Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model

Yu, Wen-Ying; Chuang, Tung‐Han; Guichard, Cécile; El-Garch, Hanane; Tierny, Dominique; Laio, Albert Taiching; Lin, C. H.; Chiou, Kuo-Hao; Tsai, Cheng-Chia; Liu, Chen-Hsuan; Li, Wen-Chiuan; Fischer, Laurent; Chu, Ruiai

doi:10.1016/j.vaccine.2011.02.031

Cited by 20 publications

(7 citation statements)

References 49 publications

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“…Pai et al evaluated fused DC/TVT hybrids as a vaccine against TVT and reported substantial inhibition of tumour progression and accelerated regression in the vaccinated group. Successful protection against TVT has also been reported with a Chicken HSP70 DNA vaccine …”

Section: Treatmentmentioning

confidence: 94%

Canine transmissible venereal tumour: a review

Ganguly

Das²,

Das

2013

Vet Comparative Oncology

136

164

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Canine transmissible venereal tumour (CTVT) is a contagious venereal tumour of dogs, commonly observed in dogs that are in close contact with one another, or in stray and wild dogs that exhibit unrestrained sexual activity. CTVT represents a unique, naturally transmissible, contagious tumour, where the mutated tumour cell itself is the causative agent and perpetuates as a parasitic allograft in the host. Clinical history, signalment and cytological features are often obvious for establishing a diagnosis though biopsy and histological examination may be needed in atypical cases. Most cases are curable with three intravenous injections of vincristine sulphate at weekly intervals. The role of stray and wild dogs makes the disease difficult to control and necessitates sustained animal birth control in stray dogs along with prompt therapy of the affected dogs. This review captures the manifold developments in different areas embracing this fascinating tumour, including its biology, diagnosis and therapeutic alternatives.

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Section: Treatmentmentioning

confidence: 94%

Canine transmissible venereal tumour: a review

Ganguly

Das²,

Das

2013

Vet Comparative Oncology

136

164

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“…The effect of the immune response was amplified when HER2 immunization was combined to a temporary regulatory T-cell depletion treatment, but only if the microscopic cancer was small enough (not palpable, Rolla et al, 2010). Other recent results describe the efficacy of the xenogenic chicken HSP70 antigen in a prime boost strategy for a canine transmissible venereal tumor (Yu et al, 2011), metalloproteinase MMP11 antigen in a colon cancer mouse model (Peruzzi et al, 2009), cancer testis antigen PASD1 fused to the tetanus toxin DOM epitope in a multiple myeloma mouse model ( Joseph-Pietras et al, 2010), a human surviving epitope against the B16 melanoma mouse model after intradermal delivery (Lladser et al, 2010), or secreted telomerase combined with an adenovirus boost in a dog lymphoma model (Peruzzi et al, 2010).…”

Section: Cancermentioning

confidence: 99%

Genetic Immunization with Plasmid DNA Mediated by Electrotransfer

2011

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The concept of DNA immunization was first advanced in the early 1990s, but was not developed because of an initial lack of efficiency. Recent technical advances in plasmid design and gene delivery techniques have allowed renewed interest in the idea. Particularly, a better understanding of genetic immunization has led to construction of optimized plasmids and the use of efficient molecular adjuvants. The field also took great advantage of new delivery techniques such as electrotransfer. This is a simple physical technique consisting of injecting plasmid DNA into a target tissue and applying an electric field, allowing up to a thousandfold more expression of the transgene than naked DNA. DNA immunization mediated by electrotransfer is now effective in a variety of preclinical models against infectious or acquired diseases such as cancer or autoimmune diseases, and is making its way through the clinics in several ongoing phase I human clinical trials. This review will briefly describe genetic immunization mediated by electrotransfer and the main fields of application.

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Section: Dna‐egtmentioning

confidence: 99%

“…The two different delivery routes for DNA vaccines have been recently compared in laboratory beagles inoculated with transmissible venereal tumour. A direct comparison in this canine model has been recently provided by Yu et al 22 using a xenogeneic chicken HSP70 DNA vaccine. The needle-free transdermal route was less potent both in evoking an immune response and a clinical response than the electroporation-based DNA delivery method.…”

Section: Dna-egtmentioning

confidence: 99%

Electro‐gene‐transfer as a new tool for cancer immunotherapy in animals

Impellizeri

Ciliberto

Aurisicchio³

2012

Vet Comparative Oncology

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The concept of vaccines based on the direct inoculation of plasmid DNA gained initial proof-of-concept in small rodent species. Further development was hampered by the difficulty to confirm immunogenicity and efficacy in large animal species and, most importantly, in human clinical trials. These negative findings led to the search of complementary technologies which, in combination with intradermal or intramuscular plasmid DNA injection would result in more robust delivery, decreased interindividual variability, clear evidence of clinical efficacy and which would eventually lead to market approval of new vaccine products. The use of high-pressure, needleless devices as an enhancing tool for plasmid DNA delivery led to recent approval by USDA of Oncept™, a therapeutic cancer vaccine directed against tyrosinase for the therapy of melanoma in dogs. An alternative approach to improve plasmid DNA delivery is electro-gene-transfer (EGT). In this article, we briefly review the principles of DNA-EGT and the evidences for efficacy of a telomerase reverse transcriptase vaccine in a dog clinical trial, and provide perspectives for the use of this technology for broader applications in pet animals.

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Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model

Cited by 20 publications

References 49 publications

Canine transmissible venereal tumour: a review

Canine transmissible venereal tumour: a review

Genetic Immunization with Plasmid DNA Mediated by Electrotransfer

Electro‐gene‐transfer as a new tool for cancer immunotherapy in animals

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