Breast cancer is the second most common cancer-related cause of death in women. BC is a multi-step process involving a range of cell types, and preventing it is still a difficult task all over the world. Agriculture is a massive industry that employs the majority of the world's population. Pesticides are a class of compounds with specific qualities that are used to remove pests. However, it occasionally exhibits severe biological activities in non-target creatures such as humans. About 504 patients and control samples were checked for pesticide levels and DNA Damage responsible for breast cancer, which is confirmed by checking the in vitro and in vivo experiments of DNA Damage. Statistical analysis was done using SPSS software. The results show positive involvement of breast cancer and pesticide risk. The relationship between pesticide and breast cancer due to DNA Damage is proved in this study. Further clinical implication of this study is to be explored to develop therapeutic approaches in treating the same.

Purpose: Cancer is the leading challenge to human health since the dawn of early Egyptian manuscripts, where they found tumour from fossils in the modernized twentieth century. Increasing rate of incidence and death from cancer in the past few years is thought provoking. Among all type of cancers, breast cancer is very common among women and diverse in character. Drug resistance is the challenging aspect for traditional chemotherapy. Methods: Data was collected from online platform without any time restriction. After screening and evaluation, 66 articles were considered for this study. This review is a summarized collection of information from published studies on human genes associated with drug resistance in breast cancer treatment. Results: Analysis of these findings highlights the importance of MAP kinase and ABC gene families in creating resistance barriers. Genes involved in cell cycle alteration, apoptosis, and hippo pathway were also linked with drug resistance particularly in breast cancer. Conclusion: The exact mechanism of chemotherapy resistance is still unresolved and unexplained the drug resistance seen in breast cancer patients were multifactorial. Drug induced up regulation or down regulation of genes contributes unusual protein expression and ultimately leads to resistance. The ultimate focus of this review is to identify the genes having pivotal role in chemotherapy resistance in breast cancer.