Chemoreflex control of the cardiovascular system remains altered after recovery from low protein diet early in life

Sá, Renato Willian Martins; Borges, Gabriel Silva Marques; Chianca, Deoclécio A.; Oliveira, Lisandra Brandino de; Cardoso, Leonardo Máximo

doi:10.1016/j.autneu.2014.06.008

Cited by 2 publications

(13 citation statements)

References 16 publications

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“…In our previous study, rats recovered from a more severe low‐protein (6%) diet after weaning had increased BRS (Sá et al . ), and this is consistent with the idea that severe protein restriction may produce irreversible changes in baroreflex sensitivity. As shown in a previous study, activation of the baroreflex by bolus injection of phenylephrine also elicited large bradycardic responses in protein‐restricted (6%) rats (Loss et al .…”

Section: Discussionsupporting

confidence: 90%

“…In contrast, that was not the case of our previous study, which followed the same protocol but used 6% protein in the diet instead of 8% (Sá et al . ). This discrepancy may suggest that rats fed 8% protein had different compensatory rearrangements in their metabolisms to deal with a less severe protein restriction.…”

Section: Discussionmentioning

confidence: 97%

“…In addition, it was demonstrated recently that a food recovery protocol applied during the 70 days after the same malnutrition protocol (6% protein diet) was not capable of restoring the chemoreflex responsiveness back to normal (Sá et al . ). Current data are in agreement with these observations, especially because we demonstrated that pressor and bradycardic responses to chemoreflex activation were high in R‐PR rats.…”

Section: Discussionmentioning

confidence: 97%

“…() and reported by us previously (Sá et al . ). Cardiovascular data analyses were carried out at baseline (before losartan) and 15 min after losartan injection.…”

Section: Methodsmentioning

confidence: 97%

“…Additionally, recent study also revealed that Fischer rats, when recovered on a normal protein diet for 70 days, still exhibited increased pressor responses to chemoreflex activation (Sá et al . ).…”

Section: Introductionmentioning

confidence: 97%

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Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT₁ receptors

Sá

Haibara

Gomes

et al. 2016

Experimental Physiology

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Edited by: Jian Wang New Findings r What is the central question of this study?In this study, we sought to investigate whether cardiovascular responses to peripheral chemoreflex activation of rats recovered from protein restriction are related to activation of AT 1 receptors. r What is the main finding and its importance?This study highlights the fact that angiotensinergic mechanisms activated by AT 1 receptors do not support increased responses to peripheral chemoreflex activation by KCN in rats recovered from protein restriction. Also, we found that protein restriction led to increased resting ventilation in adult rats, even after recovery.The effects of a low-protein diet followed by recovery on cardiorespiratory responses to peripheral chemoreflex activation were tested before and after systemic angiotensin II type 1 (AT 1 ) receptor antagonism. Male Fischer rats were divided into control and recovered (R-PR) groups after weaning. The R-PR rats were fed a low-protein (8%) diet for 35 days and recovered with a normal protein (20%) diet for 70 days. Control rats received a normal protein diet for 105 days (CG 105 ). After cannulation surgery, mean arterial pressure, heart rate, respiratory frequency, tidal volume and minute ventilation were acquired using a digital recording system in freely moving rats. The role of angintensin II was evaluated by systemic antagonism of AT 1 receptors with losartan (20 mg kg −1 i.v.). The peripheral chemoreflex was elicited by increasing doses of KCN (20-160 μg kg min −1 , i.v.). At baseline, R-PR rats presented increased heart rate and minute ventilation (372 ± 34 beats min −1 and 1.274 ± 377 ml kg −1 min −1 ) compared with CG 105 animals (332 ± 22 beats min −1 and 856 ± 112 ml kg −1 min −1 ). Mean arterial pressure was not different between the groups. Pressor and bradycardic responses evoked by KCN (60 μg kg −1 ) were increased in R-PR (+45 ± 13 mmHg and −77 ± 47 beats min −1 ) compared with CG 105 rats (+25 ± 17 mmHg and −27 ± 28 beats min −1 ), but no difference was found in the tachypnoeic response. These differences were preserved after losartan. The data suggest that angiotensin II acting on AT 1 receptors may not be associated with the increased heart rate, increased minute

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

“…() and reported by us previously (Sá et al . ). Cardiovascular data analyses were carried out at baseline (before losartan) and 15 min after losartan injection.…”

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT₁ receptors

Sá

Haibara

Gomes

et al. 2016

Experimental Physiology

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The implication of protein malnutrition on cardiovascular control systems in rats

2015

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The malnutrition in early life is associated with metabolic changes and cardiovascular impairment in adulthood. Deficient protein intake-mediated hypertension has been observed in clinical and experimental studies. In rats, protein malnutrition also increases the blood pressure and enhances heart rate and sympathetic activity. In this review, we discuss the effects of post-weaning protein malnutrition on the resting mean arterial pressure and heart rate and their variabilities, cardiovascular reflexes sensitivity, cardiac autonomic balance, sympathetic and renin-angiotensin activities and neural plasticity during adult life. These insights reveal an interesting prospect on the autonomic modulation underlying the cardiovascular imbalance and provide relevant information on preventing cardiovascular diseases.

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Chemoreflex control of the cardiovascular system remains altered after recovery from low protein diet early in life

Cited by 2 publications

References 16 publications

Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT₁ receptors

Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT₁ receptors

The implication of protein malnutrition on cardiovascular control systems in rats

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Chemoreflex control of the cardiovascular system remains altered after recovery from low protein diet early in life

Cited by 2 publications

References 16 publications

Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT1 receptors

Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT1 receptors

The implication of protein malnutrition on cardiovascular control systems in rats

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Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT₁ receptors

Changes in cardiovascular responses to chemoreflex activation of rats recovered from protein restriction are not related to AT₁ receptors