Childhood Obesity

Chief, Michael Freemark Md Professor

doi:10.1002/9781444316728.ch20

Brook's Clinical Pediatric Endocrinology 2009

DOI: 10.1002/9781444316728.ch20

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Childhood Obesity

Michael Freemark Md Professor Chief

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Cited by 3 publications

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The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population

Lubis

Fattah²,

Batubara

2022

Egypt J Med Hum Genet

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Background Several studies have reported that fat mass and obesity-associated gene (FTO), especially the rs9939609 polymorphism, are associated with obesity and high leptin levels. The free leptin index (FLI) is known to be accurate in determining the function of leptin. The aim of this study was to determine the association between the rs9939609 variant in the FTO gene and FLI and the risk of obesity among children living in Medan, Indonesia. Methods This case–control study included 212 children aged 6–12 years who were genotyped for variants of the rs9939609 FTO gene. The case group consisted of children with obesity who were < 6 years old, and the control group had a normal body mass index and came from the Bataknese or Chinese ethnicities. Anthropometric measurements were performed. Serum leptin and soluble leptin receptor (sOB-R) levels were measured. Odds ratio and 95% confidence intervals were calculated to determine the risk of having obesity associated with the risk allele. Results In this study, there was no significant association between leptin, soluble leptin receptor, or free leptin index and the rs9939609 FTO gene; however, the risk allele (A) of FTO rs9939609 had a significant association with obesity in Chinese ethnicity subjects (p < 0.05). The AA/AT genotype had an increased risk of FLI 5.889 times compared to the TT genotype. Multivariate analysis showed that the rs9939609 polymorphism in the FTO gene played a role in obesity through the FLI. Conclusion It was concluded that the rs9939609 polymorphism played a significant role in obesity through FLI. Further studies are still needed.

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The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population

Lubis

Fattah²,

Batubara

2022

Egypt J Med Hum Genet

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Prediction of the Risk of Developing Type 2 Diabetes Mellitus Using Body Mass Index in Adolescents

Shanthi¹,

Manjunatha²,

Bharamakkanavar³

2019

jemds

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BACKGROUND Overweight and obesity are recognized as an escalating epidemic affecting both developed and developing countries. Body Mass Index (BMI) is promulgated by WHO as the most useful epidemiological measure of obesity. Obesity is one of the most important modifiable risk factors in pathogenesis of type 2 diabetes mellitus. Studies have indicated that Indians are highly susceptible to diabetes even with modest overweight, central obesity and physical inactivity. The objectives of this study were-1. to determine the relation between body mass index and fasting blood sugar 2. to determine the factors influencing childhood obesity and type 2 diabetes. MATERIALS AND METHODS After obtaining consent from the school authorities and parents, details of the children were collected. Weight, height and fasting blood sugar of the children were measured. Body Mass Index was calculated. The data was analysed statistically. RESULTS The prevalence of overweight was 14.8% and obesity was 9.0%. There is a positive correlation between Body Mass Index and Fasting Blood Sugar with a r value of 0.826 and a p value of 0.0001. Socioeconomic status and TV watching time have a positive influence on Body Mass Index. Family history of type 2 Diabetes Mellitus has a positive correlation with Body Mass Index and Fasting Blood Sugar.

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Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

TAŞTANOĞLU¹,

Çelik²

2021

Cumhuriyet Medical Journal

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There is a lot of study in adults investigating the Triglyceride-Glucose (Ty-G) index. However, a limited study has been searched in the pediatric age group. Moreover, to the best of our knowledge, there is no study on Turkish children. The aim of this study, to investigate the usability of the triglyceride-glucose index as an indicator of insulin resistance in obese adolescents and to calculate the cut-off values.Method: Six hundred twenty-three pubertal obese adolescents (266 boys, and 357 girls) were retrospectively evaluated. Ty-G index and HOMA-IR levels were calculated. ROC analysis was used for the estimations of the Ty-G index cutoff value.Results: There was positive correlation between HOMA-IR and Ty-G index in boys (r=0.255, p<0.001), in girls (r=0.402, p<0.001), and all study groups (r=0.323, p<0.001). Ty-G index cutoff value for insülin resistance in pubertal obese adolescents was calculated as 8.42 with 70.1 % sensitivity and 59.3 % specificity for all study groups; 8,38 with 71.1 % sensitivity, and 48.3 % specificity for boys; 8,27 with 80% sensitivity, and 52.9% specificity for girls.Conclusions: Ty-G index may be a reliable indicator for insülin resistance in pubertal obese adolescents. More attention should be given fort his marker with prospective studies.

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Childhood Obesity

Cited by 3 publications

References 223 publications

The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population

The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population

Prediction of the Risk of Developing Type 2 Diabetes Mellitus Using Body Mass Index in Adolescents

Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

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