Chemotherapeutic Resistance Genes of Breast Cancer Patients – An Overview

Abstract

Purpose: Cancer is the leading challenge to human health since the dawn of early Egyptian manuscripts, where they found tumour from fossils in the modernized twentieth century. Increasing rate of incidence and death from cancer in the past few years is thought provoking. Among all type of cancers, breast cancer is very common among women and diverse in character. Drug resistance is the challenging aspect for traditional chemotherapy. Methods: Data was collected from online platform without any time restriction. After screening and evaluation, 66 articles were considered for this study. This review is a summarized collection of information from published studies on human genes associated with drug resistance in breast cancer treatment. Results: Analysis of these findings highlights the importance of MAP kinase and ABC gene families in creating resistance barriers. Genes involved in cell cycle alteration, apoptosis, and hippo pathway were also linked with drug resistance particularly in breast cancer. Conclusion: The exact mechanism of chemotherapy resistance is still unresolved and unexplained the drug resistance seen in breast cancer patients were multifactorial. Drug induced up regulation or down regulation of genes contributes unusual protein expression and ultimately leads to resistance. The ultimate focus of this review is to identify the genes having pivotal role in chemotherapy resistance in breast cancer.

Breast cancer: miRNAs monitoring chemoresistance and systemic therapy

“…P-glyocoprotein (P-gp), glutathione Stransferase (GST-p), and P53 are only a few examples of MDR1encoded proteins that are involved in the chemoresistance cascade (44). In fact, Chen et al, 2022 suggested the synergistic effect of 7-Ogeranylquercetin and miR-451 on undoing MDR-1 and P-gpmediated chemoresistance in breast cancer MCF-7/ADR (Adriamycin) cells (45). The major chemoresistance mechanisms of cancer cells.…”