Children of School Age: The Influence of Antiepileptic Drugs on Behavior and Intellect

Trimble, Michael; Cull, Christine

doi:10.1111/j.1528-1157.1988.tb05805.x

Cited by 68 publications

(19 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A prospective study with repeated psychological evaluations is pertinent for such an analysis (Bourgeois et al, 1983). Drowsiness and concentration problems that influence cognitive abilities may be AED side effects, especially with polytherapy (Trimble and Cull, 1988). These were common complaints in our patients and had made 4 of them prefer seizures to chronic medication.…”

Section: Discussionmentioning

confidence: 95%

Social Adjustment in Young Adults with Absence Epilepsies

Olssøn

Campenhausen

1993

Epilepsia

View full text Add to dashboard Cite

A long-term follow-up of 58 young adults, aged 18-27 years, with persisting absence epilepsies since childhood or early adolescence, was performed to assess psychosocial outcome and the patients' own concept of their epilepsy. They were well adjusted in the areas of family status and employment, but had more unqualified jobs as compared with a reference group. They were also inclined to lead very regular lives in a way that led to social isolation. At least one of the following factors was considered by 74% of the group to have been affected by their epilepsy: schooling, occupation, routines of daily life, relations with friends, leisure time activities, and housing, this was independent of whether or not they had achieved seizure control. In treating absence epilepsies, it is important that one considers psychosocial aspects, even if a medically satisfying result with seizure control is obtained.

show abstract

Section: Discussionmentioning

confidence: 95%

Social Adjustment in Young Adults with Absence Epilepsies

Olssøn

Campenhausen

1993

Epilepsia

View full text Add to dashboard Cite

show abstract

“…After carbamazepine, phenobarbital was the most frequently prescribed AED, which may have contributed to the decrease in school performance observed in the children taking it, given its proven capacity to cause sedation and behavioral disorders [31] . Indexes of grade repetition and the teachers' opinion clearly highlight that children with epilepsy experience greater scholastic diffi culties than those unaffected.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Survey of Epilepsy in the Primary School Population in Buenos Aires

Somoza¹,

Forlenza²,

Brussino³

et al. 2005

Neuroepidemiology

View full text Add to dashboard Cite

Background: Most studies carried out in Latin America have shown greater rates of epilepsy and generalized seizures than those observed in developed countries, in spite of lower numbers of patients receiving treatment. To date, studies in Argentina have been insufficient to establish true prevalence. Objective: To determine the prevalence of epilepsy in primary school children in Buenos Aires, together with rates of different seizure types, treatments prescribed, diagnoses made and number of inadequate therapies administered, as well as the relationship between epilepsy and learning difficulties. Design and Method: A cross-sectional study was carried out on 10% of the entire primary school population of Buenos Aires through randomized, systematic, representative and conglomerate sampling of public and private school students. A total of 26,270 responses were received (83.1% of the population) to a specially designed questionnaire, with 96.4% sensitivity and 41.5% specificity, respectively. Interviews were conducted in all probable epilepsy cases as well as in a random sample of probable negative ones. Results: Eighty-four children with epilepsy were detected (lifetime prevalence 3.2‰; active prevalence 2.6‰), in whom generalized seizures predominated (57.1%). Ninety-three percent of cases diagnosed were currently under, or had previously received antiepileptic drug (AED) therapy. Almost 1% of the primary school population studied had a prior diagnosis and/or received AED for dysrhythmia or epilepsy. The percentage of grade repeaters in the general population and in children with epilepsy was 8.4 and 26.2%, respectively. Conclusions: (1) The prevalence of epilepsy in primary school children in Buenos Aires is similar to that reported for developed countries; (2) a slight prevalence for generalized seizures was observed; (3) 93% of cases received AEDs; (4) misdiagnoses and unnecessary treatments exceeded correct diagnoses and adequate therapy, and (5) disease presence and/or treatment were associated with poorer school performance.

show abstract

“…As crianças com problemas de comportamento e as com retardo mental parecem ser mais suscetíveis 52 . Este efeito é maior com politerapia do que com monoterapia.…”

Section: A Definição Do Momento Da Cirurgia (Time)unclassified

Tratamento cirúrgico das epilepsias na criança

Costa¹

2002

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: to review the literature on surgical treatment of epilepsy in children.Sources: this review article is based on critical analysis of literature concerning epilepsy surgery for children.Summary of the findings: in children and adolescents, developmental abnormalities and low-grade tumors predominate as causes and types of epilepsies. Extratemporal resections and hemispherectomies are common in pediatric series, and hippocampal sclerosis is rare. Seizure-free outcome is significantly less frequent after extratemporal or multilobar resection than after temporal resection in children than in adults, but the results are gratifying in both groups. Also, a global outcome, including parental satisfaction, developmental and social outcome, as well as activities of daily living (ADL), schooling, and behavioral changes should be considered. Pediatric epilepsy surgical series show that 60-100% of the patients have a good seizure outcome. Roughly 30 to 40% of patients improve some aspects of their behavior such as attention, aggressiveness, and hyperactivity and 16% of those start to attend school after surgery. Parents noted improvement of their social life in about 2/3 of children.Conclusions: surgery for epilepsy has now become a realistic therapeutic option for selected children and the field is likely to increase in the near future. Surgical therapy should not be considered unless there is a reasonably good chance of improving the patient's quality of life. ResumoObjetivo: realizar revisão bibliográfica sobre o tratamento cirúrgico das epilepsias na criança.Fontes dos dados: artigo de revisão baseado em análise crítica da literatura atual sobre cirurgia da epilepsia em crianças. Síntese dos dados:em crianças e adolescentes, as anormalidades de desenvolvimento e os tumores de baixo grau de malignidade predominam entre as etiologias possíveis. A esclerose hipocampal é rara nas séries pediátricas, em que predominam as resecções extratemporais e hemisferectomias. O controle total das crises é mais freqüente nas resecções temporais, e menos freqüente nas resecções extratemporais ou multilobares. Entretanto, os resultados são gratificantes em ambos os grupos. É importante também considerar o seguimento global do paciente, incluindo a satisfação dos pais, a melhora no desenvolvimento neuropsicomotor e social, as atividades da vida diária, as modificações comportamentais e no rendimento escolar. Nas séries pediátricas, 60-100% dos pacientes têm uma boa evolução pós-operatória. Aproximadamente 30 a 40% dos pacientes melhoram em algum aspecto do seu comportamento, tais como atenção, agressividade e hiperatividade, e 16% destes pacientes iniciam a atividade escolar após a cirurgia. Os pais notaram a melhora no comportamento social em aproximadamente 2/3 das crianças.Conclusões: a cirurgia da epilepsia em crianças tornou-se uma opção realística para casos selecionados, e tende a se expandir num futuro próximo. A terapêutica cirúrgica só deve ser indicada se houver uma boa oportunidade de melhorar a qualidade de ...

show abstract

Children of School Age: The Influence of Antiepileptic Drugs on Behavior and Intellect

Cited by 68 publications

References 16 publications

Social Adjustment in Young Adults with Absence Epilepsies

Social Adjustment in Young Adults with Absence Epilepsies

Epidemiological Survey of Epilepsy in the Primary School Population in Buenos Aires

Tratamento cirúrgico das epilepsias na criança

Contact Info

Product

Resources

About