Children's exposure to environmental lead: A review of potential sources, blood levels, and methods used to reduce exposure

Swaringen, Benjamin F.; Gawlik, Emory; Kamenov, George D.; McTigue, Nancy E.; Cornwell, David A.

doi:10.1016/j.envres.2021.112025

Cited by 44 publications

(19 citation statements)

References 177 publications

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“…Also shown in the theoretical framework (Figure 2), environ- Michigan. 44 This crisis elevated the awareness and issue of lead poisoning and ignited a public outcry worldwide. 45,46 Studies suggest that these events caused an increase in the public interest.…”

Section: Discussionmentioning

confidence: 99%

“…For example, for several decades, the negative effects of lead exposure on children's health (such as cognition, school performance and mortality) have been well established 43 . Despite the knowledge of the negative impacts of lead poisoning, the United States has continued to see extensive human exposure to lead poisoning, threatening the health and livelihood of children 44 . While the effects of lead on human health were well established, interest in children's environmental health issues increased during the 2014–2015 crisis of lead‐contaminated drinking water in Flint Michigan 44 .…”

Section: Discussionmentioning

confidence: 99%

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Environmental health perceptions of urban youth from low‐income communities: A qualitative photovoice study and framework

Sprague,

Zonnevylle,

Jackson Hall

et al. 2023

Health Expectations

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BackgroundChildren are amongst the most susceptible groups to environmental exposures, for both immediate and life‐course health outcomes. Despite their increased susceptibility, children's knowledge, experiences and voices are understudied. A deeper understanding of children's environmental health perceptions has the potential to better inform policy, develop targeted interventions and improve public health outcomes.MethodsIn this study, our community–academic partnership used the Photovoice research method to examine how urban children from low‐income communities perceive environmental influences on their health. Twenty children, ages 10–12, took photographs and participated in focus group interviews regarding their perspectives on how the environment influences their health.ResultsQualitative analyses revealed five major thematic categories: environmental exposures, environmental health sentiments, environmental health outcomes, interest in environmental health and environmental health solutions. We used the findings to develop an environmental health perspective theoretical framework that can inform future work designed to promote the environmental health and well‐being of children from low‐income communities in urban communities.ConclusionPhotovoice enabled children from low‐income communities to capture and communicate their environmental health perceptions. These findings have the potential to inform and identify potential targets and opportunities for environmental health interventions and promotion in their communities.Patient or Public ContributionPartnerships with community‐based organizations were central to the present study. By design, these community‐based partners were involved in the conduct and procedures of the study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Environmental health perceptions of urban youth from low‐income communities: A qualitative photovoice study and framework

Sprague,

Zonnevylle,

Jackson Hall

et al. 2023

Health Expectations

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“…The heavy metal lead (Pb) has adversely affected human health for thousands of years. 1 Although people have gradually discovered its toxic impacts, Pb remains dangerous because of the lack of conspicuous signs of Pb poisoning, especially with low exposure. 2 Substantial Pb exposure can cause severe health problems such as cardiovascular and renal dysfunctions, and irreversible neuronal damage is observed, but no symptoms specific to Pb poisoning can be used to confirm a diagnosis; sampled body fluid must be discovered directly to contain Pb.…”

Section: Lead As An Unseen Hazardmentioning

confidence: 99%

Portable sensing devices for smart healthcare and prevention of lead poisoning

Lai

Huang

Liang

et al. 2023

Journal of the Chinese Medical Association

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Lead (Pb) poisoning can damage human bodies silently, without specific symptoms or conspicuous warning signs. To provide safe and user-friendly tools for detecting heavy metals at low concentrations, scientists have developed and optimized versatile biosensors. To practically employ the developed biosensors specific for Pb (eg, the optimized Met-lead 1.44 M1), smartphone applications designed for user convenience and are easily operable for the on-site detection of Pb in environmental water, drinking water, food, and blood/urine are urgently needed. To establish a monitoring system for home health maintenance, a portable device and useful apps installed on a smartphone can be integrated, and the data acquired can be sent to and stored in the cloud for further analysis and evidence preservation. With the high transmissions speeds for 4G and 4G wireless Internet, such a system can be applied for health protection; water-quality data can be provided by anyone and publicly shared for display on smartphone interfaces, alerting individuals of heavy metal contamination. In this review, we describe recent developments in heavy metal-sensing devices, including home health maintenance systems, which have been successfully and practically applied to prevent heavy metal Pb poisoning.

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“…There is a consensus that Pb exposure damages children’s neurological and cognitive development, and can even lead to those children behaving antisocially and delinquently [ 6 , 7 ]. In recent years, there has been Pb contamination in drinking water in many U.S. cities, which has aroused public attention to the threat of Pb contamination to human health [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Lead Disrupts Mitochondrial Morphology and Function through Induction of ER Stress in Model of Neurotoxicity

Xue

Wang

et al. 2022

IJMS

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Lead exposure may weaken the ability of learning and memory in the nervous system through mitochondrial paramorphia and dysfunction. However, the underlying mechanism has not been fully elucidated. In our works, with SD rats, primary culture of hippocampal neuron and PC12 cell line model were built up and behavioral tests were performed to determine the learning and memory insults; Western blot, immunological staining, and electron microscope were then conducted to determine endoplasmic reticulum stress and mitochondrial paramorphia and dysfunction. Co-immunoprecipitation were performed to investigate potential protein–protein interaction. The results show that lead exposure may cripple rats’ learning and memory capability by inducing endoplasmic reticulum stress and mitochondrial paramorphia and dysfunction. Furthermore, we clarify that enhanced MFN2 ubiquitination degradation mediated by PINK1 may account for mitochondrial paramorphia and endoplasmic reticulum stress. Our work may provide important clues for research on the mechanism of how Pb exposure leads to nervous system damage.

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Children's exposure to environmental lead: A review of potential sources, blood levels, and methods used to reduce exposure

Cited by 44 publications

References 177 publications

Environmental health perceptions of urban youth from low‐income communities: A qualitative photovoice study and framework

Environmental health perceptions of urban youth from low‐income communities: A qualitative photovoice study and framework

Portable sensing devices for smart healthcare and prevention of lead poisoning

Lead Disrupts Mitochondrial Morphology and Function through Induction of ER Stress in Model of Neurotoxicity

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