68.7%, and 35.3%, respectively. The most common was moderate grade of depression (30.7%), severe anxiety (39.6%), and moderate stress (15.8%). After testing for associated factors with depression, anxiety, and stress, it was fond that only belonging to joint family type and being undergraduate were found to be significantly associated with high levels of stress (P < 0.05). Conclusion: Prevalence of depression, anxiety, and stress among medical students was very high in this medical college. These results cannot be generalized to other medical students of other medical colleges but definitely reflect that medical students are depressed, anxious, and stressed.
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