Chicken and turkey meat: Consumer exposure to multidrug-resistant Enterobacteriaceae including mcr-carriers, uropathogenic E. coli and high-risk lineages such as ST131

Díaz-Jiménez, Dafne; García-Meniño, Isidro; Fernández, Javier; García, Vanesa; Mora, Azucena

doi:10.1016/j.ijfoodmicro.2020.108750

Cited by 44 publications

(57 citation statements)

References 62 publications

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“…Recently, it has been obtained from sick and healthy dogs in Vila Real, a city in northern Portugal very close to Galicia, carrying bla CTX-M-15 and bla SHV-28 [ 50 ]. This clone (including CTX-M-15- SHV-28-producing isolates) was also detected in 27% of the poultry meat samples analyzed by Díaz-Jiménez et al in Galicia [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is of note that in a recent study performed in our region (Galicia) on chicken and turkey meat, we recovered five (5%) ESBL-producing Escherichia clade I ST770 (CH116-552) from different samples, all of them positive for the ExPEC status [ 34 ]. Furthermore, three of these isolates were O1:H45.…”

Section: Discussionmentioning

confidence: 99%

“…As stated above, dogs may acquire antimicrobial resistant Enterobacteriaceae via various routes, including raw feeding with chicken meat or carcasses, which is quite common in rural areas. Poultry products can act as a reservoir for human extraintestinal Enterobacteriaceae pathogens [ 34 , 35 , 36 ], so we also hypothesize that such products could be playing a role in their transmission between animals, particularly in rural environments. Importantly, MDR E. coli of human clinical origin and characterized as A-ST93 (CH11-neg), B1-ST453 (CH6-31), and F-ST1485 (CH231-58) were also recently reported in the same health area (Galicia) [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

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High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain

et al. 2020

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The aim of this work was to assess the prevalence of extended spectrum-β-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae in fecal samples recovered from rural and urban healthy dogs in Northwest Spain (Galicia) to identify potential high-risk clones and to molecularly characterize positive isolates regarding the genes coding for ESBL/pAmpC resistance and virulence. Thirty-five (19.6%) out of 179 dogs were positive for cephalosporin-resistant Enterobacteriaceae, including Escherichiacoli and Klebsiella pneumoniae (39 and three isolates, respectively). All the isolates were multidrug resistant, with high rates of resistance to different drugs, including ciprofloxacin (71.4%). A wide diversity of ESBL/pAmpC enzymes, as well as E. coli phylogroups (A, B1, C, D, E, F and clade I) were found. The eight isolates (20.5%) found to conform to the ExPEC status, belonged to clones O1:H45-clade I-ST770 (CH11-552), O18:H11-A-ST93-CC168 (CH11-neg), O23:H16-B1-ST453-CC86 (CH6-31), and O83:H42-F-ST1485-CC648 (CH231-58), with the latter also complying the uropathogenic (UPEC) status. The three K. pneumoniae recovered produced CTX-M-15 and belonged to the ST307, a clone previously reported in human clinical isolates. Our study highlights the potential role of both rural and urban dogs as a reservoir of high-risk Enterobacteriaceae clones, such as the CC648 of E. coli and antimicrobial resistance traits. Within a One-Health approach, their surveillance should be a priority in the fight against antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain

et al. 2020

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“…Moreover, most E. coli and Salmonella spp. isolates were found to be MDR, which makes it difficult to treat the infected turkeys [37][38][39][40][41][42]. Antibiograms can guide the choice of therapies for colibacillosis and salmonellosis in turkeys.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Characterization of Multidrug-Resistant Escherichia coli and Salmonella spp. from Healthy and Diseased Turkeys

et al. 2020

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Diseases caused by Escherichia coli (E. coli) and Salmonella spp. can negatively impact turkey farming. The aim of this study was to isolate and characterize multidrug-resistant (MDR) E. coli and Salmonella spp. in healthy and diseased turkeys. A total of 30 fecal samples from healthy turkeys and 25 intestinal samples from diseased turkeys that died of enteritis were collected. Bacterial isolation and identification were based on biochemical properties and polymerase chain reaction (PCR). Antibiogram profiles were determined by disk diffusion. The tetracycline-resistance gene tetA was detected by PCR. All samples were positive for E. coli. Only 11 samples (11/30; 36.67%) were positive for Salmonella spp. from healthy turkeys, whereas 16 (16/25; 64%) samples were positive for Salmonella spp. from diseased turkeys. E. coli isolated from diseased turkeys showed higher resistance to levofloxacin, gentamicin, chloramphenicol, ciprofloxacin, streptomycin, and tetracycline. Salmonella spp. isolated from healthy turkeys exhibited higher resistance to gentamicin, chloramphenicol, ciprofloxacin, streptomycin, imipenem, and meropenem. All E. coli and Salmonella spp. from both healthy and diseased turkeys were resistant to erythromycin. Salmonella spp. from both healthy and diseased turkeys were resistant to tetracycline. Multidrug resistance was observed in both E. coli and Salmonella spp. from diseased turkeys. Finally, the tetA gene was detected in 93.1% of the E. coli isolates and in 92.59% of the Salmonella spp. isolates. To the best of our knowledge, this is the first study to isolate and characterize tetA-gene-containing MDR E. coli and Salmonella spp. from healthy and diseased turkeys in Bangladesh. Both microorganisms are of zoonotic significance and represent a significant public health challenge.

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“…6 Several studies have highlighted the presence of MDROs in meat and poultry found in grocery stores. 7 , 8 Limiting the use of antibiotics in this realm would go a long way to reducing the emergence of MDROs. Dr. Sameer Patel and co-authors review the current state of antibiotic use in animal food production and highlight strategies to expand antimicrobial stewardship into this arena.…”

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Combating Antimicrobial Resistance: Going Beyond New Antibiotics

Jhaveri

2020

Clinical Therapeutics

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At the outset of 2020 and prior to coronavirus disease 2019 usurping our attention, the discussion among infectious disease practitioners was focused on the alarming increases in multidrug (antimicrobial)-resistant organisms (MDROs). 1 Antimicrobial resistance had been identified by the Obama administration as a global threat that warranted issuance of a national action plan which outlined needed steps to confront this threat. 2 Although most have looked to new antibiotics as the primary means to combating resistance, this strategy is flawed for many reasons. Given that most antibiotics were originally derived from fungi and other bacteria, bacterial resistance to antibiotics is an evolutionary strategy that has existed since the beginning of time. Market forces do not favor the development of antibiotics, which are used for short periods of time and are often subjected to restricted use to prevent emergent resistance. 3 This means that the profit potential is lower for antibiotics compared with other agents. The Infectious Diseases Society of America has long drawn attention to the dearth of antibiotics in development and has advocated for multiple measures to increase the incentives for antibiotic production. 3e5 For these reasons, efforts to tackle antimicrobial resistance need to go beyond just new antibiotics. Thus, this month's Specialty Update focuses on "Combating Antimicrobial Resistance: Going Beyond New Antibiotics." When considering the major drivers of antimicrobial resistance, most people tend to focus on the medical uses of antibiotics. The sad truth is that the volumes of medical use of antibiotics are dwarfed by the enormous quantities of antibiotics used in animal food production. 6 Several studies have highlighted the presence of MDROs in meat and poultry found in grocery stores. 7,8 Limiting the use of antibiotics in this realm would go a long way to reducing the emergence of MDROs. Dr. Sameer Patel and co-authors review the current state of antibiotic use in animal food production and highlight strategies to expand antimicrobial stewardship into this arena. 9 They specifically highlight the concept of the "One Health" model and write:

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Chicken and turkey meat: Consumer exposure to multidrug-resistant Enterobacteriaceae including mcr-carriers, uropathogenic E. coli and high-risk lineages such as ST131

Cited by 44 publications

References 62 publications

High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain

High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain

Isolation and Characterization of Multidrug-Resistant Escherichia coli and Salmonella spp. from Healthy and Diseased Turkeys

Combating Antimicrobial Resistance: Going Beyond New Antibiotics

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