Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model

Sharmila, Govindaraj; Bhat, Firdous Ahmad; Arunkumar, Ramesh; Elumalai, Perumal; Singh, Pratibha; Kalimuthu, S; Arunakaran, J.

doi:10.1016/j.clnu.2013.08.011

Cited by 130 publications

(84 citation statements)

References 27 publications

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“…Numerous previous studies have failed to find a relationship between vitamin D levels and overall prostate cancer risk in the general population . However, three studies found evidence of a relationship between vitamin D deficiency and aggressive prostate cancer in the general population .…”

Section: Discussionmentioning

confidence: 97%

Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum vitamin D status

et al. 2015

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Background African American (AA) men experience higher rates of prostate cancer (PCa) and vitamin D (vitD) deficiency than white men. VitD is promoted for PCa prevention, but there is conflicting data on the association between vitD and PCa. We examined the association between serum vitD and dietary quercetin and their interaction with PCa risk in AA men. Methods Participants included 90 AA men with PCa undergoing treatment at Howard University Hospital (HUH) and 62 controls participating in HUH’s free PCa screening program. We measured serum 25-hydroxy vitD [25(OH)D] and used the 98.2 item Block Brief 2000 Food Frequency Questionnaires to measure dietary intake of quercetin and other nutrients. Case and control groups were compared using two-sample t test for continuous risk factors and Fisher exact test for categorical factors. Associations between risk factors and PCa risk were examined via age-adjusted logistic regression models. Results Interaction effects of dietary quercetin and serum vitD on PCa status were observed. AA men (age 40–70) with normal levels of serum vitD (> 30 ng/ml) had a 71% lower risk of PCa compared to AA men with vitD deficiency (OR=0.29, 95% CI: 0.08–1.03; p=0.055). In individuals with vitD deficiency, increased dietary quercetin showed a tendency toward lower risk of PCa (OR=0.91, 95% CI: 0.82–1.00; p=0.054, age-adjusted) while men with normal vitD were at elevated risk (OR=1.23, 95% CI: 1.04–1.45). Conclusions These findings suggest that AA men who are at a higher risk of PCa may benefit more from vitD intake, and supplementation with dietary quercetin may increase the risk of PCa in AA men with normal vitD levels. Further studies with larger populations are needed to better understand the impact of the interaction between sera vitD levels and supplementation with quercetin on PCa in AA men.

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Section: Discussionmentioning

confidence: 97%

Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum vitamin D status

et al. 2015

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“…Besides, dietary quercetin (200 mg/kg body weight thrice a week) protected against prostate carcinogenesis induced by hormone (testosterone) and carcinogen ( N -methyl- N -nitrosourea) in rats [104]. In another preclinical rat model of prostate cancer, oral administration of quercetin (200 mg/kg/day) prevented cancer development by down-regulating the cell survival, proliferative and anti-apoptotic proteins [105]. In HeLa cervical cancer cells, quercetin treatment (110.38 ± 0.66 μM) led to ROS accumulation to induce apoptosis and G 2 /M cell cycle arrest [106].…”

Section: Experimental Studiesmentioning

confidence: 99%

Natural Polyphenols for Prevention and Treatment of Cancer

et al. 2016

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There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.

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“…Studies proved that quercetin is able to enhance radiotherapy and chemotherapy in animal models [1112]. Besides, quercetin is also a chemopreventive agent against diseases including tumors [13]. Recently, rising evidences elucidated that anti-cancer activity of quercetin is via growth inhibition and proapoptosis in many cancer cells models [14151617].…”

Section: Introductionmentioning

confidence: 99%

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

Nguyen

Lee

Sharma

et al. 2017

Korean J Physiol Pharmacol

139

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Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell cycle progression. Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities. We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a. Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest. In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity. Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin. Taken together, our study suggests that quercetin induces apoptosis and cell cycle arrest via modification of Foxo3a signaling in triple-negative breast cancer cells.

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Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model

Cited by 130 publications

References 27 publications

Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum vitamin D status

Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum vitamin D status

Natural Polyphenols for Prevention and Treatment of Cancer

Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity

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