Chewable Oral Drug Products

Krämer, Johannes; Gajendran, Jayachandar; Guillot, Alexis; Barakat, Abdulwahab

doi:10.1002/9781118675748.ch2

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Whilst in the mouth, this dosage form provides a slow and steady release of the drug contained inside it [56]. Therefore, the drug delivery process depends on the patient-dosage form interaction [57,58]. When the masticatory process is absent, no relevant drug release occurs.…”

Section: Chewing Gumsmentioning

confidence: 99%

“…When the masticatory process is absent, no relevant drug release occurs. In fact, the controlled drug release action from the gum matrix is only active in the elastic state of the gum [57]. The masticatory activity of the patient determines the rate of transformation from the inactive, glassy, solid gum state to its active, rubbery, water-penetrating elastic mass responsible for regulating the drug release rate [57].…”

Section: Chewing Gumsmentioning

confidence: 99%

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Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

et al. 2022

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Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. Despite their advantages, current chewable formulations do not account for individualised dosing and palatability preferences. In light of this, three-dimensional (3D) printing, and in particular the semi-solid extrusion technology, has been suggested as a novel manufacturing method for producing customised chewable dosage forms. This advanced approach offers flexibility for selecting patient-specific doses, excipients, and organoleptic properties, which are critical for ensuring efficacy, safety and adherence to the treatment. This review provides an overview of the latest advancements in chewable dosage forms for human and veterinary use, highlighting the motivations behind their use and covering formulation considerations, as well as regulatory aspects.

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Section: Chewing Gumsmentioning

confidence: 99%

Section: Chewing Gumsmentioning

confidence: 99%

Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

et al. 2022

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“…Обзоры литературы для экструзионного формования жевательная резинка выдавливается в выходной патрубок (3) фильеры (2) под давлением. Скорость смешивания ингредиентов и последующего охлаждения взаимно влияют друг на друга и на скорость экструзии РЖЛ, поэтому представленные процессы необходимо контролировать надлежащим образом [13].…”

Section: разработка составов резинок жевательных лекарственныхunclassified

Special Aspects of the Technology of Medicated Chewing Gum Production

Blynskaya

Tishkov

Alekseev

et al. 2020

Rossijskij bioterapevtičeskij žurnal

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Chewing gum medicines are solid dosage forms intended for chewing for a certain period of time without subsequent ingestion to provide local and systemic effects. This article describes the basic technologies for producing chewing gum medicinal products, analyzes and compares the technological aspects of production. In addition, the advantages and disadvantages of the various technologies used, the features of the use in pharmaceutical technology, as well as additional technological methods for creating modifications of the release of drugs from chewing gum medicinal gums are given. It is concluded that the application of various technologies for the production of chewing gums and the methods for improving individual stages of the process are promising.

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“…When chewing these tablets, the active compounds are first released in the mouth, and the rest of the compounds are excreted in the stomach and intestines; this can be adapted in creating a localized effect in the oral cavity. In addition, microcapsules can prolong active substance release (depending on the excipients) and this can be adapted for systemic effect [37][38][39][40][41]. The creation of gel-based tablets with incorporated microcapsules, such as nutmeg or other essential oils, as an active compound is a new method to develop pharmaceutical forms which can be adapted for the elderly, children, or people who have swallowing disorders [42].…”

Section: Introductionmentioning

confidence: 99%

Development of Innovative Chewable Gel Tablets Containing Nutmeg Essential Oil Microcapsules and Their Physical Properties Evaluation

2021

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Chewable gel tablets are a dosed pharmaceutical form, which can have an active substance, pharmacological effect, or value of nutrition. The texture of these tablets is soft, springy, flexible, and elastic—this is influenced by the chosen ingredients. The aim of this study was to prepare chewable gel tablets with nutmeg essential oil-loaded microcapsules and determine the volatile compounds released from this pharmaceutical form. Gel tablets were prepared by using gelatin as basis, nutmeg essential oil as active compound, and natural ingredients: thyme-sugar syrup, thyme extract, and citric acid as taste and color additives. Texture properties were measured by a texture analyzer. The release of volatile compounds from nutmeg essential oil and gel tablets were analyzed by headspace-gas chromatography with mass spectroscopy in control and artificial saliva conditions in vitro. Nutmeg essential oil microcapsules had influence on the gel tablet’s physical properties (p < 0.05, by comparing tablets without glycerol and relative sample with glycerol); glycerol protects the tablets from the formation of sugar crystals on top and keeps good physical parameters (p < 0.05). A total of 12 volatile compounds were identified in nutmeg essential oil, and the six compounds with the highest amounts were selected as controls. Gel tablets prolong the release time of volatile compounds and reduce the amount of the compounds compared to the microcapsules (p < 0.05).

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Chewable Oral Drug Products

Cited by 5 publications

References 25 publications

Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

Special Aspects of the Technology of Medicated Chewing Gum Production

Development of Innovative Chewable Gel Tablets Containing Nutmeg Essential Oil Microcapsules and Their Physical Properties Evaluation

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