Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review

Coêlho, Maria do Perpetuo Socorro de Sousa; Pereira, Irislene Costa; Oliveira, Kynnara Gabriella Feitosa de; Oliveira, Iara Katryne Fonseca; Rizzo, Márcia dos Santos; Oliveira, Victor Alves de; Silva, Felipe Cavalcanti Carneiro da; Torres–Leal, Francisco Leonardo; Sousa, João Marcelo de Castro e

doi:10.1016/j.clnesp.2022.11.001

Cited by 11 publications

(4 citation statements)

References 116 publications

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“…Previous metabolomic studies of different cancers having a focus on vitamin E are limited. Regarding the biological insights into vitamin E biochemical effects (including sex steroids) relevant to cancers, the delta-tocopherol vitamers significant in our study showed antitumor and adjuvant chemopreventive potential in breast cancer cells [ 13 ]. Although prospective studies in healthy women have consistently shown a strong relationship between high serum androgen levels and increased risk of developing ER-positive breast cancers [ 27 , 28 ], the link between androgen receptor (AR) positivity and improved outcomes in ER-positive tumors has revealed the beneficial effect of androgens [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…A strong correlation was also observed between the changes in androgenic steroid metabolites and the vitamin E supplement-associated reduction in C 22 lactone sulfate in the 400 IU/day RCT only. As for the other cancer sites, in vitro studies and animal models of breast cancer supplemented with tocopherol or tocotrienol vitamers showed antitumor and chemo-preventive activity [ 13 ], and inverse associations have been observed between vitamin E consumption and risk of bladder and esophageal cancer [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Metabolomic Analysis of Vitamin E Supplement Use in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

et al. 2023

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The effects of vitamin E supplementation on cancer and other chronic diseases are not clear. We compared the serum metabolomic profile of differing vitamin E dosages in order to re-examine the previously observed changes in a novel C22 lactone sulfate compound, androgenic steroids, and other metabolites. A total of 3409 women and men previously selected for metabolomics studies in the PLCO Cancer Screening Trial were included in this investigation. Serum metabolites were profiled using ultrahigh-performance liquid and gas chromatography/tandem mass spectrometry. Seventy known metabolites including C22 lactone sulfate and androgens were significantly associated with vitamin E supplementation. In the sex-stratified analysis, 10 cofactors and vitamins (e.g., alpha-CEHC sulfate and alpha-CEHC glucuronide), two carbohydrates (glyceric and oxalic acids), and one lipid (glycocholenate sulfate) were significantly associated with vitamin E dose in both males and females (FDR-adjusted p-value < 0.01). However, the inverse association between C22 lactone sulfate and daily vitamin E supplementation was evident in females only, as were two androgenic steroids, 5-androstenediol and androsterone glucuronide. Our study provides evidence of distinct steroid hormone pathway responses based on vitamin E dosages. Further studies are needed to gain biological insights into vitamin E biochemical effects relevant to cancer and other chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolomic Analysis of Vitamin E Supplement Use in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

et al. 2023

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“…The homologue α-tocopherol is found most predominantly in human tissue and appears to be preferentially absorbed and metabolized. Despite this, all forms of vitamin E share the same antioxidant mechanism, which acts by scavenging for free lipid peroxyl radicals that are biproducts of the lipid peroxidation chain reaction—particularly protecting the lipid membranes of the cell, where vitamin E is often found [ 40 , 118 , 119 , 120 ].…”

Section: Vitamin Ementioning

confidence: 99%

Antioxidant and Anti-Tumor Effects of Dietary Vitamins A, C, and E

et al. 2023

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Oxidative stress, a condition characterized by an imbalance between pro-oxidant molecules and antioxidant defense systems, is increasingly recognized as a key contributor to cancer development. This is because the reactive oxygen species (ROS) generated during oxidative stress can damage DNA, proteins, and lipids to facilitate mutations and other cellular changes that promote cancer growth. Antioxidant supplementation is a potential strategy for decreasing cancer incidence; by reducing oxidative stress, DNA damage and other deleterious cellular changes may be attenuated. Several clinical trials have been conducted to investigate the role of antioxidant supplements in cancer prevention. Some studies have found that antioxidant supplements, such as vitamin A, vitamin C, and vitamin E, can reduce the risk of certain types of cancer. On the other hand, some studies posit an increased risk of cancer with antioxidant supplement use. In this review, we will provide an overview of the current understanding of the role of oxidative stress in cancer formation, as well as the potential benefits of antioxidant supplementation in cancer prevention. Additionally, we will discuss both preclinical and clinical studies highlighting the potentials and limitations of preventive antioxidant strategies.

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“…Until now, there has been in vivo and in vitro data on prevention for each of the various cancer subtypes, especially breast cancer. The anticancer effect of tocopherol has been studied for several decades, and the results may be summarized as follows: (1) reduction of estrogen receptor; (2) expression of the PPARγ (peroxisome proliferator receptor γ); (3) activation of apoptosis; (4) anti-inflammatory and antioxidant properties, and (5) enhancement of Nrf2 activity (Das Gupta et al 2015;Gupta and Suh 2016;Bak et al 2018;Coelho et al 2023). In summary, the expression of γtocopherol in several potential medicinal plants has been presented (Table 2).…”

Section: Tocopherol-coding γ-Tmt Genementioning

confidence: 99%

Understanding of genes encoding bioactive compounds from potential medicinal plants in Indonesia as cancer cell inhibitors

MUFLIKHATI,

SIANIPAR,

SYAMSUNARNO

et al. 2023

Biodiversitas

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Abstract. Muflikhati Z, Sianipar NF, Syamsunarno MRAA, Anas. 2023. Understanding of genes encoding bioactive compounds from potential medicinal plants in indonesia as cancer cell inhibitors. Biodiversitas 24: 4645-4660. Indonesia has abundant plant diversity and enormous potential to be developed as a source of medicinal plants due to the content of bioactive chemicals in them. Potential medicinal plants from Indonesia, such as Andrographis paniculata (Sambiloto), Curcuma longa (Kunyit), Moringa oleifera (Moringa), Phyllanthus niruri (Meniran), Orthosiphon stamineus (Kumis kucing), Typhonium flagelliforme (Keladi tikus), and Zingiber officinale (Jahe), contain bioactive compounds with mechanisms that act as anticancer. Bioactive compounds with anticancer mechanisms in plants can be controlled by specific genes. Therefore, it is important to elaborate on bioactive compounds and the genes involved. This article aims to discuss the genes encoding bioactive compounds in Indonesian medicinal plants and the mechanisms that can inhibit cancer cell growth. Several genes encode anticancer compounds, such as lectin-coding genes, the stigmasterol-coding CYP710A gene, the tocopherol-coding ?-TMT gene, the fatty acid-coding FAD gene, the doxorubicin-coding DXR gene, and the chalcone synthase-coding CHS gene. These genes have mechanisms to increase the expression of several apoptosis-promoting proteins, including BCL-2 family members, in several cancer cell models. This article also describes the potential utilization and creation of molecular markers linked to genes encoding anticancer chemicals and can be used as a reference for research on medicinal plants that is still limited. Knowledge of genes encoding anticancer compounds in plants can support future research in the development of cancer drugs.

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Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review

Cited by 11 publications

References 116 publications

Metabolomic Analysis of Vitamin E Supplement Use in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Metabolomic Analysis of Vitamin E Supplement Use in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Antioxidant and Anti-Tumor Effects of Dietary Vitamins A, C, and E

Understanding of genes encoding bioactive compounds from potential medicinal plants in Indonesia as cancer cell inhibitors

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