Chimeric maternal cells in offspring do not respond to renal injury, inflammatory or repair signals

López-Guisa, Jesús M.; Howsmon, Rebecca; Munro, Andrew W.; Blair, Kendall M.; Fisher, Edward A.; Hermes, H.; Zager, Richard A.; Stevens, Anne M.

doi:10.4161/chim.2.2.16446

Cited by 3 publications

(1 citation statement)

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“…Not all studies support this hypothesis. In a mouse model of renal inflammation, maternal microchimerism was not found to differ between acute injury, chronic injury and control animals [65]. …”

Section: Autoimmune Diseasementioning

confidence: 99%

Maternal–fetal cellular trafficking

Jeanty

Derderian

MacKenzie

2014

Current Opinion in Pediatrics

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Purpose of review Maternal-fetal cellular trafficking (MFCT) is the bidirectional passage of cells between mother and fetus during pregnancy. This results in the presence of fetal cells in the maternal circulation, known as fetal microchimerism, and maternal cells in the fetal circulation, known as maternal microchimerism. The biologic role of this bidirectional passage of cells during pregnancy is not known, although it has been implicated in development of the fetal immune system, tolerance mechanisms during pregnancy, tissue repair in autoimmune disease and cancer, and immune surveillance. Recent findings Clinical utility of MFCT has been identified in prenatal testing for aneuploidies and prediction of pregnancy complications. Additionally, this transplacental passage of cells has been implicated in the delicate balance between immunologic priming and tolerance which can influence the occurrence of autoimmune disease and transplantation outcomes. Ongoing studies are evaluating the utility of microchimerism in predicting the risk of graft rejection in transplantation. Summary In this review, we will discuss the clinical implications of MFCT in pregnancy, fetal surgery, autoimmune disease, transplantation, and cancer.

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Section: Autoimmune Diseasementioning

confidence: 99%