Chemotherapy as a primary treatment of Hodgkin's disease (204 new cases, 1 to 8 years of follow-up)

Jacquillat, C; Weil, M; Auclerc, G.; Desprez-Curely, J P; Chastang, Claude; Garçon, C; Chantalou, J.P.; Gemon-Auclerc, M.F.; Delobel, J; Dana, M; Tanzer, J; Teillet, F; Izrael, V.; Chelloul, N; C, Weisgerber; Heaulme, M. De; Boiron, M; Bernard, J

doi:10.1016/0014-2964(75)90041-9

European Journal of Cancer (1965)

1975

DOI: 10.1016/0014-2964(75)90041-9

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Chemotherapy as a primary treatment of Hodgkin's disease (204 new cases, 1 to 8 years of follow-up)

C Jacquillat

M Weil

G. Auclerc

et al.

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1977

1979

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Cited by 3 publications

References 13 publications

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Direct cytotoxicity test applied to patients in stage I and II of malignant skin melanoma

Kristensen¹,

Reimann²

1977

Cancer Immunol Immunother

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Using the direct eytotox~!city test described by Takasugi and Klein (1970), 59patients suffering from localized malignant skin melanoma (stages I and I I) were investigated for cell-mediated immunity. On an average, peripheral Iymphoeytes obtained preoperatively from 52patients showed a higher cytotoxicity against one of two established melanoma cell lines (RPMI 7931) as compared to lymphocytes from eontrol persons. No significant differences were found between lymphocytotoxicity of the patients and the controls against the control cell lines.In a prospective study, 17 patients were investigated. The results obtained so far suggest a correlation between a positive reaction postoperatively and recurrence of melanoma.It is clear that the eontrol group exerted a certain degree of "nonspecific" cytotoxiei,ty depending on the target cell used (established cell lines versus short-term cultures) and the lymphocyte~target cell ratio. Furthermore, there was a day-to-day variation in the nonspecific cytotoxieity exerted by lymphoeytes derived from the same control person.It is concluded that considerable refinements have to be made before the mierocytotoxic,ity assay becomes of clinical use in the evaluation of the postoperative status and course in melanoma patients.

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Direct cytotoxicity test applied to patients in stage I and II of malignant skin melanoma

Kristensen¹,

Reimann²

1977

Cancer Immunol Immunother

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Features and prognosis of chemotherapy-treated Hodgkin's disease with initial bone marrow involvement

Auclerc

Weil

et al. 1979

Cancer Chemother. Pharmacol.

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The features and prognosis of Hodgkin's disease with bone marrow involvement were studied in a series of 53 patients. This form of the disease is characterized by the high incidence of clinical and biological signs reflecting disease activity, common cytopenia (which is rare in other forms), an increased incidence of the lymphocyte depletion histologic type, and extensive lymphoid involvement, often with splenomegaly. In bone marrow biopsy specimens, Sternberg-Reed cells are found in 80% of cases and fibrosis is common, though it always disappears if remission is achieved. Chemotherapy, essentially with the MOPP combination, produced an 82% remission rate with 44% complete remission (CR). Hematologic toxicity was relatively severe in patients with marrow fibrosis. Recurrence occurred in 14 of the 39 remissions and was either localized and successfully treated by complementary radiotherapy, or diffuse and beyond any form of therapy. In nine cases, the first sign of recurrence was observed in the lymph node group initially most affected. Among the 18 patients treated by reinduction chemotherapy, four recurrences were observed. However, there was only one recurrence among the 12 patients who achieved CR and none among those who had received complementary radiotherapy. The long-term prognosis is similar to that of other visceral forms, and if CR is achieved the chance of maintaining the remission is 83% after the first year, with a follow-up exceeding 6 years.

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Staging and treatment of Hodgkin's disease

Amiel

Droz

1978

European Journal of Cancer (1965)

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Chemotherapy as a primary treatment of Hodgkin's disease (204 new cases, 1 to 8 years of follow-up)

Cited by 3 publications

References 13 publications

Direct cytotoxicity test applied to patients in stage I and II of malignant skin melanoma

Direct cytotoxicity test applied to patients in stage I and II of malignant skin melanoma

Features and prognosis of chemotherapy-treated Hodgkin's disease with initial bone marrow involvement

Staging and treatment of Hodgkin's disease

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